Biodegradable Synthetic Vascular Graft

可生物降解的合成血管移植物

基本信息

批准号：
9655087
负责人：
Yadong Wang
金额：
$ 1.1万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-25 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9655087
关键词：
Biodegradable Synthetic Vascular Graft

项目摘要

Abstract This research plan builds upon the progress made with prior NIH funding but strikes out in a brand new direction. The next period of the research aims at harnessing the body’s own healing capacity by creating cell-free synthetic grafts that can be rapidly remodeled by the host. The focus of the last funding period was cell-centered in vitro tissue engineering of arteries. The next stage of this project will completely bypass cell seeding and cell culture. We will use the cell-free polymer scaffolds directly as interposition grafts in abdominal aortas of mammalian hosts. The open porous graft will fully exploit the power of host remodeling more effectively than current vascular grafts that are dense and inhibit cell infiltration. The graft will function immediately as a non-thrombogenic conduit for blood flow in a similar fashion as a saphenous vein in coronary artery bypass surgery. We hypothesize that the extensive pores in the graft will facilitate host cell infiltration and the fast degrading polymer will enable rapid host remodeling to regenerate arteries in situ. This hypothesis is based on our strong preliminary data on rapid host cell infiltration and near complete regeneration of rat aorta 3 month post-implantation. The neo-arteries pulse synchronously with the host aorta and possess burst pressure and compliance comparable to native arteries. To our knowledge, this level of rapid host remodeling is unprecedented in reported vascular grafts. Three specific aims will test this hypothesis in the next five years: 1. Study the relationship between the structure of the porous tube and host remodeling of the vascular grafts. 2. Determine the impact of mechanical properties of sheath material on the performance of the vascular graft in vivo. And 3. Investigate host remodeling of the vascular grafts at the cellular level. Success in cell-free tissue engineering will accelerate clinical translation and ultimately benefit patients suffering myocardial and peripheral ischemia. Insights gained from this research will lead to new approaches in regeneration of complex organs in the future.

抽象的该研究计划建立在 NIH 先前资助所取得进展的基础上，但在下一阶段的研究旨在利用人体自身的治愈能力。通过创建可被宿主快速重塑的无细胞合成移植物来增强能力。上一个资助期是以细胞为中心的体外动脉组织工程，下一阶段。项目将完全绕过细胞接种和细胞培养，我们将使用无细胞聚合物支架。直接作为哺乳动物宿主腹主动脉的插入移植物。比目前致密的血管移植物更有效地充分利用宿主重塑的力量并抑制细胞浸润，移植物将立即充当非血栓形成的血液导管。其流动方式与冠状动脉搭桥手术中的隐静脉类似。移植物中的大孔将促进宿主细胞渗透，并且快速降解的聚合物将使宿主快速重塑以原位再生动脉这一假设是基于我们的强有力的。大鼠主动脉3个月快速宿主细胞浸润和近乎完全再生的初步数据植入后的新动脉与宿主主动脉同步搏动并具有爆发性。据我们所知，这种水平的快速宿主的压力和顺应性相当。所报道的血管移植物的重塑是前所未有的，三个具体目标将检验这一假设。未来五年： 1、研究多孔管的结构与 2. 确定血管移植物的机械性能的影响。鞘材料对血管移植物体内性能的影响 3.研究宿主。在细胞水平上重塑血管移植物将在无细胞组织工程中取得成功。加速临床转化，最终造福心肌和外周疾病患者从这项研究中获得的见解将带来恢复复杂性的新方法。未来的器官。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47.

针对普遍存在的细胞表面受体 CD47 的治疗机会。

DOI：
发表时间：
2013-01
期刊：
影响因子：
5.8
作者：
Soto;Stein, Erica V;Rogers, Natasha M;Sharifi;Isenberg, Jeffrey S;Roberts, David D
通讯作者：
Roberts, David D

A functionalizable polyester with free hydroxyl groups and tunable physiochemical and biological properties.

一种具有游离羟基和可调节的物理化学和生物特性的可官能化聚酯。

DOI：
10.1016/j.biomaterials.2010.01.023
发表时间：
2010-04
期刊：
Biomaterials
影响因子：
14
作者：
You, Zhengwei;Cao, Haiping;Gao, Jin;Shin, Paul H.;Day, Billy W.;Wang, Yadong
通讯作者：
Wang, Yadong

Substantial expression of mature elastin in arterial constructs.

成熟弹性蛋白在动脉结构中大量表达。