Gender Differences in Responses to Caffeine in Children and Adolescents

儿童和青少年对咖啡因反应的性别差异

• 批准号: 8433413
• 负责人: Jennifer L Temple
• 金额: $ 30.34万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433413
• 关键词: 17 year old; Acute; Adolescent; Adult; Alleles; Behavioral; Caffeine; Child; Data; Development; Dose; Double-Blind Method; Drug abuse; Drug usage; Energy Intake; Estradiol; Funding; Gender; Genes; Genetic Polymorphism; Genotype; Illicit Drugs; Individual; Laboratories; Laboratory Study; Luteal Phase; Maintenance; Male Adolescents; Measures; Mediating; Menstrual cycle; Moods; National Institute of Drug Abuse; Neural Pathways; Pharmaceutical Preparations; Phase; Physiological; Placebo Control; Play; Property; Puberty; Purinergic P1 Receptors; Research; Role; Series; Sex Characteristics; Staging; Testing; Time; Time Study; Work; boys; design; drug of abuse; girls; high risk; improved; proliferative phase Menstrual cycle; research study; response; steroid hormone

DESCRIPTION (provided by applicant): Caffeine is the most widely used psychoactive substance in the world and its use is increasing among children. Although considered safe, the majority of empirical data on the effects of caffeine have been collected in adults. Our previous studies, supported by a KO1 from NIDA, have demonstrated that caffeine has dose-dependent effects on physiological, mood, and energy intake in adolescents and that boys appear to be more sensitive to the effects of caffeine than girls. The following proposal describes a series of laboratory studies aimed at investigating the mechanisms underlying these gender differences, including pubertal development, steroid hormone concentrations, menstrual cycle phase, and adenosine receptor genotypes. These studies are important because they will provide much needed information on the effects of caffeine in children and adolescents as well as identify mechanisms that influence gender differences in response to caffeine and, perhaps, other drugs of abuse.

描述（由申请人提供）：咖啡因是世界上使用最广泛的精神活性物质，儿童的使用正在增加。尽管被认为是安全的，但大多数关于咖啡因作用的经验数据已在成年人中收集。我们以前的研究在NIDA的KO1支持下，表明咖啡因对青少年的生理，情绪和能量摄入剂具有剂量依赖性作用，并且男孩似乎对咖啡因的影响比女孩更敏感。以下建议描述了一系列旨在研究这些性别差异的机制，包括青春期发育，类固醇激素浓度，月经周期阶段和腺苷受体基因型。这些研究很重要，因为它们将提供有关咖啡因对儿童和青少年影响的急需信息，并确定影响咖啡因以及其他滥用药物的性别差异的机制。