Digital Markers of Cognition Across the Spectrum of Preclinical Cognitive Impairment to Dementia

痴呆症临床前认知障碍范围内的认知数字标记

• 批准号: 10190755
• 负责人: Stacy Andersen
• 金额: $ 11.91万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10190755
• 关键词: Aging; Applications Grants; Award; Behavioral; Biometry; Boston; Brain; Brain Pathology; Characteristics; Clinical; Cognition; Cognitive; Cognitive aging; Cohort Studies; Collaborations; Communication; Complement; Computer software; Data; Data Collection; Dementia; Development; Diagnostic; Diffusion; Digital Signal Processing; Early Diagnosis; Early Intervention; Early treatment; Epidemiologist; Family; Family Study; Family member; Five-Year Plans; Framingham Heart Study; Functional Magnetic Resonance Imaging; Funding; General Population; Genetic; Gerontology; Goals; Grant; Hippocampus (Brain); Human; Image; Impaired cognition; Impairment; Incidence; Individual; Institutes; Investigation; K-Series Research Career Programs; Knowledge; Life; Linguistics; Literature; Longevity; Magnetic Resonance Imaging; Measures; Medicine; Mentors; Mentorship; Methods; Motor; Nerve Degeneration; Neurodegenerative Disorders; Neuropsychological Tests; Neuropsychology; Participant; Pattern; Performance; Persons; Phenotype; Physical Function; Process; Production; Protocols documentation; Publishing; Research; Rest; Semantics; Sensitivity and Specificity; Speech; Speed; Statistical Data Interpretation; Structure; Study Subject; Technology; Testing; Thick; Training; Translations; Tremor; Universities; Variant; Voice; Work; Writing; apprenticeship; base; behavior measurement; career; career development; clinical phenotype; clinically relevant; cognitive change; cognitive function; cognitive performance; cohort; computerized; connectome; digital; effective intervention; experience; follow-up; healthspan; healthy aging; indexing; informal learning; medical schools; meetings; neural network; neuroimaging; neuroimaging marker; neuropsychiatry; novel; performance tests; pre-clinical; predictive marker; preservation; professor; prospective; resilience; response; skills; voice recognition; white matter

ABSTRACT Stacy L. Andersen is an Assistant Professor in the Department of Medicine at Boston University School of Medicine. She seeks a mentored career development award (K01) to obtain critical knowledge skills in biostatistics, communication patterns, neuropsychological assessment, and neuroimaging, particularly as they relate to cognitive aging, and necessary research experience leading to an independent career as a neuroscientist in field of aging research, specifically in the field of healthy aging and cognitive resilience. The training proposal details a five-year plan of formal and informal instruction in the pathophysiologic basis of brain changes associated with aging and neurodegenerative disease as well as training in biostatistics and analysis methods. Dr. Andersen’s mentors, established experts in the fields of neuropsychology, neuroimaging, and gerontology have met with Dr. Andersen to formulate a plan of course work, guided study, seminars and academic meetings. Short-term career goals include to complete course work in linguistics, neuroimaging methods, and statistical analysis, disseminate high quality mentored research findings via presentations and published works, engage in career development activities and to apply for independent R grant funding early in the fifth year of the award period. Long-term career goals are to be an independent neuropsychiatric epidemiologist with content expertise in the neuropsychological assessment of long-lived individuals, novel applications of technology for evaluating cognitive function, and factors associated with cognitive resilience. The specific aims of the proposed research are to (1) with specialized software, extract cognitive performance metrics from digital voice recordings and digitally-captured motor performance, (2) test the hypothesis that digital metrics of speech and motor production are sensitive to variations in cognitive function and clinical dementia status, (3) test the hypothesis that digital metrics of speech and motor production are associated with neuroanatomical substrates as detected by structural and functional MRI, and (4) institute prospective data collection of longitudinal, digitally-acquired neuropsychological test data. This study has the potential to identify digital metrics as correlates of cognitive function and possibly early markers of cognitive change allowing for earlier diagnosis and intervention. Completion of the proposed aims will provide preliminary findings that will lay the groundwork for a grant application investigating the association of longitudinal changes in traditional and digital neuropsychological metrics with incidence of cognitive impairment and dementia as well as the factors associated with an absence of longitudinal cognitive change (i.e., cognitive resilience).

抽象的 Stacy L. Andersen 是波士顿大学医学院医学系助理教授 她寻求指导职业发展奖（K01）以获得医学方面的关键知识技能。 生物统计学、沟通模式、神经心理学评估和神经影像学，特别是当它们 认知老化，以及必要的相关研究经验，从而获得独立的职业生涯 衰老研究领域的神经科学家，特别是健康衰老和认知弹性领域。 培训提案详细介绍了病理生理学基础正式和非正式教学的五年计划 与衰老和神经退行性疾病相关的大脑变化以及生物统计学和 安徒生博士的导师，神经心理学领域的知名专家， 神经影像学和老年学与安德森博士会面，制定了课程作业、指导学习、 研讨会和学术会议。短期职业目标包括完成语言学课程， 神经影像方法和统计分析，通过以下方式传播高质量的指导研究成果 演讲和发表作品，从事职业发展活动并申请独立研究 在奖励期的第五年早期提供资金，长期职业目标是成为一名独立的人。 神经精神流行病学家，在长寿的神经心理学评估方面拥有专业知识 个人、评估认知功能的技术的新应用以及与认知功能相关的因素 认知弹性。 本研究的具体目标是（1）使用专门的软件，提取认知 来自数字录音和数字捕获的运动性能的性能指标，(2) 测试 假设言语和运动产生的数字指标对认知功能的变化敏感 和临床痴呆状态，（3）检验以下假设：言语和运动产生的数字指标是 与结构和功能 MRI 检测到的神经解剖学基质相关，以及 (4) 研究所 本研究对纵向、数字化获取的神经心理学测试数据进行前瞻性数据收集。 识别数字指标作为认知功能的相关性和可能的​​早期认知标记的潜力 改变允许早期诊断和干预。 完成拟议目标将提供初步调查结果，为拨款奠定基础 应用研究传统和数字神经心理学纵​​向变化的关联 认知障碍和痴呆发生率的指标以及与缺勤相关的因素 纵向认知变化（即认知弹性）。