Understanding how endocrine disruptors and chemical mixtures of concern target the immune system to trigger or perpetuate disease (ENDOMIX)

了解内分泌干扰物和相关化学混合物如何针对免疫系统引发或延续疾病 (ENDOMIX)

• 批准号: 10106479
• 金额: $ 49.73万
• 依托单位: IMPERIAL COLLEGE LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10106479
• 关键词: Understanding; how; endocrine; disruptors; chemical

The ENDOMIX project addresses the urgent need to understand the true impact of endocrine disrupting chemicals (EDCs) on human health in order to inform regulators and advise citizens. ENDOMIX will tackle this challenge by revealing associations and causality between EDCs and adverse health outcomes by focusing on exposure to multiple EDCs during life course including windows of susceptibility and making use of already existing robust data from multiple European cohorts. Modelling how real-life EDC mixtures target the immune system to initiate, trigger or perpetuate diseases combined with high throughput bioassays will reveal health-relevant mixtures of concern whose impact will be studied using ground-breaking methodology while delivering valuable information on mechanistic pathways and transgenerational impact of exposure to EDCs. This strategy will lead to the identification of biomarkers and patterns of exposure that are easy to measure, available for big sample sizes, and indicative of health endpoints. Finally, we will provide evidence synthesis of in vitro, in silico and in vivo data for strengthening causal inference and use a weight of evidence approach to generate artificial intelligence-assisted knowledge graphs. This unique loop approach with a novel focus on the immune system as EDC target is only made possible by the consortium’s interdisciplinary expertise and extensive access to existing data and biosamples as well as a meticulous study design. The knowledge generated by this consortium will be disseminated to the scientific community provide a thorough new evidence base for policy making and will reach citizens of all ages to raise awareness about the risks of EDC exposure and promote health-preserving behaviour. Hence, the outcomes of ENDOMIX do not only provide essential new knowledge and understanding but also and have far-reaching implications for the health and well-being of society, including significant savings in European health care systems.

ENDOMIX 项目解决了了解内分泌干扰化学品 (EDC) 对人类健康的真正影响的迫切需要，以便向监管机构提供信息并为公民提供建议。 ENDOMIX 将通过重点关注内分泌干扰化学品 (EDC) 与不良健康结果之间的关联和因果关系来应对这一挑战。在生命过程中接触多种 EDC，包括易感性窗口，并利用来自多个欧洲队列的现有可靠数据对现实生活中的 EDC 混合物如何针对免疫系统启动、触发或进行建模。永久性疾病与高通量生物测定相结合将揭示与健康相关的混合物，将使用突破性的方法研究其影响，同时提供有关 EDC 暴露的机制途径和跨代影响的有价值的信息。最后，我们将提供体外、计算机和体内数据的证据综合，以加强因果推断和使用。这种独特的循环方法以免疫系统为 EDC 目标，只有通过该联盟的跨学科专业知识和对现有数据和生物样本的广泛访问才能实现。该联盟产生的知识将传播给科学界，为政策制定提供彻底的新证据基础，并将惠及所有年龄段的公民，以提高对 EDC 暴露风险的认识并促进健康保护行为。 , ENDOMIX 的成果不仅提供了重要的新知识和理解，而且对社会的健康和福祉产生了深远的影响，包括为欧洲医疗保健系统节省大量资金。