Clinical Sciences Core

临床科学核心

• 批准号: 10155400
• 负责人: Babafemi O Taiwo
• 金额: $ 15.05万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-09 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10155400
• 关键词: AIDS prevention; Abbreviations; Acquired Immunodeficiency Syndrome; Address; Aging; Area; Behavioral Sciences; Biological; Biostatistics Core; Cardiovascular Diseases; Caring; Chicago; Cities; Clinic; Clinical; Clinical Data; Clinical Informatics; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical assessments; Collaborations; Colorectal; Communities; Computational Technique; Computer Analysis; Conduct Clinical Trials; Data; Development; Diagnosis; Discipline; Disease; Educational Curriculum; Elderly; Electronic Health Record; Endothelium; Epidemic; Foundations; Functional disorder; Funding; Future; Genital; Genitalia; Glossary; Goals; Growth; HIV; HIV Infections; Health; Health system; Human Subject Research; Inflammation; Infrastructure; Institution; Institutional Review Boards; Laboratories; Lesbian Gay Bisexual Transgender Queer; Link; Machine Learning; Mentors; Mission; Monitor; Mucous Membrane; National Heart, Lung, and Blood Institute; Older Population; Outcome; Participant; Patient Outcomes Assessments; Patients; Persons; Population; Predictive Analytics; Process; Program Development; Provider; Public Health; Reporting; Research; Research Personnel; Research Support; Resource Informatics; Resources; Risk; SECTM1 gene; Scientist; Services; Site; Sleep Disorders; Social Sciences; Special Population; Specimen; Study Section; Technology; Tissues; Tonsil; Translational Research; Treatment Effectiveness; United States National Institutes of Health; Universities; Update; Viral; Viral Pathogenesis; Vulnerable Populations; adjudicate; antiretroviral therapy; base; care providers; career development; clinical decision support; clinical phenotype; clinical practice; community organizations; comorbidity; computing resources; cytokine; data warehouse; digital; eHealth; implementation science; improved; indexing; innovation; member; microbiome; operation; pre-exposure prophylaxis; programs; reactive hyperemia; recruit; repository; research study; screening program; service providers; success; tool

PROJECT SUMMARY THIRD COAST CFAR CORE C: CLINICAL SCIENCES CORE (CSC) In 2017, new HIV infections in Chicago decreased somewhat, and 92% of persons diagnosed with HIV were linked to care within 12 months of diagnosis. However, major problems remain. Only 36% of persons living with HIV (PLWH) in 2017 were retained in care, and only 48% achieved viral suppression. In addition, successes of antiretroviral therapy (ART) have led to a rising population of older PLWH, which has made aging-related comorbidities a proximate threat to well-suppressed PLWH and ultimately an increasing public health challenge. Thus, the needs to improve real-world effectiveness of treatments, as well as HIV prevention, continue. The Clinical Sciences Core (CSC) will intensify its support of research that addresses these problems, building on infrastructure and linkages that we have created within and between Northwestern University (NU) and the University of Chicago (UC). An expanding group of community organization partners also increases reach to service providers, now notably including Howard Brown Health (HBH) that has expanded sites to areas of most need and has a long commitment to the health of the LGBTQ community in Chicago. Offering CSC expertise and services across disciplines and institutions is central to our mission and supports the development of new scientific partnerships. This expertise includes human subjects research on streamlining ART and studying aging-associated comorbidities and inflammation. Our accomplished and dynamic Clinical Informatics Group (CIG) will continue advancing researcher access to sophisticated techniques for computation, analyses of Electronic Health Record (EHR)-derived data, and emerging digital tools for research participants. The CSC also emphasizes disseminating research findings and best practices, as well as engaging with community-based clinics and HIV screening programs. The long-term goal of the CSC is to significantly increase the number of outstanding clinical investigators, and the trans-disciplinary resources available to them, in order to fuel discoveries that will propel us towards the end of the HIV epidemic. The CSC’s specific aims to reach this goal are to: 1) support clinical research that interacts with HIV-infected and at-risk participants, and/or obtains and studies clinical data and specimens from them; 2) catalyze and support new research on non-AIDS comorbidities, including clinical phenotyping and pathophysiology of inflammation and accelerated aging in HIV; 3) expand research collaborations and linkages among study participants, clinical HIV researchers, HIV care providers, other implementation partners and trainees. In the next project period, the CSC commits to expanding the scope and impact of research on non-AIDS comorbidities among PLWH on ART as a major contributor to TC CFAR’s Overall aim 2. Each of the CSC specific aims contributes to Overall aim 2 on non-AIDS comorbidities, and the intent is to increase the CSC users’ trans-disciplinary research on aging and comorbidities in HIV.

项目概要 第三海岸 CFAR 核心 C：临床科学核心 (CSC) 2017年，芝加哥新发艾滋病毒感染人数有所下降，92%的艾滋病毒确诊者 然而，只有 36% 的患者仍存在严重问题。 2017 年艾滋病病毒感染者 (PLWH) 被保留在护理中，只有 48% 实现了病毒抑制。 抗逆转录病毒治疗（ART）导致老年感染者数量不断增加，这使得与衰老相关的疾病 合并症对受到良好抑制的艾滋病病毒感染者构成直接威胁，并最终成为日益严峻的公共卫生挑战。 因此，提高现实世界治疗有效性以及艾滋病毒预防的需求仍然存在。 临床科学核心 (CSC) 将加强对解决这些问题的研究的支持 我们在西北大学 (NU) 内部以及之间创建的基础设施和联系 芝加哥大学 (UC) 的社区组织合作伙伴群体不断扩大，也扩大了影响范围。 服务提供商，现在特别包括 Howard Brown Health (HBH)，该公司已将站点扩展到大多数地区 需要并长期致力于芝加哥 LGBTQ 社区的健康，提供 CSC 专业知识。 跨学科和机构的服务是我们使命的核心，并支持新的开发 这种专业知识包括关于简化 ART 和学习的人类受试者研究。 与衰老相关的合并症和炎症。我们经验丰富且充满活力的临床信息学小组。 (CIG) 将继续推动研究人员获得复杂的计算、分析技术 CSC 还提供来自电子健康记录 (EHR) 的数据以及新兴的数字工具。 强调传播研究成果和最佳实践，以及与社区合作 CSC 的长期目标是显着增加诊所和艾滋病毒筛查项目的数量。 优秀的临床研究人员以及他们可用的跨学科资源，以推动 这些发现将推动我们终结艾滋病毒流行。CSC 的具体目标是实现这一目标。 是为了： 1) 支持与 HIV 感染者和高危参与者相互作用的临床研究，和/或获得和 2）促进和支持非艾滋病的新研究 合并症，包括艾滋病毒炎症的临床表型和病理生理学以及加速衰老； 3) 扩大研究参与者、临床艾滋病毒研究人员、艾滋病毒护理之间的研究合作和联系 在下一个项目期间，CSC 承诺扩大规模。 艾滋病病毒感染者非艾滋病合并症的研究范围和影响对抗逆转录病毒治疗的主要贡献者 TC CFAR 的总体目标 2。每个 CSC 具体目标都有助于实现关于非艾滋病合并症的总体目标 2， 其目的是增加 CSC 用户对衰老和艾滋病毒合并症的跨学科研究。