FUNCTIONAL ORGANIZATION OF NEURAL CIRCUITS IN THE MOUSE ACCESSORY OLFACTORY BULB

小鼠附件嗅球神经回路的功能组织

基本信息

批准号：
8477017
负责人：
Julian P Meeks
金额：
$ 23.61万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8477017
关键词：
Accessory Olfactory Bulbs Affect Afferent Neurons Aggressive behavior Animals Award Axon Behavior Brain Brain region Calcium Cells Chemical Structure Chemicals Code Cytoplasmic Granules Data Dendritic Cells Esthesia Fluorescence Foundations Genetic Markers Goals Green Fluorescent Proteins Image Individual Interneurons Juxtaglomerular Cell Knowledge Life Ligands Light Lighting Link Location Maps Mentors Methods Microscopy Modality Modeling Mus Neural Pathways Neurons Neuropil Nose Odors Optics Output Partner in relationship Pattern Pattern Recognition Peripheral Phase Population Positioning Attribute Presynaptic Terminals Process Production Property Relative (related person)Reproductive Behavior Research Research Personnel Research Proposals Research Training Role Scientist Sensory Sensory Process Shapes Smell Perception Social Behavior Specialist Stimulus Synapses System Techniques Testing Time Training Transgenic Animals Transgenic Mice Variant abstracting career cell type design experience improved information processing inhibitory neuron innovation insight neural circuit post-doctoral training receptive field receptor research study response sensory neuroscience sensory stimulus sensory system social spatial relationship tool

项目摘要

PROJECT SUMMARY/ABSTRACT The overall goal of this research and training plan is to gain better understanding of the organization and function of the mouse accessory olfactory system (AOS). The AOS is a compact neural pathway that communicates directly with brain regions that govern so-called "intrinsic" social and reproductive behaviors. By increasing knowledge about sensory processing in the mouse AOS, this project will shed light on principles of mammalian olfaction, and will improve our understanding of links between sensation and behavior. The investigator, Dr. Julian Meeks, will gain up to two years of advanced postdoctoral training in the design and implementation of planar illumination microscopy and transgenic mice in support of an innovative approach using live neuronal calcium imaging to study inhibitory interneurons in the mouse accessory olfactory bulb. Two sponsors for this training were chosen, Dr. Timothy Holy and Dr. Daniel Kerschensteiner, that have strong experience in the fields of optical design and transgenic mouse production, respectively. Several hypotheses will be tested during the mentored and independent phases of this award. One main hypothesis links sensory "receptive fields" to axonal projection patterns in the brain. Testing several other hypotheses will identify specific sensory processing roles for the various interneuron populations in the accessory olfactory bulb. Testing these hypotheses will establish principles of mammalian social odor processing, and will help us to understand the functions that inhibitory neurons provide for sensory neural circuits. Through this research and mentored training plan, Dr. Meeks will produce valuable new data on AOS sensory processing, and will establish new experimental tools and approaches that will form a foundation for a career as an independent scientist.

项目概要/摘要本研究和培训计划的总体目标是更好地了解组织和小鼠辅助嗅觉系统（AOS）的功能。 AOS 是一条紧凑的神经通路直接与控制所谓“内在”社会和生殖行为的大脑区域进行通信。经过通过增加有关小鼠 AOS 感觉处理的知识，该项目将阐明以下原理：哺乳动物的嗅觉，并将提高我们对感觉和行为之间联系的理解。研究人员 Julian Meeks 博士将获得长达两年的高级博士后设计培训以及平面照明显微镜和转基因小鼠的实施，以支持创新使用活神经元钙成像研究小鼠副嗅觉中的抑制性中间神经元的方法电灯泡。本次培训的两位赞助商是 Timothy Holy 博士和 Daniel Kerschensteiner 博士，他们分别在光学设计和转基因小鼠生产领域拥有丰富的经验。在该奖项的指导和独立阶段将测试几个假设。一个主假设将感觉“感受野”与大脑中的轴突投射模式联系起来。测试其他几个假设将确定不同中间神经元群体的特定感觉处理作用附件嗅球。测试这些假设将建立哺乳动物社交气味的原理处理，并将帮助我们理解抑制性神经元为感觉神经提供的功能电路。通过这项研究和指导培训计划，米克斯博士将产生有关 AOS 的宝贵新数据感官处理，并将建立新的实验工具和方法，为作为一名独立科学家的职业生涯。