Using epigenetic science to improve environmental health literacy

利用表观遗传学提高环境健康素养

基本信息

批准号：
10524680
负责人：
Michael Rountree
金额：
$ 64.97万
依托单位：
NZUMBE EPIGENETICS
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10524680
关键词：
Active Learning Affect Air American Architecture Award Basic Science Behavior Biological Models Biology Brain Breathing Businesses Chemicals Collaborations Communities Computer software Consumption Custom Decision Making Development Disease Disease susceptibility Eating Education Educational process of instructing Endowment Environment Environmental Exposure Environmental Health Epigenetic Process Equipment Financial Support Folic Acid Gene Expression Regulation Genes Goals Grant Growth Habits Health Health Professional Home Human Human Development Institution Knowledge Laboratories Language Learning Learning Module Life Style Link Marketing Measures National Institute of Environmental Health Sciences Neurospora Neurospora crassa Oregon Organism Outcome Persons Phase Phenotype Play Policy Maker Pollution Population Pregnancy Process Public Health Reporting Risk Role Safety Schools Science Scientist Shapes Small Business Innovation Research Grant Social Interaction Statutes and Laws Stress Structure Students Testing Time Translations Universities Vertebral column Visual Visualization Work college cost education cost epigenetic regulation epigenome experience experimental study falls fetal fictional works fungus genetic makeup grasp hands-on learning health disparity health literacy high school human disease improved in silico innovation junior high school learning outcome man member model organism novel offspring online delivery response risk mitigation success tool undergraduate student web based software

Active Learning Affect Air American Architecture Award Basic Science Behavior Biological Models Biology Brain Breathing Businesses Chemicals Collaborations Communities Computer software Consumption Custom Decision Making Development Disease Disease susceptibility Eating Education Educational process of instructing Endowment Environment Environmental Exposure Environmental Health Epigenetic Process Equipment Financial Support Folic Acid Gene Expression Regulation Genes Goals Grant Growth Habits Health Health Professional Home Human Human Development Institution Knowledge Laboratories Language Learning Learning Module Life Style Link Marketing Measures National Institute of Environmental Health Sciences Neurospora Neurospora crassa Oregon Organism Outcome Persons Phase Phenotype Play Policy Maker Pollution Population Pregnancy Process Public Health Reporting Risk Role Safety Schools Science Scientist Shapes Small Business Innovation Research Grant Social Interaction Statutes and Laws Stress Structure Students Testing Time Translations Universities Vertebral column Visual Visualization Work college cost education cost epigenetic regulation epigenome experience experimental study falls fetal fictional works fungus genetic makeup grasp hands-on learning health disparity health literacy high school human disease improved in silico innovation junior high school learning outcome man member model organism novel offspring online delivery response risk mitigation success tool undergraduate student web based software

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项目摘要

Project Summary NIEHS defines environmental health as “the field of science that studies how the environment influences human health and disease”. The environment in this definition includes the natural environment, man-made chemicals and structures that often pollute the natural environment, and our social interactions and lifestyle choices. Because toxic environments are linked directly to human health and disease, a critical need exists to educate the American population on this relationship to allow us to make informed choices about the amount of risk we are willing to take. Stated differently, to improve public health we need to improve environmental health literacy (EHL), the goal of RFA-ES-21-008 (Innovative Approaches for Improving Environmental Health Literacy). The RFA requests collaborations between small businesses and environmental scientists “to develop novel tools, activities, or materials to build EHL”. In response, Nzumbe Inc. has partnered with media experts (SquishyMedia) environmental and education scientists at Oregon Health & Science University, Oregon State University and local undergraduate institutions to submit this proposal. Our strategy is to use epigenetic science as an education bridge to improve EHL because the basics of this science are relatively easy to understand and the epigenome responds to environmental exposures in ways that can improve or worsen health. To accomplish this goal, our SBIR Phase I and now our Phase II application focuses on developing two “experiential” educational tools. The first tool, delivers interactive learning modules in an online software application that utilizes “gamification” principles to teach users how the environment impacts our epigenome and health as a consequence. Gamification offers a variety of benefits associated with learning outcomes, including enhancing user-engagement, learning, and knowledge retention. Our software application will include the “EpiMon” app, a stylized interactive game that will utilize the epigenetic principles that the student has learned and apply them to fictional creatures (EpiMon) in a fictional world. The second tool, is an educational laboratory kit that will emphasize and tie in principles taught with the software product. The lab kit utilizes a simple and safe model organism, Neurospora crassa, to demonstrate basic epigenetic principles and how environmental exposures can influence the epigenetic regulation of gene expression. While the kit will contain control experiments to demonstrate these principles, it will also offer the students the ability to experiment with growth conditions to determine their impact on epigenetic gene regulation. Unlike most laboratory kits in the marketplace where the experimental outcome is pre-determined, the experiential approach of our kit puts the keys in the hands of the student. Results will be reported to an accompanying software application module where students can compare their results with classmates and other schools to identify exposures with epigenetic activity. Successful completion of the proposed work will enable us to extend these tools to public school students and the interactive software to the lay public and public health professionals at little to no cost.

项目摘要 NIEHS将环境健康定义为“研究环境如何影响的科学领域人类健康和疾病”。此定义中的环境包括自然环境，人造环境通常污染自然环境的化学和结构，以及我们的社会互动和生活方式选择。由于有毒环境与人类健康和疾病直接相关，因此存在关键需求教育美国人口这种关系，使我们能够对冒险我们愿意承担。陈述不同，为了改善公共卫生，我们需要改善环境健康 RFA-ES-21-008的目标（EHL）（EHL）（改善环境健康的创新方法扫盲）。 RFA要求小型企业与环境科学家之间的合作“开发新的工具，活动或材料来构建EHL”。作为回应，Nzumbe Inc.已与媒体专家合作俄勒冈州俄勒冈州健康与科学大学的环境和教育科学家（SquishyMedia）大学和地方本科机构提交该建议。我们的策略是使用表观遗传学科学作为改善EHL的教育桥梁，因为该科学的基础知识相对容易了解和表观基因组对环境暴露的反应，以改善或更糟的方式健康。为了实现这一目标，我们的SBIR第一阶段和现在的第二阶段应用程序着重于开发两个 “体验式”教育工具。第一个工具，在线软件中提供交互式学习模块利用“游戏化”原则来教用户环境如何影响我们的表观基因组的应用程序结果是健康。游戏化提供了与学习成果相关的各种好处，包括增强用户参与，学习和知识保留。我们的软件应用程序将包括 “ Epimon”应用程序是一种风格化的互动游戏，它将利用学生拥有的表观遗传原理在虚构的世界中学习并将其应用于虚构的奶油（Epimon）。第二个工具是一种教育实验室套件将强调并以软件产品教授的原则进行联系。实验室套件利用简单且安全的模型生物，神经孢子骨，以展示基本的表观遗传原理以及如何环境暴露会影响基因表达的表观遗传调节。而套件将包含控制实验以证明这些原则，它也将为学生提供实验的能力生长条件以确定其对表观遗传基因调节的影响。与大多数实验室套件不同实验结果预先确定的市场，我们套件的专家方法使钥匙掌握在学生手中。结果将报告给认可的软件应用程序模块学生可以将他们的结果与同学和其他学校进行比较，以确定暴露表观遗传活性。成功完成拟议的工作将使我们能够将这些工具扩展到公众学校的学生以及向外行公共和公共卫生专业人员提供的交互式软件，几乎没有成本。