Conversion of Bryan Cagewash Area to Rodent Housing Space

将布莱恩笼洗区域改造成啮齿动物居住空间

• 批准号: 10531763
• 负责人: JOHN N. NORTON
• 金额: $ 38.32万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10531763
• 关键词: Acoustics; Aging; Animal Housing; Animals; Area; Basic Science; Biomedical Engineering; Censuses; Collaborations; Containment; Derivation procedure; Direct Costs; Elements; Ensure; Environmental Monitoring; Equipment; Floor; Funding; Future; Grant; Growth; Health; Housing; Human; Image; Individual; Institution; Investments; Laboratories; Laboratory Animal Production and Facilities; Laboratory Animals; Location; Longitudinal Studies; Medical; Microscopy; Modeling; Modernization; Mus; Neurobiology; Outcome; Performance; Procedures; Quarantine; Rattus; Research; Research Personnel; Research Project Grants; Rodent; Security; Site; Structure; System; Translational Research; Translations; United States National Institutes of Health; Universities; Update; Water; Work; aged; animal care; animal facility; animal resource; cost estimate; design; equipment acquisition; imaging modality; improved; in vivo; instrumentation; light intensity; medical schools; meetings; operation; preclinical study; programs; recruit; square foot; success; translational study; ventilation

Duke University is committed to scientific research and its translation to improve human health, which includes appropriate use of animals in research. In 2019, Duke completed an updated Master Plan for Duke’s animal program showing insufficient rodent space for existing researchers and future recruits using conservative census growth projections. In FY2020, Duke researchers required significant use of rodent species and were responsible for over $109 million in annual direct costs from the National Institutes of Health for research using rodents. The strength of Duke’s research programs with rodents is projected at the continued growth of 7% annually. Importantly, current demand already exceeds capacity. As an element of Duke’s updated Master Plan to expand housing space for rodents to meet current and projected research needs and to enable repurposing vacated space, renovation of a cagewash facility along with providing caging and ancillary items to equip 614 net square feet (nsf) located in the shared-use Bryan Research Animal Facility (BRAF) is planned. This proposal leverages ongoing, institutionally funded work to relocate and update Duke’s existing cagewash facilities for rodents to an off-site location (opening in 2022 with automated, energy-efficient equipment), allowing this proposal to focus on renovation of a vacated cagewash space in an on-campus vivarium to meet growing research efforts of the Departments of Neurobiology and Biomedical Engineering (BME) as well as the Center of In-Vivo Microscopy (CIVM). Specifically, we propose purchasing of individually ventilated cages (IVC) to expand mouse housing in the shared-use BRAF, which is uniquely and efficiently operated to support independent and collaborative research using rodents. The BRAF is a modern vivarium integral to the success of its users’ research objectives, is ideally located for collaborations, and is unique in permitting longitudinal studies of rodents, particularly when animals need to be returned to their housing location after being taken to imaging areas and researcher laboratories containing specialized instrumentation critical to their research objectives. In addition, this facility supports the ability of the CIVM, Neurobiology and BME researchers to conduct studies with rodents from other institutions without having to undergo re-derivation or an extensive quarantine period. The BRAF is an essential animal facility in Duke’s research program and needs additional rodent housing for current and future researchers. As this renovation is within an existing centrally managed vivarium, the operation and oversight of the space will be incorporated seamlessly into the veterinary medical, animal care, and administrative structure of Duke’s Division of Laboratory Animal Resources (DLAR). The proposed project will leverage institutional investments to increase rodent housing capacity and provide state-of-the-art space for basic, translational, and pre-clinical studies with rodents. In keeping with Duke’s commitment to sustainability, the renovation of vacated space in the shared-use BRAF will meet the requirements of Duke’s High-Performance Building framework.

杜克大学致力于科学研究及其翻译，以改善人类健康，其中包括 适当使用动物在研究中。 2019年，杜克大学完成了杜克动物的最新总体规划 节目显示现有研究人员的啮齿动物空间不足，并使用保守派的未来招募 人口普查增长计划。在2020财年，杜克大学的研究人员需要大量使用啮齿动物，并且 负责使用美国国立卫生研究院的年度直接费用超过1.09亿美元 啮齿动物。杜克大学研究计划与啮齿动物的实力预计将以7％的持续增长为7％ 重要的是。重要的是，当前需求已经超过容量。作为杜克大学更新主的元素 计划扩大啮齿动物的住房空间，以满足当前和预计的研究需求并启用 重新利用空置的空间，改革笼子设施以及提供笼子和 装备位于共享的Bryan Research Animal中的614净平方英尺（NSF）的辅助物品 计划设施（BRAF）。该提案利用正在进行的机构资助的工作来搬迁和 将杜克大学现有的啮齿动物的现有Cagewash设施更新到异地（2022年开放，自动化， 节能设备），允许该提案专注于装修空缺的笼子空间 校园内的校园，以满足神经生物学和生物医学部门不断增长的研究工作 工程（BME）以及体内显微镜（CIVM）的中心。具体来说，我们建议 购买单独通风的笼子（IVC）以在共享的BRAF中扩展鼠标， 它是独特而有效的，以支持独立和协作研究 啮齿动物。 BRAF是其用户研究目标成功不可或缺的现代化的Vivarium，理想情况下是 适合合作，并且在允许啮齿动物的纵向研究方面是独一无二的，尤其是在动物 被带到成像区域和研究人员实验室后，需要返回其住房位置 包含对其研究目标至关重要的专业仪器。此外，此设施支持 CIVM，神经生物学和BME研究人员的能力与其他机构的啮齿动物进行研究 不必经历重新启动或大量隔离期。 BRAF是必不可少的动物 杜克大学研究计划中的设施，需要额外的啮齿动物住房，以供当前和未来的研究人员使用。作为 这项改革位于现有的中央管理的Vivarium范围内，该空间的运营和监督将会 将无缝纳入杜克大学的兽医医疗，动物护理和行政结构 实验室动物资源（DLAR）部。拟议的项目将利用机构投资 提高啮齿动物的住房能力并为基本，翻译和临床前的最新空间 啮齿动物的研究。符合杜克对可持续性的承诺，对空间的改革 共享的BRAF将满足杜克大学高性能建筑框架的要求。