Sheltered Outdoor Housing Expansion for the TNPRC SPF Rhesus Macaque Breeding Colony

TNPRC SPF 恒河猴繁殖地的庇护室外房屋扩建

• 批准号: 10588719
• 负责人: KASI E RUSSELL-LODRIGUE
• 金额: $ 649.98万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588719
• 关键词: Address; Animal Experimentation; Animals; Applied Research; Area; Basic Science; Biomedical Research; Breeding; Censuses; Complement; Ensure; Evaluation; Faculty; Funding; Future; Health; Housing; Human; Infrastructure; Institution; Knowledge; Macaca; Macaca mulatta; Personal Satisfaction; Primates; Production; Recommendation; Reporting; Research; Research Personnel; Research Priority; Resources; Scientific Advances and Accomplishments; United States National Institutes of Health; Universities; Weather; design; flexibility; germ free condition; improved; nonhuman primate; novel; operation; programs

PROJECT SUMMARY / ABSTRACT The Tulane National Primate Research Center (TNPRC) of Tulane University is one of seven National Primate Research Centers (NPRC) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and well-being. The NPRC program provides resources and opportunities for research using nonhuman primates (NHP) to core faculty and faculty affiliated with outside institutions. The TNPRC specific pathogen free (SPF) rhesus macaque breeding colony is among the largest in the NPRC program, with a census of approximately 5,000. Over the past 5 years, the TNPRC SPF breeding colonies have supplied 2,099 animals for research programs of core and affiliate investigators across the US. There continues to be high national demand for SPF rhesus macaques which cannot be met by current NPRC breeding operations. In 2018, the NIH sponsored the NHP Evaluation and Analysis Project to enhance understanding of the demand for and supply of NHP within the US. Key recommendations made to ensure the adequate supply of NHPs for biomedical research included improving infrastructure and providing support for SPF NHP breeding colony expansion. Since the results of the 2018 report were made public, the TNPRC has undertaken assessments to identify the needs of the program to expand its SPF rhesus macaque breeding colony. Along with funding from the NIH, the TNPRC has committed funds and initiated projects to: 1) improve the breeding colony management program and 2) expand infrastructure to meet the current and projected future national demand. Principal components of the long-term plan for infrastructure improvement are to increase the number of indoor/outdoor housing configurations for added protection of NHP from inclement weather and complement the existing outdoor NHP housing enclosures. Funding is requested to construct indoor/outdoor enclosures located on the breeding colony campus for the purpose of housing and breeding SPF rhesus macaques. This project will add facilities to support our commitment to expand production of SPF rhesus macaques used for NIH-established priority research areas at the TNPRC and nationally. The facilities have been designed in alignment with our long-term infrastructure improvement plan to enhance protection of animals, increase housing capacity and flexibility, and provide novel and proven environmental enhancement components. The animals produced as a result of this infrastructure improvement project will help address the national shortage of SPF macaques.

项目概要/摘要 杜兰大学杜兰国家灵长类动物研究中心 (TNPRC) 是七个国家灵长类动物研究中心之一 研究中心 (NPRC) 由美国国立卫生研究院资助。该中心致力于提供 基础设施和对基础和应用研究工作的支持，以推进科学知识和提高 人类和动物的健康和福祉。 NPRC 计划提供研究资源和机会 使用非人类灵长类动物（NHP）作为核心教师和附属于外部机构的教师。国家核研究委员会 无特定病原体 (SPF) 恒河猴繁殖群体是 NPRC 计划中最大的群体之一， 人口普查大约有 5,000 人。在过去 5 年里，TNPRC SPF 繁殖群已提供 2,099 只 用于美国各地核心和附属研究人员的研究项目的动物。仍有持续高位 国家对 SPF 恒河猴的需求，目前的 NPRC 育种业务无法满足。 2018年， NIH 赞助了 NHP 评估和分析项目，以加强对需求的了解和 美国境内 NHP 的供应。为确保生物医学领域 NHP 的充足供应而提出的关键建议 研究包括改善基础设施和为 SPF NHP 繁殖群体扩张提供支持。自从 2018年报告结果公布后，TNPRC已进行评估以确定需求 扩大 SPF 恒河猴繁殖群计划。除了 NIH 的资助外，TNPRC 已承诺资金并启动项目以：1) 改进繁殖群体管理计划以及 2) 扩大基础设施以满足当前和预计未来的国家需求。主要组成部分 基础设施改善的长期计划是增加室内/室外住房的数量 增强 NHP 免受恶劣天气影响的配置，并补充现有的室外 NHP 外壳。需要资金建造位于繁殖地的室内/室外围栏 校园的目的是饲养和繁殖 SPF 恒河猴。本项目将增设配套设施 我们致力于扩大用于 NIH 确定的优先研究领域的 SPF 恒河猴的生产 在 TNPRC 和全国范围内。这些设施的设计符合我们的长期基础设施 改善计划，加强对动物的保护，增加住房容量和灵活性，并提供新颖的 和经过验证的环境增强组件。由于该基础设施而产生的动物 改良项目将有助于解决全国SPF猕猴短缺问题。