Administrative Core

行政核心

基本信息

批准号：
10176342
负责人：
Victor Henderson
金额：
$ 77.42万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10176342
关键词：
Adopted Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Alzheimer’s disease biomarker Biological Brain Caregivers Caring Clinical Cognition Collaborations Communities Data Data Storage and Retrieval Dementia Dementia with Lewy Bodies Development Diagnosis Early Diagnosis Ensure Evaluation Genetic Goals Guidelines Health Professional Hispanics Impaired cognition Individual Infrastructure Institutional Review Boards Interdisciplinary Study Leadership Lewy Bodies Lewy body pathology Lewy neurites Link Microscopic Minority Groups Mission Monitor National Institute on Aging Nerve Degeneration Neurofibrillary Tangles Parkinson Disease Parkinson&apos s Dementia Participant Pathologic Pathology Phenotype Policies Procedures Process Reporting Research Research Personnel Research Training Resource Sharing Resources Risk Site Specimen Structure Time United States National Institutes of Health Universities Update age related aging brain alpha synuclein data exchange disparity reduction ethnic minority population high risk improved innovation mild cognitive impairment next generation pre-clinical prevent racial minority ranpirnase repository

项目摘要

1. SUMMARY (Administrative Core) The Stanford Alzheimer's Disease Research Center (ADRC) will support goals of the National Alzheimer's Project Act by serving as a shared resource to facilitate and enhance interdisciplinary and multidisciplinary research on Alzheimer's disease and Alzheimer's disease related dementia (AD/ADRD). At the Stanford ADRC, the focus will be on AD and a common ADRD, namely cognitive impairment and dementia linked to Lewy bodies, Lewy neurites, and the abnormal accumulation and propagation of alpha-synuclein (the Lewy body spectrum of neurodegenerative cognitive impairment). The Stanford ADRC has adopted a strategy of deep phenotyping, which draws together multiple levels of biological data on individual participants followed over time and culminating in brain donation. The Administrative Core provides the administrative structure needed to direct, facilitate and support the Stanford ADRC mission. It establishes the overall scientific direction, provides a forum for planning, ensures optimal resource utilization, and assures compliance with institutional and NIH policy requirements. It will accomplish these goals during the next five years through four specific aims: (1) Provide an infrastructure that establishes priorities and goals of the P30 Stanford ADRC: coordinate activities of ADRC cores and committees; ensure compliance with reporting procedures, policies, and guidelines of the NIH, institutional review board, and other relevant bodies; oversee data transfer to the National Alzheimer's Coordinating Center (NACC) and other entities; and oversee the transfer of biological specimens and genetic data to the National Centralized Repository for Alzheimer's Disease (NCRAD), National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), and other collaborating groups; (2) Stimulate innovative research on AD/ADRD by existing and new investigators, including the solicitation, evaluation, selection, and monitoring of development projects supported by the Center; (3) Provide leadership opportunities for the next generation of ADRC leaders; and (4) Promote research, training, and educational collaborations with other ADRCs, universities, health professionals, caregiver organizations, and the wider scientific and lay communities.

1. 概要（管理核心）斯坦福阿尔茨海默病研究中心 (ADRC) 将支持国家阿尔茨海默病目标项目法作为共享资源促进和加强跨学科和多学科阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）的研究。在斯坦福大学 ADRC，重点是 AD 和常见的 ADRD，即与以下疾病相关的认知障碍和痴呆路易体、路易神经突以及 α-突触核蛋白（路易体）的异常积累和传播神经退行性认知障碍的身体谱）。斯坦福大学 ADRC 采取了一项战略：深度表型分析，将个体参与者的多个级别的生物数据汇集在一起随着时间的推移，最终实现大脑捐赠。行政核心提供行政结构需要指导、促进和支持斯坦福 ADRC 的使命。它建立了整体科学指导，提供规划论坛，确保最佳资源利用，并确保遵守机构和 NIH 政策要求。它将在未来五年内通过四年来实现这些目标具体目标： (1) 提供基础设施，确定 P30 斯坦福 ADRC 的优先事项和目标：协调 ADRC 核心和委员会的活动；确保遵守报告程序、政策、以及 NIH、机构审查委员会和其他相关机构的指导方针；监督数据传输到国家阿尔茨海默病协调中心 (NACC) 和其他实体；并监督生物的转移样本和遗传数据存入国家阿尔茨海默氏病集中存储库 (NCRAD) 阿尔茨海默病衰老遗传学研究所数据存储站点 (NIAGADS) 和其他合作机构团体； (2) 促进现有和新的研究者对 AD/ADRD 的创新研究，包括征集、评估、选择和监测中心支持的发展项目； (3) 提供为下一代 ADRC 领导人提供领导机会； (4) 促进研究、培训和与其他 ADRC、大学、卫生专业人员、护理人员组织的教育合作，以及更广泛的科学界和非专业界。