Novel surface-modified bioresorbable zinc-based stent materials

新型表面改性生物可吸收锌基支架材料

• 批准号: 10282711
• 负责人: Yadong Wang
• 金额: $ 39.54万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10282711
• 关键词: Abeta synthesis; Achievement; Address; Adverse effects; Affect; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease patient; Amygdaloid structure; Amyloid beta-42; Amyloid beta-Protein; Animal Model; Astrocytes; Binding; Biological; Biological Assay; Brain; Brain region; Brain-Derived Neurotrophic Factor; Caspase; Cell Line; Cell Survival; Cell physiology; Cells; Chelating Agents; Chronic; Clinical Trials; Complex; Dementia; Deposition; Development; Edetic Acid; Elderly; Elements; Emotional Stability; Fluorescence; Growth; Health; Hippocampus (Brain); Histocompatibility Antigens Class II; Homeostasis; Human; Immune; Incubated; Inflammation; Inflammatory; Investigation; Ions; Lead; Learning; Link; Maintenance; Measures; Mediating; Memory; Metals; Microglia; Molecular Conformation; Neocortex; Nervous system structure; Neurodegenerative Disorders; Neurofibrillary Tangles; Neuroglia; Neurons; Nitric Oxide Synthase; Oxidation-Reduction; Pathogenesis; Pathology; Pathway interactions; Pericytes; Play; Population; Process; Proteins; Rattus; Reporting; Risk Factors; Role; Senile Plaques; Signal Transduction; Spectrum Analysis; Stents; Structure; Surface; Testing; Thinness; Toxic effect; Trace Elements; Zinc; Zinc deficiency; abeta accumulation; abeta oligomer; abeta toxicity; base; brain cell; brain dysfunction; brain endothelial cell; cell type; cerebrovascular; clinical application; clinical investigation; cytotoxicity; design; drug discovery; immune function; mitochondrial dysfunction; mouse model; neocortical; nervous system disorder; neurotrophic factor; novel; novel strategies; pre-clinical; success; tau Proteins; tau phosphorylation; therapeutic target

Summary: “Zinc-Aβ interaction and its toxicity on brain cells” Zinc is essential for health and is the second abundant trace element in human brain. Zinc dyshomeostasis is implicated in the elderly population and Alzheimer’s disease (AD) which has many other risk factors besides Aβ and tau. Emerging evidence demonstrated that zinc also plays an important role in the pathogenesis of AD such as Aβ production and aggregation, tau phosphorylation, redox homeostasis, and brain-derived neurotrophic factor (BDNF) signaling. Zinc dyshomeostasis could be a therapeutic target for AD treatment. However, there are still controversies on the zinc concentration alteration, and the effect of zinc overload or zinc deficiency in AD patients, mouse models and cell lines. Providing these significant discrepancies across reported studies, more carefully-designed cellular, preclinical and clinical investigations are needed to portray a clearer picture of zinc’s role in AD development before clinical applications. Toward this end, we aim to investigate the interactions between zinc and Aβ, effect of zinc binding on Aβ aggregation, and the potential toxicity of Zn-chelated Aβ (ZnAβ) species on a variety of brain cells including neurons, microglia, astrocytes, and cerebrovascular cells in this one- year supplemental project.

摘要：“锌-Aβ 相互作用及其对脑细胞的毒性” 锌对健康至关重要，是人脑中第二丰富的微量元素。 与老年人群和阿尔茨海默病 (AD) 相关，除了 Aβ 之外，阿尔茨海默病还有许多其他危险因素 新的证据表明，锌在 AD 的发病机制中也发挥着重要作用。 如 Aβ 产生和聚集、tau 磷酸化、氧化还原稳态和脑源性神经营养 因子 (BDNF) 信号传导失调可能是 AD 治疗的一个治疗靶点。 关于锌浓度的变化以及锌超载或缺锌的影响仍存在争议。 AD 患者、小鼠模型和细胞系之间存在显着差异， 需要更仔细设计的细胞、临床前和临床研究来描绘更清晰的图景 为此，我们的目标是在临床应用之前研究锌在 AD 发展中的作用。 锌和 Aβ 之间的关系、锌结合对 Aβ 聚集的影响以及锌螯合 Aβ (ZnAβ) 的潜在毒性 多种脑细胞上的物种，包括神经元、小胶质细胞、星形胶质细胞和脑血管细胞 年补充项目。

项目成果

Designing Better Cardiovascular Stent Materials - A Learning Curve.

设计更好的心血管支架材料——学习曲线。

• 发表时间: 2021-01-04
• 影响因子: 19
• 作者: Cockerill, Irsalan;See, Carmine Wang;Young, Marcus L;Wang, Yadong;Zhu, Donghui
• 通讯作者: Zhu, Donghui

Alzheimer's pathogenic mechanisms and underlying sex difference.

阿尔茨海默病的致病机制和潜在的性别差异。

• 发表时间: 2021-06
• 作者: Zhu, Donghui;Montagne, Axel;Zhao, Zhen
• 通讯作者: Zhao, Zhen

Bioactive glass coatings on metallic implants for biomedical applications.

用于生物医学应用的金属植入物上的生物活性玻璃涂层。

• 发表时间: 2019-12
• 影响因子: 18.9
• 作者: Oliver, Joy;Su, Yingchao;Lu, Xiaonan;Kuo, Po;Du, Jincheng;Zhu, Donghui
• 通讯作者: Zhu, Donghui

Micro-/Nanotopography on Bioresorbable Zinc Dictates Cytocompatibility, Bone Cell Differentiation, and Macrophage Polarization.

生物可吸收锌的微/纳米形貌决定了细胞相容性、骨细胞分化和巨噬细胞极化。

• 发表时间: 2020
• 影响因子: 10.8
• 作者: Cockerill, Irsalan;Su, Yingchao;Lee, Ji Hyung;Berman, Diana;Young, Marcus L;Zheng, Yufeng;Zhu, Donghui
• 通讯作者: Zhu, Donghui

Zinc-Based Biomaterials for Regeneration and Therapy.

用于再生和治疗的锌基生物材料。

• DOI: 10.1016/j.tibtech.2018.10.009
• 发表时间: 2019-04-01
• 期刊: Trends in biotechnology
• 影响因子: 17.3
• 作者: Yingchao Su;I. Cockerill;Yadong Wang;Yi;Lingqian Chang;Yufeng Zheng;Donghui Zhu
• 通讯作者: Donghui Zhu