Mammalian bile acid detection, processing, and impact on social behavior

哺乳动物胆汁酸检测、处理及其对社会行为的影响

基本信息

批准号：
10222213
负责人：
Julian P Meeks
金额：
$ 42.57万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10222213
关键词：
Accessory Olfactory Bulbs Afferent Neurons Animals Anxiety Area Behavior Behavior assessment Behavioral Behavioral Paradigm Bile Acids Biochemical Biological Brain Brain imaging Brain region Calcium Cells Chemicals Cholesterol Chromosome Mapping Complement Coprophagia Coupled Cues Data Detection Diet Dietary Fats Digestion Disease Environment Esthesia Evolution Family Fatty acid glycerol esters Feces Foundations G-Protein-Coupled Receptors GPBAR1 gene Gene Expression Glucocorticoids Goals Health Human Image Imaging Techniques Immediate-Early Genes In Situ Hybridization Individual Kairomones Knowledge Laboratories Learning Life Link Liver Mammals Maternal Behavior Measures Metabolic Metabolism Methods Moods Mus Neurons Nose Olfactory Pathways Pattern Peripheral Pheromone Physiology Population Positioning Attribute Process Production Property Reproduction Reproductive Behavior Research Research Proposals Rodent Rodent Control Role Sensory Sensory Receptors Signal Transduction Social Behavior Source Steroids Sulfate Techniques Testing Urine Vitamins absorption base behavioral response brain pathway experimental study gut microbes improved information processing insight microorganism mitral cell neural circuit neuromechanism next generation receptor reproductive sensory system sex social anxiety transcriptome transcriptome sequencing urinary vomeronasal organ

项目摘要

Project Summary/Abstract The overall goal of this research plan is to improve understanding about mammalian bile acid chemosignaling through the accessory olfactory system (AOS). Bile acids – well known regulators of fat digestion and metabolism – also serve as external chemosignals for the AOS. In most mammals, the AOS directly influences brain regions that control anxiety and social behaviors, and understanding this brain pathway is likely to provide insights into mammalian sexual/reproductive drive, social anxiety, and moods. New knowledge about AOS function may be utilized to help control rodent populations, including those that harbor harmful microorganisms. The mechanisms of peripheral bile acid sensation, the mechanisms of bile acid information processing in the brain, and the behavioral impacts of bile acids are currently unknown. The proposed research will combine new calcium imaging techniques with transcriptome analysis to identify the peripheral AOS receptor(s) sensitive to bile acids. Other proposed experiments will investigate network properties in accessory olfactory bulb (AOB), where bile acid and other steroid information is integrated. Finally, behavioral assessment will be coupled to brain-wide immediate early gene mapping to determine the overall impacts of bile acid chemosensation on brain activity and behavior. The proposed research will investigate these topics in order to improve understanding of this important class of mammalian chemosignals. The results of the proposed experiments will ultimately benefit human health by linking mammalian gut physiology to brain function.

项目概要/摘要该研究计划的总体目标是提高对哺乳动物胆汁酸化学信号传导的了解通过辅助嗅觉系统（AOS）——众所周知的脂肪消化和调节作用。新陈代谢 – 也作为 AOS 的外部化学信号在大多数哺乳动物中，AOS 直接影响。控制焦虑和社交行为的大脑区域，了解这一大脑通路可能会提供有关哺乳动物性/生殖欲、社交焦虑和情绪的新知识。 AOS 功能可用于帮助控制啮齿动物种群，包括那些携带有害物质的啮齿动物种群。微生物。外周胆汁酸感觉的机制，胆汁酸信息的机制。目前尚不清楚大脑中的处理过程以及胆汁酸的行为影响。研究将新的钙成像技术与转录组分析相结合，以识别外周血其他提议的实验将研究对胆汁酸敏感的 AOS 受体的网络特性。辅助嗅球（AOB），其中整合胆汁酸和其他类固醇信息最后，行为。评估将与全脑立即早期基因图谱结合起来，以确定总体影响胆汁酸化学感觉对大脑活动和行为的影响。拟议的研究将调查这些主题。为了提高对这一类重要的哺乳动物化学信号的理解。拟议的实验将通过将哺乳动物肠道生理学与大脑联系起来，最终造福人类健康功能。