University of Michigan BACPAC Mechanistic Research Center

密歇根大学BACPAC机理研究中心

• 批准号: 10202826
• 负责人: Daniel J Clauw
• 金额: $ 7.11万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-26 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202826
• 关键词: Area; Award; Back Pain; Characteristics; Chronic low back pain; Development; Environment; Evaluation; Individual; Intervention; Michigan; Modification; Pain Research; Participant; Patients; Pharmaceutical Preparations; Phenotype; Predictive Factor; Provider; Recording of previous events; Research; Review Literature; Training; Trauma; Treatment Efficacy; Universities; Work; chronic pain patient; clinical pain; cohort; effective intervention; experience; individualized medicine; interest; nondrug therapy; pain patient; parent grant; programs; response; theories; treatment planning

PROJECT SUMMARY/ABSTRACT The parent grant was awarded as a HEAL Initiative award, specifically as part of the Back Pain Consortium (BACPAC) Research Program (FOA: AR19-026). The current proposal will supplement the University of Michigan Mechanistic Research Center (UM MRC; U19 AR076734-01). The UM MRC aims to perform interventional response phenotyping in a cohort of chronic low back pain (cLBP) patients. Interventional response phenotyping describes the critical need to attain high quality information on each participant regarding to which drug and non-drug therapies they do and do not respond. This need extends to psychotherapeutic interventions, which are often used for the treatment of cLBP. This proposal will provide one year of support for the candidate to attain focused training in clinical pain research, including exploring differential response to psychotherapeutic interventions. Successful completion of this work will provide the HEAL Initiative with an extensive systematic literature review examining baseline phenotypic factors that predict differential responsiveness to the some of the most commonly used psychotherapeutic interventions for cLBP. The training plan will allow the candidate to: 1) understand the theory underlying and execution of some of the most commonly used psychotherapeutic interventions for cLBP; 2) develop expertise in phenotypic differences among patients with cLBP that might impact interventional efficacy; and 3) understand the patient and provider experience in order to promote the development and implementation of effective interventions for cLBP. The candidate will work with the PIs of the parent grant, Drs. Afton Hassett and Daniel Clauw, to complete this comprehensive training and research plan. Combined with the rich environment of the University of Michigan, this award will provide focused training to establish a unique niche of expertise and an independent research program focused on intervention modification, development, and evaluation for chronic pain patients with a history of trauma, the candidate’s primary area of interest.

项目概要/摘要 家长补助金被授予 HEAL Initiative 奖，特别是作为 Back 计划的一部分 疼痛联盟 (BACPAC) 研究计划 (FOA: AR19-026)。 将补充密歇根大学机械研究中心（UM MRC；U19 AR076734-01）。UM MRC 旨在进行干预反应表型分析。 慢性腰痛 (cLBP) 患者的干预反应表型队列。 描述了获得每个参与者的高质量信息的迫切需要 这种需求延伸到他们对哪些药物和非药物疗法有反应。 心理治疗干预，通常用于治疗 cLBP。 提案将为候选人提供一年的支持，以获得以下领域的集中培训： 临床疼痛研究，包括探索不同的心理治疗反应 这项工作的成功完成将为 HEAL 倡议提供一个机会。 广泛的系统文献综述检查预测的基线表型因素 对一些最常用的心理治疗的反应不同 cLBP 的干预措施 培训计划将使候选人能够： 1) 了解 一些最常用的心理治疗的基础理论和执行 cLBP 的干预措施；2) 培养有关 cLBP 患者表型差异的专业知识 可能影响介入疗效的 cLBP；以及 3) 了解患者和提供者 以促进经验的制定和实施的有效性 候选人将与家长资助的 PI 合作，Afton 博士。 哈塞特和丹尼尔·克劳，完成了这一全面的培训和研究计划。 结合密歇根大学丰富的环境，该奖项将提供 集中培训以建立独特的专业知识和独立研究 项目重点关注慢性疼痛的干预措施修改、开发和评估 有外伤史的患者，是候选人的主要兴趣领域。