Biomedical Informatics Core

生物医学信息学核心

• 批准号: 10201622
• 负责人: Lucio Miele
• 金额: $ 32.51万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2022-08-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201622
• 关键词: Academic Medical Centers; Address; Affect; Alabama; Applications Grants; Big Data; Bioinformatics; Biology; Biomedical Research; Biometry; Center for Translational Science Activities; Centers of Research Excellence; Chronic Disease; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Collaborations; Communication; Communities; Data; Data Science; Data Set; Data Storage and Retrieval; Databases; Dental Schools; Development; Disease; Epidemiology; Ethics; Evaluation; Facility Designs; Funding; Generations; Genomics; Goals; Health; Health Sciences; Health system; Healthcare Systems; Informatics; Infrastructure; Institution; Knowledge; Link; Louisiana; Medical; Mission; Molecular Epidemiology; Nursing Schools; Outcome; Pathologic; Patients; Productivity; Publications; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Role; Services; Source; South Carolina; Translational Research; Twin Multiple Birth; Underserved Population; Universities; Veterans; Vulnerable Populations; analytical tool; base; biobank; biomedical informatics; burden of illness; clinical center; clinical data warehouse; cohort; cyber infrastructure; data integration; data mining; data sharing; database design; design; experience; genomic data; health literacy; improved; informatics infrastructure; innovation; multiple data sources; novel; precision medicine; programs; research facility; research study; skills; tumor registry; virtual

PROJECT SUMMARY: BIOMEDICAL INFORMATICS (BMI) CORE The mission of the Biomedical Informatics (BMI) Key Component Activity (KCA) of the Louisiana Clinical and Translational Science Center (LA CaTS) is to develop and deploy “state of the art” biomedical informatics capabilities and services across all partner institutions, in support of clinical and translational research aimed at improving health outcomes and addressing disparities in our most vulnerable populations. Over the past 4 years, the BMI KCA supported 55 LA CaTS Investigators across 14 institutions, resulting in 27 publications and 7 funded grant applications. During the next funding period, the BMI KCA will pursue several innovative goals: 1) the creation of i2b2-searchable “virtual cohorts” for diseases disproportionately affecting Louisiana patients; 2) the participation in the Southeast SHRINE and TriNetX clinical data networks; 3) the integration of genomic, pathologic and clinical datasets; and 4) the creation of a searchable “virtual biorepository” linking physical biorepositories across LA CaTS institutions. We will leverage key collaborations with: PCORI-funded REACHnet; UAB- and Medical University of South Carolina (MUSC)-led CTSA Centers; the Precision Medicine and Bioinformatics Programs at LSUHSC-New Orleans, and the Louisiana Tumor Registry (LTR). We are excited about expanding our services to our LA CaTS new partner institutions: the LSUHSC Dental and Nursing Schools, the Southeast Louisiana Veterans Healthcare System, the University Medical Center in New Orleans and Ochsner Health System. To accomplish our mission, we propose the following aims: Specific Aim 1. To significantly expand ongoing BMI services and to build on our experience to develop novel analytical tools for data mining, precision medicine and molecular epidemiology. Specific Aim 2. To expand our ability to enable meaningful collaboration and data sharing between LA CaTS Investigators and Louisiana-based Louisiana Biomedical Research Network (LBRN) and Centers of Biomedical Research Excellence (COBRE) Centers, and between LA CaTS Investigators and CTSA Centers regionally and nationally, and to increase cyber access to underserved populations. Specific Aim 3. To provide continued, coordinated support for project design and implementation and professional development, in close cooperation with the Clinical Research Resources (CRR), Design, Epidemiology and Biostatistics (DEB), Cyberinfrastructure Enhancement (CE), Professional Development (PD), Ethics and Regulatory Knowledge (ERKC) and Health Literacy (HL) KCAs.

项目摘要：生物医学信息学 (BMI) 核心 路易斯安那临床和生物医学信息学 (BMI) 关键成分活动 (KCA) 的使命 转化科学中心 (LA CaTS) 将开发和部署“最先进的”生物医学信息学 所有合作机构的能力和服务，以支持旨在实现以下目标的临床和转化研究： 过去 4 年来改善健康状况并解决最弱势群体的差异。 多年来，BMI KCA 支持了 14 个机构的 55 名 LA CatS 调查员，发表了 27 篇出版物和 7 项资助的赠款申请 在下一个资助期内，BMI KCA 将追求几个创新目标： 1) 针对严重影响路易斯安那州患者的疾病创建 i2b2 可搜索“虚拟队列”； 2）参与东南SHRINE和TriNetX临床数据网络；3）整合基因组、 病理和临床数据集；4）创建连接物理的可搜索“虚拟生物存储库” 我们将利用与以下机构的重要合作： PCORI 资助的。 REACHnet；UAB 和南卡罗来纳医科大学 (MUSC) 领导的精准医学中心； 路易斯安那州立大学医学中心新奥尔良分校和路易斯安那州肿瘤登记处 (LTR) 的生物信息学项目。 很高兴将我们的服务扩展到 LA CatS 新合作机构：LSUHSC 牙科和 护理学校、路易斯安那州东南部退伍军人医疗保健系统、新州大学医疗中心 奥尔良和奥克斯纳卫生系统为了完成我们的使命，我们提出以下目标： 具体目标 1. 显着扩展正在进行的 BMI 服务，并基于我们的经验开发新颖的 数据挖掘、精准医学和分子流行病学的分析工具。 具体目标 2. 扩展我们在 LA CaTS 之间实现有意义的协作和数据共享的能力 研究人员和位于路易斯安那州的路易斯安那州生物医学研究网络 (LBRN) 和生物医学中心 研究卓越 (COBRE) 中心，以及 LA CatTS 调查员和区域 CTSA 中心之间 在全国范围内，并增加对服务不足的人群的网络访问。 具体目标 3. 为项目设计和实施提供持续、协调的支持 专业发展，与临床研究资源（CRR）密切合作，设计， 流行病学和生物统计学（DEB）、网络基础设施增强（CE）、专业发展 (PD)、道德与监管知识 (ERKC) 和健康素养 (HL) KCA。