Biodegradable Elastomers and Resorbable Synthetic Vascular Grafts

可生物降解的弹性体和可吸收的合成血管移植物

基本信息

批准号：
10580321
负责人：
Xiaochu Ding
金额：
$ 46.95万
依托单位：
MICHIGAN TECHNOLOGICAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-03-15 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10580321
关键词：
Adhesions Alkynes Animal Model Animals Arteries Autologous Autologous Transplantation Blood Platelets Bypass Cause of Death Cell Culture Techniques Cells Chemistry Clinical Coronary Artery Bypass Data Data Analyses Deposition Diameter Disease Elasticity Elastomers Electrospinning Endothelium Engineering Evaluation Extracellular Matrix Female Fiber Future Glycerol Heparin Immobilization Immune response Implant In Situ In Vitro Infiltration Legal patent Length Modeling Modulus Molecular Weight Morphology Natural regeneration Outcome Patients Performance Peripheral Polyesters Polymers Porosity Positron-Emission Tomography Proliferating Property Rattus Regenerative capacity Research Resources Stains Stenosis Structure Sulfhydryl Compounds Surface Surgical sutures Techniques Temperature Tensile Strength Thick Thrombosis Tissues Training Tunica Adventitia Underrepresented Students Vascular Graft abdominal aorta absorption biodegradable polymer biomaterial compatibility caprolactone crosslink crystallinity design elastomeric fabrication hydrophilicity male mechanical properties monomer pediatric patients recruit scaffold sebacic acid serinol standard care thrombotic translational study undergraduate student

项目摘要

Project Summary Occlusive artery diseases are a leading cause of death worldwide. Only in the U.S., there are approximately 400,000 coronary artery bypasses and 460,000 peripheral artery bypasses performed each year. Autografts are the gold-standard treatment. However, approximately 1/3 of these patients are unable to take this treatment because of limited autologous resources. Nondegradable grafts (e.g., PET and ePTFE) have been alternative to the autografts over the years, but they perform poorly in small arteries (< 6 mm) due to thrombosis, stenosis, and low patency rate. On the other hand, bioresorbable grafts have been proposed for in situ arterial regeneration using the host regenerative capacities. The complications occurred in the nondegradable grafts can be minimized. However, none of the currently existing biodegradable polymers have produced a clinically useful resorbable graft. In this proposal, we seek to synthesize new biodegradable functional polyester elastomers and use to engineer fully resorbable synthetic grafts with tunable degradation, mechanical properties, and hydrophilicity. We expect the fully remodeled grafts can grow along with native arteries, which is particularly important for pediatric patients. There are three main objectives in this proposal. Objective 1: Design, synthesis and characterization of the biodegradable functional polyester elastomers using endogenous and biocompatible monomers. Objective 2: Engineer anti-thrombotic fibrous grafts with tunable degradation and mechanical properties. Objective 3: Evaluation of candidate grafts in rat abdominal aorta interposition models for in situ arterial regeneration. Data from this project will be used to optimize the graft parameters for large animal studies in the future, given a quicker degradation and slower regenerative capacities in large animals. Undergraduate students including underrepresented students will be recruited and trained to conduct research in this project, such as material synthesis and characterizations, graft fabrication and characterizations, cell culture studies, and tissue section, staining and data analyses, among others.

项目概要闭塞性动脉疾病是全世界死亡的主要原因。只有在美国，才有每年大约进行 400,000 例冠状动脉搭桥术和 460,000 例外周动脉搭桥术。自体移植是金标准治疗方法。然而，大约 1/3 的患者无法接受此治疗由于自体资源有限而无法进行治疗。不可降解的移植物（例如 PET 和 ePTFE）已被多年来作为自体移植物的替代品，但由于血栓形成，它们在小动脉（< 6 mm）中表现不佳，狭窄，通畅率低。另一方面，生物可吸收移植物已被提议用于原位动脉利用宿主的再生能力进行再生。并发症发生在不可降解的移植物上可以最小化。然而，目前现有的可生物降解聚合物还没有产生临床效果。有用的可吸收移植物。在本提案中，我们寻求合成新型可生物降解的功能性聚酯弹性体并用于设计具有可调节降解、机械性能和亲水性的完全可吸收合成移植物。我们期望完全重塑的移植物能够与天然动脉一起生长，这对于儿科患者。该提案有三个主要目标。目标 1：设计、合成和使用内源性和生物相容性表征可生物降解的功能性聚酯弹性体单体。目标 2：设计具有可调降解和机械性能的抗血栓纤维移植物特性。目标 3：原位大鼠腹主动脉介入模型中候选移植物的评价动脉再生。该项目的数据将用于优化大型动物研究的移植参数在未来，考虑到大型动物的退化速度更快，再生能力更慢。本科生将招募和培训包括代表性不足的学生在内的学生在该项目中进行研究，例如材料合成和表征、移植物制造和表征、细胞培养研究，以及组织切片、染色和数据分析等。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pair of Functional Polyesters That Are Photo-Cross-Linkable and Electrospinnable to Engineer Elastomeric Scaffolds with Tunable Structure and Properties.

一对可光交联和静电纺丝的功能性聚酯，可设计具有可调节结构和性能的弹性支架。

DOI：
10.1021/acsabm.3c00894
发表时间：
2024-01-11
期刊：
ACS applied bio materials
影响因子：
4.7
作者：
Xiaochu Ding;Zhongtian Zhang;Christopher Kluka;Saad Asim;James Manuel;Bruce P Lee;Jingfeng Jiang;Patricia A Heiden;C. Heldt;Muhammad Rizwan
通讯作者：
Muhammad Rizwan