Understanding and Addressing Cancer Health Disparities in Louisiana

了解并解决路易斯安那州的癌症健康差异

基本信息

批准号：
10005206
负责人：
Lucio Miele
金额：
$ 96.85万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-19 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10005206
关键词：
Address Affect African American Area Biological Biological Factors Biology Breast Cancer Patient Cancer Biology Cancer Center Cancer Center Planning Grant Cancer Etiology Characteristics Chemotherapy-Oncologic Procedure Clinical Clinical Trials Complex Data Diagnosis Disease Disease Outcome Elements Endometrial Endometrial Carcinoma Ensure Environmental Risk Factor Epidemiology Future Genetic Genomics Goals Grant Immunity Immunologics Immunology Immunotherapy Impairment In complete remission Incidence Inequality Infiltration Inflammation Inflammatory Infrastructure Institution Intervention Investigation Leadership Light Literature Liver Louisiana Malignant Neoplasms Measurable Medical Metabolic Metabolism Minority Mutation Myeloid-derived suppressor cells Neoadjuvant Therapy Not Hispanic or Latino Obesity Outcome Pathologic Patient-Focused Outcomes Patients Pharmaceutical Preparations Politics Population Portraits Prevention Preventive Intervention Primary carcinoma of the liver cells Prognostic Marker Public Health Renal Cell Carcinoma Renal carcinoma Research Research Personnel Research Project Grants Research Support Role Socioeconomic Factors Stress Survival Rate T cell response Testing Therapeutic Intervention Transcript Treatment Efficacy Tumor Biology Tumor Immunity Tumor-infiltrating immune cells Underserved Population Woman Work advanced prostate cancer cancer health disparity cancer therapy chemotherapy comorbidity economic determinant fatty acid oxidation genomic signature gulf coast health care availability health disparity improved improved outcome inhibitor/antagonist insight malignant breast neoplasm molecular subtypes mortality novel novel diagnostics novel strategies novel therapeutic intervention novel therapeutics nutrition patient population resistance mechanism response social health determinants socioeconomics success tool triple-negative invasive breast carcinoma tumor

项目摘要

ABSTRACT: Cancer health disparities represent a major public health crisis in the state of Louisiana and the Gulf Coast. The citizens of this region have to contend with cancer incidence and mortality rates that are among the highest in the nation. In addition, we have a very high incidence of specific malignancies that disproportionately affect minorities and the underserved citizens of the region. Triple negative breast cancer, hepatocellular carcinoma, endometrial cancer, advanced prostate cancer, renal cell carcinoma, among others, are more common and appear to be more aggressive among minorities. Complex socio-economic and political reasons and an increase in co-morbidities, such as obesity, may in part help explain the origin of some of these health disparities. However, increasing evidence from genomics and cancer biology, including our work, has started to shed light on the biological basis for some of these inequities, and suggests specific interventions to help ameliorate the impact of these diseases and improve patient outcomes. We plan to use this P20 planning grant to establish research projects that bring together the best investigators and institutions in Louisiana who are conducting research on the genetics/genomics, immunology, and clinical and public health aspects of cancer with special emphasis on health disparities. Under the leadership of the LSU Stanley S. Scott Cancer Center in New Orleans (LSU-CC-NO) and in partnership with investigators from academic and medical institutions in the state, we have agreed to conduct research under the new Gulf South Center for Research and Solutions in Cancer Health Disparities (Gulf South-CARES-CHD). To ensure a focused and productive effort, this P20 grant we will study the genomic signature and inflammation characteristics of triple negative breast cancer (TNBC), a disease that disproportionately affects young African-American women in Louisiana. We believe that understanding the genomics and inflammatory biology of specific cancers may provide insights into mechanisms of resistance to neoadjuvant chemotherapy and help identify and test potential interventions for improving the therapeutic efficacy of current and future treatments. Besides creating competitive teams of researchers, we will build the necessary intellectual and organizational infrastructure and develop the preliminary data to plan and support research projects that qualify for a SPORE application. Our combined expertise, the unique patient populations available in Louisiana, and the commitment of our institutions will enable us to achieve these goals, which will improve prevention, diagnosis and treatment of cancer in underserved populations, both in Louisiana and globally.

抽象的：癌症健康差异是路易斯安那州和墨西哥湾沿岸的重大公共卫生危机。该地区的居民必须应对癌症发病率和死亡率处于世界前列的癌症发病率和死亡率。全国最高。此外，我们的特定恶性肿瘤发病率非常高，该地区的少数民族和服务不足的公民受到的影响尤为严重。三阴性乳腺癌，肝细胞癌、子宫内膜癌、晚期前列腺癌、肾细胞癌等其他的则更常见，并且在少数族裔中似乎更具攻击性。复杂的社会经济政治原因以及肥胖等合并症的增加可能在一定程度上有助于解释其中一些健康差异。然而，来自基因组学和癌症生物学的越来越多的证据，包括我们的工作已开始阐明其中一些不平等的生物学基础，并提出了具体的建议干预措施有助于减轻这些疾病的影响并改善患者的治疗结果。我们计划使用这项 P20 规划拨款用于建立研究项目，汇集最优秀的研究人员和路易斯安那州正在进行遗传学/基因组学、免疫学和临床研究的机构以及癌症的公共卫生方面，特别强调健康差异。在团领导的带领下新奥尔良路易斯安那州立大学斯坦利·S·斯科特癌症中心 (LSU-CC-NO) 并与来自以下机构的研究人员合作该州的学术和医疗机构，我们已同意在新海湾下进行研究南方癌症健康差异研究和解决方案中心（Gulf South-CARES-CHD）。为确保通过专注且富有成效的努力，这笔 P20 资助我们将研究基因组特征和炎症三阴性乳腺癌 (TNBC) 的特征，这种疾病不成比例地影响年轻人路易斯安那州的非裔美国妇女。我们相信，了解基因组学和炎症特定癌症的生物学可能提供对新辅助化疗耐药机制的见解并帮助识别和测试潜在的干预措施，以提高当前和未来的治疗效果治疗。除了创建有竞争力的研究团队外，我们还将建立必要的智力和组织基础设施并开发初步数据来规划和支持研究项目有资格申请 SPORE。我们综合的专业知识、独特的患者群体路易斯安那州以及我们机构的承诺将使我们能够实现这些目标，这将改善路易斯安那州和全球服务不足人群的癌症预防、诊断和治疗。