Sheltered Outdoor Housing Expansion for the TNPRC SPF Rhesus Macaque Breeding Colony

TNPRC SPF 恒河猴繁殖地的庇护室外房屋扩建

• 批准号: 10588719
• 负责人: KASI E RUSSELL-LODRIGUE
• 金额: $ 649.98万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588719
• 关键词: Address; Animal Experimentation; Animals; Applied Research; Area; Basic Science; Biomedical Research; Breeding; Censuses; Complement; Ensure; Evaluation; Faculty; Funding; Future; Health; Housing; Human; Infrastructure; Institution; Knowledge; Macaca; Macaca mulatta; Personal Satisfaction; Primates; Production; Recommendation; Reporting; Research; Research Personnel; Research Priority; Resources; Scientific Advances and Accomplishments; United States National Institutes of Health; Universities; Weather; design; flexibility; germ free condition; improved; nonhuman primate; novel; operation; programs

PROJECT SUMMARY / ABSTRACT The Tulane National Primate Research Center (TNPRC) of Tulane University is one of seven National Primate Research Centers (NPRC) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and well-being. The NPRC program provides resources and opportunities for research using nonhuman primates (NHP) to core faculty and faculty affiliated with outside institutions. The TNPRC specific pathogen free (SPF) rhesus macaque breeding colony is among the largest in the NPRC program, with a census of approximately 5,000. Over the past 5 years, the TNPRC SPF breeding colonies have supplied 2,099 animals for research programs of core and affiliate investigators across the US. There continues to be high national demand for SPF rhesus macaques which cannot be met by current NPRC breeding operations. In 2018, the NIH sponsored the NHP Evaluation and Analysis Project to enhance understanding of the demand for and supply of NHP within the US. Key recommendations made to ensure the adequate supply of NHPs for biomedical research included improving infrastructure and providing support for SPF NHP breeding colony expansion. Since the results of the 2018 report were made public, the TNPRC has undertaken assessments to identify the needs of the program to expand its SPF rhesus macaque breeding colony. Along with funding from the NIH, the TNPRC has committed funds and initiated projects to: 1) improve the breeding colony management program and 2) expand infrastructure to meet the current and projected future national demand. Principal components of the long-term plan for infrastructure improvement are to increase the number of indoor/outdoor housing configurations for added protection of NHP from inclement weather and complement the existing outdoor NHP housing enclosures. Funding is requested to construct indoor/outdoor enclosures located on the breeding colony campus for the purpose of housing and breeding SPF rhesus macaques. This project will add facilities to support our commitment to expand production of SPF rhesus macaques used for NIH-established priority research areas at the TNPRC and nationally. The facilities have been designed in alignment with our long-term infrastructure improvement plan to enhance protection of animals, increase housing capacity and flexibility, and provide novel and proven environmental enhancement components. The animals produced as a result of this infrastructure improvement project will help address the national shortage of SPF macaques.

项目摘要 /摘要 杜兰大学的杜兰国家灵长类动物研究中心（TNPRC）是七个国家灵长类动物之一 由美国国立卫生研究院赞助的研究中心（NPRC）。该中心致力于提供 基础架构和支持基础和应用研究工作，以提高科学知识并改善 人类和动物的健康和福祉。 NPRC计划为研究提供了资源和机会 使用非人类灵长类动物（NHP）与外部机构相关的核心教师和教师。 TNPRC 特定的无病原体（SPF）恒河猕猴繁殖菌落是NPRC计划中最大的，其中包括 大约5,000的人口普查。在过去的5年中，TNPRC SPF繁殖菌落提供了2,099 核心研究计划的动物和分支机构研究人员的动物。继续很高 国家对SPF恒河猕猴的需求无法通过当前的NPRC育种操作来满足。在2018年， NIH赞助了NHP评估和分析项目，以增强对对和的需求的理解 美国境内的NHP供应。提出的关键建议是确保NHP足够的生物医学供应 研究包括改善基础设施并为SPF NHP繁殖菌落扩张提供支持。自从 2018年报告的结果公开了，TNPRC进行了评估以确定需求 扩大其SPF恒河猕猴繁殖殖民地的计划。以及来自NIH的资金，TNPRC 已投入资金并启动项目：1）改善繁殖殖民地管理计划和2） 扩大基础设施，以满足当前和预计的未来国家需求。主要组成部分 基础设施改进的长期计划是增加室内/室外住房的数量 为NHP添加保护免受恶劣天气的配置，并补充现有的室外NHP 住房外壳。要求资金建造位于繁殖殖民地上的室内/室外外壳 校园是出于住房和繁殖SPF恒河猕猴的目的。该项目将增加支持的设施 我们致力于扩大用于NIH建立优先研究领域的SPF恒河猕猴生产的承诺 在TNPRC和全国。该设施的设计与我们的长期基础设施保持一致 改进计划以增强动物保护，提高住房能力和灵活性并提供新颖 并经过验证的环境增强组件。由于这种基础设施而产生的动物 改进项目将有助于解决全国范围内SPF猕猴的短缺。