The Role of Food Insecurity and Sensitization in Excess Weight Gain in Adolescents from Low to Moderate Income Households

粮食不安全和敏感性在低收入和中等收入家庭青少年体重过度增加中的作用

• 批准号: 10533813
• 负责人: Jennifer L Temple
• 金额: $ 68.26万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-15 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10533813
• 关键词: 3-Dimensional; Adolescent; Adult; Behavioral; Body Weight; Body Weight Changes; Body mass index; Cardiovascular system; Caregivers; Child; Chronic Disease; Communities; Complex; Consumption; Data; Development; Eating; Education; Effectiveness; Energy Intake; Enrollment; Environmental Risk Factor; Ethnic Origin; Etiology; Family dynamics; Food; Food Access; Goals; Healthy Eating; Home; Household; Income; Individual; Intake; Intervention; Longevity; Low income; Mediating; Neighborhoods; Nutritional; Obesity; Occupations; Overweight; Parents; Perception; Periodicals; Phenotype; Play; Population; Prevention strategy; Public Health; Race; Reporting; Research; Role; Sampling; Secure; Self Efficacy; Socioeconomic Status; Testing; Time; Weight; Weight Gain; Work; behavioral phenotyping; behavioral study; cohort; discounting; disorder risk; energy density; ethnic minority population; evidence base; excessive weight gain; experience; feeding; food environment; food insecurity; food resource; food security; high risk; high risk population; individualized medicine; lower income families; member; novel; obesity prevention; parental influence; perceived stress; prospective; racial minority population; social; social determinants; social health determinants; treatment strategy

Abstract: The etiology of obesity is complex and is driven by different factors in different populations, including across developmental stages, in different racial and ethnic communities, and at different levels of socioeconomic status (SES). It is important to identify the factors that promote excess energy intake in the highest risk populations to develop evidence-based, effective obesity prevention and treatment strategies. Over the past decade, it has become apparent that studying behavioral phenotypes that predict overweight, obesity, and weight change across the lifespan is critical for developing individualized intervention strategies with a high degree of efficacy and effectiveness. One novel phenotype that has been identified and characterized is sensitization of the relative reinforcing value (RRV) of food. This is defined as an increase in the RRV of a food after repeated, daily consumption of high energy density (HED) food for two weeks. In adults, sensitization is positively associated with BMI and prospectively predicts weight gain over time. The cross-sectional relationship between zBMI and sensitization has been replicated in a cohort of adolescents enrolled in the UBSNAK study and recent data have shown that, as in adults, sensitization prospectively predicts zBMI change in adolescents. It is also known, from preliminary work, that the relationship between food insecurity and zBMI is associated with other individual, behavioral, and environmental factors, such as delay discounting, perceived stress, and self-efficacy for healthy eating. The goals of the proposed study are 1) to investigate the relationship between food insecurity and sensitization 2) to determine the role of sensitization in determining zBMI and zBMI change in a population of moderate to low-income adolescents and 3) to determine how adolescent food insecurity interacts with household food insecurity to moderate the relationship between sensitization and zBMI change. The first aim will test the hypothesis that food insecurity is related to sensitization and that this relationship is mediated by individual, behavioral, and environmental factors. The second aim will test the hypothesis that household food insecurity moderates the relationship between sensitization and zBMI change over time in adolescents. The third aim will test the hypothesis that adolescent food insecurity interacts with household food insecurity to moderate the relationship between sensitization and zBMI change and that one factor that impacts this relationship is adolescent eating autonomy. When taken together, this study will help to identify and characterize novel intervention targets in a population of adolescents at higher risk for overweight and obesity.

摘要：肥胖症的病因很复杂，并由不同人群的不同因素驱动， 包括跨发展阶段，不同的种族和族裔社区以及不同级别的 社会经济地位（SES）。重要的是确定促进过多能量摄入的因素 开发基于证据的有效肥胖预防和治疗策略的最高风险人群。 在过去的十年中，很明显，研究预测超重的行为表型 肥胖和整个寿命的体重变化对于制定个性化干预策略至关重要 具有高度的功效和有效性。已鉴定出来的一种新型表型 特征是食物的相对增强值（RRV）的敏化。这被定义为增加 每天每天消耗高能量密度（HED）食物两周后，食物的RRV。在 成年人的敏化与BMI呈正相关，并前瞻性地预测体重随着时间的流逝而增加。这 ZBMI与致敏之间的横断面关系已在一群青少年中复制 参加瑞银研究和最新数据表明，与成人一样，前瞻性敏化 预测青少年的ZBMI变化。从初步工作中也知道 粮食不安全和ZBMI与其他个人，行为和环境因素有关，例如 延迟折现，感知压力和健康饮食的自我效能。拟议的研究的目标是 1）研究粮食不安全和致敏之间的关系2）确定 在确定ZBMI和ZBMI变化中的敏感性中等至低收入青少年 3）确定青少年粮食不安全感如何与家庭粮食不安全相互作用以调节 致敏与ZBMI变化之间的关系。第一个目的将检验粮食不安全感的假设 与敏化有关，这种关系是由个人，行为和环境介导的 因素。第二个目标将检验家庭粮食不安全性的假设调节关系 在敏化和ZBMI之间随着时间的推移而变化。第三个目标将检验以下假设 青少年粮食不安全感与家庭粮食不安全相互作用，以减轻 敏化和ZBMI的变化以及影响这种关系的一个因素是青少年饮食 自治。合在一起时，这项研究将有助于识别和表征一个新的干预目标 超重和肥胖风险较高的青少年人口。