Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria

扩大多学科神经艾滋病研究培训以改善尼日利亚的艾滋病毒治疗结果

• 批准号: 10462158
• 负责人: Babafemi O Taiwo
• 金额: $ 7.71万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-05 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10462158
• 关键词: Address; Africa; Assessment tool; Biological; Brain Diseases; Cerebrovascular Disorders; Clinical; Clinical Research; Clinical Sciences; Communicable Diseases; Communities; Consequences of HIV; Discipline; Disclosure; Doctor of Philosophy; Drug resistance; Extramural Activities; Fellowship; Funding; Genomics; HIV; Healthcare Systems; Impairment; Infrastructure; Knowledge; Lead; Manuscripts; Master of Science; Measurement; Mental Depression; Mental Health; Mental disorders; Mentors; Neurocognitive; Neurologic; Neurologist; Neurology; Neuropsychology; Nigeria; Nigerian; Observational Study; Outcome; Pharmacology; Physicians; Psyche structure; Psychiatric Nursing; Psychiatrist; Psychologist; Quality of life; Research; Research Personnel; Research Support; Research Training; Residual state; Shoulder; Standardization; Substance abuse problem; Time; Toxic effect; Training; Translational Research; Universities; Writing; clinical investigation; co-infection; collaboratory; implementation science; improved; laboratory experience; medical specialties; multidisciplinary; neuroAIDS; neurobehavioral; optimal treatments; post-doctoral training; programs; radiologist; social stigma

Nigeria has a high burden of HIV-related brain disorders (NeuroAIDS), including mental health disorders and neurocognitive or neurological impairment. Over the last 4 years, the Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria (D43TW009608-03) has developed three NeuroAIDS research cores with 10 investigators, two observational studies, and trained research support staff, including 3 psychometricians at the University of Ibadan (UI). Reviewing our progress with our Nigerian partners, we have identified residual gaps, which we propose to address by doubling the number of investigators and psychometricians through the Expanded Multidisciplinary NeuroAIDS Research Training to Improve HIV Outcomes in Nigeria. In the Mental Health Core, we will: 1) add implementation science by providing PhD training to a physician who excelled in the Northwestern University Master of Science in Clinical Investigation (MSCI) program, and 2) provide focused didactics and mentored research for 3 clinical psychologists/mental health nurses, thus expand UI's community of NeuroAIDS researchers to include these disciplines that are currently unrepresented but are key components of Nigeria's mental healthcare system. In the Translational and Clinical Sciences Core, we will provide intensive laboratory training for a pharmacology PhD candidate, postdoctoral training to a virologist, MSCI to a neurology/infectious diseases physician, and specialty clinical research training to a radiologist, all with integrated mentored research. In the Neuropsychological Infrastructure Core, we will provide postdoctoral neuropsychology fellowships for psychiatrists or neurologists to produce two experts who will train new psychometricians, as well as lead already-trained psychometricians and biostatisticians to create transformative capacity for neuropsychological assessment and analytics locally. Over half of each trainee's time will be in UI. The aggregated capacity of the cores will build into a research program equipped to lead in: 1) Mental Health Research- e.g., depression, stigma, disclosure, quality of life and, substance abuse; and 2) Translational and Clinical Research- e.g. understanding the biologic basis and optimal treatment of HAND; and unraveling the contribution of CNS compartmentalization, ART toxicity, drug resistance, cerebrovascular diseases, genomics, and co-infections to NeuroAIDS. The program will be distinguished by neuropsychological assessment expertise and locally standardized assessment instruments with appropriate norms to provide reliable and valid measurement of neurobehavioral consequences of HIV and its treatments in Nigeria. Training will be expanded further, knowledge disseminated, and ideas cross- fertilized through forums that we created in UI, including a monthly NeuroAIDS Collaboratory and a biannual NeuroAIDS Week with about 150 attendees/year. Manuscript writing and grantsmanship mentoring will prepare the trainees to become funded independent investigators. In 5 years, UI's multidisciplinary researchers will shoulder NeuroAIDS research in Nigeria with extramural funding, impacting the whole of Africa.

尼日利亚的艾滋病毒相关脑部疾病（神经艾滋病）负担很重，包括精神健康障碍和 神经认知或神经功能障碍。在过去 4 年里，多学科神经艾滋病研究 尼日利亚改善艾滋病毒结果的培训 (D43TW009608-03) 已开展三项 NeuroAIDS 研究 由 10 名研究人员、两项观察性研究和训练有素的研究支持人员（包括 3 名研究人员）组成的核心 伊巴丹大学（UI）的心理测量学家。回顾我们与尼日利亚合作伙伴取得的进展，我们发现 查明了剩余的差距，我们建议通过将调查人员的数量增加一倍来解决这一问题 心理测量学家通过扩展多学科神经艾滋病研究培训来改善艾滋病毒 尼日利亚的成果。在心理健康核心中，我们将：1）通过提供博士学位来增加实施科学 培训一位在西北大学临床研究理学硕士中表现出色的医生 (MSCI) 计划，以及 2) 为 3 名临床心理学家/心理医生提供重点教学和指导研究 健康护士，从而扩大伊利诺伊大学神经艾滋病研究人员社区，将这些学科包括在内 目前无人参与，但却是尼日利亚精神卫生保健系统的关键组成部分。在翻译中 和临床科学核心，我们将为药理学博士候选人提供强化实验室培训， 病毒学家的博士后培训、神经病学/传染病医生的 MSCI 培训以及专业临床培训 对放射科医生进行研究培训，所有这些都包含综合指导研究。在神经心理学方面 基础设施核心，我们将为精神病学家或神经科医生提供博士后神经心理学奖学金 培养两名专家来培训新的心理测量师，并领导已经接受过培训的心理测量师 和生物统计学家在当地建立神经心理学评估和分析的变革能力。 每个学员一半以上的时间都花在 UI 上。核心的聚合能力将构建成一项研究 计划旨在引导：1) 心理健康研究——例如抑郁、耻辱、披露、生活质量 以及药物滥用； 2) 转化和临床研究 - 例如了解生物学基础并 HAND 的最佳治疗；并揭示中枢神经系统区室化、ART 毒性、药物的贡献 耐药性、脑血管疾病、基因组学和神经艾滋病的合并感染。该计划将是 以神经心理学评估专业知识和本地标准化评估工具而著称 制定适当的规范，为 HIV 的神经行为后果提供可靠且有效的测量 及其在尼日利亚的治疗方法。将进一步扩大培训、传播知识、交流思想 通过我们在 UI 中创建的论坛，包括每月一次的 NeuroAIDS Collaboratory 和每两年一次的论坛 NeuroAIDS 周，每年约有 150 名参与者。手稿写作和资助指导将准备 受训者成为受资助的独立调查员。五年内，伊利诺伊大学的多学科研究人员将 利用外部资金承担尼日利亚的神经艾滋病研究，影响整个非洲。