Maintenance of an SPF Macaque Breeding Colony for AIDS Research

维持 SPF 猕猴繁殖群以进行艾滋病研究

• 批准号: 10549735
• 负责人: KASI E RUSSELL-LODRIGUE
• 金额: $ 141.58万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-09 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10549735
• 关键词: 2019-nCoV; Acquired Immunodeficiency Syndrome; Address; Animals; Award; Behavioral; Breeding; Caring; Clinical; Communities; Country; Development; Emerging Communicable Diseases; Ensure; Funding; Funding Opportunities; Genetic; Goals; Grant; Growth; HIV/AIDS; Human Resources; Income; Individual; Infectious Agent; Infrastructure; Investigation; Investments; Leadership; Macaca; Macaca mulatta; Maintenance; Measles virus; Medical; Monitor; Opportunistic Infections; Pathology; Population; Population Genetics; Population Sizes; Primates; Production; Program Description; Research; Research Personnel; Research Project Grants; Resources; Sales; Specific qualifier value; Techniques; Testing; Time; Trypanosoma cruzi; United States; United States National Institutes of Health; Viral; Virus; Wages; Writing; base; congenital infection; demographics; experience; genetic analysis; genetic testing; germ free condition; improved; nonhuman primate; offspring; programs; repaired; success; vaccine development

Project Summary/Abstract - Overall The Tulane National Primate Research Center (TNPRC) has one of the largest rhesus monkey breeding colonies in the United States. The objective of this application is to request funds for continued support and maintenance of the U42 supported SPF Indian-origin rhesus monkey breeding colony at the TNPRC. Production will be moderately increased in the next few years based on recent developments in funding and animal demand. The specific aims address the components specified in the funding opportunity announcement (FOA) and are divided into the Overall program description, Husbandry and Management Core, Viral Testing Core, and MHC Genetic Typing Core. Program income and TNPRC funds will be used to support components of the program not covered by grant funds including: per diem for any colony animals in excess of the animals supported by this application, additional testing required for those animals, infrastructure repairs and improvements, veterinary clinical and pathology support, behavioral management support, and portions of the genetic testing. Specific Aims: Overall. To maintain the existing SPF colony and distribute available animals to the NIH funded HIV/AIDS research community. Husbandry and Management Core. To provide husbandry and veterinary care for the SPF breeding colony established in the existing U42 grant. This includes a robust program for clinical veterinary medical care and behavioral management. The colony has reached a mature self-sustaining status with ideal demographics to produce up to 150 animals available for assignment each year. Program income generated by the animal sales will be returned to an account for use in supporting the aims of the grant. Viral Testing Core. To assure the SPF status of the colony through continued viral testing of existing breeding colony animals and all offspring. Continue to expand characterization of the colony beyond the required 4 viruses to include agents such as measles virus, SARS CoV2, Trypanosoma cruzi, and other emerging infectious diseases that threaten nonhuman primates. MHC Genetic Typing Core. To continue genetic analysis and MHC typing of the colony and provide expanded genetic characterization through enhanced techniques.

项目总结/摘要 - 总体 杜兰国家灵长类动物研究中心 (TNPRC) 拥有最大的恒河猴繁殖群之一 在美国。此应用程序的目的是请求资金以继续支持和维护 U42 支持 TNPRC 的 SPF 印度原产恒河猴繁殖群。产量将 根据资金和动物需求的最新发展，未来几年将适度增加。这 具体目标涉及融资机会公告 (FOA) 中指定的组成部分，并分为 分为总体计划描述、畜牧和管理核心、病毒检测核心和 MHC 遗传 打字核心。计划收入和 TNPRC 资金将用于支持未涵盖的计划组成部分 通过赠款资金，包括：超出本申请支持的动物的任何群体动物的每日津贴， 这些动物需要进行额外的测试、基础设施维修和改进、兽医临床和 病理学支持、行为管理支持和部分基因测试。 具体目标： 全面的。维持现有的 SPF 群体并将可用的动物分配给 NIH 资助的艾滋病毒/艾滋病 研究社区。 畜牧和管理核心。为 SPF 繁殖群提供畜牧和兽医护理 在现有的 U42 拨款中设立。这包括一个强有力的临床兽医医疗保健计划和 行为管理。该殖民地已达到成熟的自给自足状态，拥有理想的人口结构 每年生产多达 150 只可供分配的动物。动物销售产生的计划收入 将返回到一个帐户，用于支持赠款的目的。 病毒检测核心。通过对现有育种进行持续病毒测试，确保群体的 SPF 状态 群体动物和所有后代。继续扩大菌落特征，超出所需的 4 种病毒 包括麻疹病毒、SARS CoV2、克氏锥虫和其他新出现的传染病 威胁非人类灵长类动物的疾病。 MHC 基因分型核心。继续对菌落进行遗传分析和 MHC 分型，并提供扩展的 通过增强技术进行遗传表征。