Impact of local network dynamics on visual cortex function

局部网络动态对视觉皮层功能的影响

• 批准号: 8060553
• 负责人: JESSICA A CARDIN
• 金额: $ 23.9万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8060553
• 关键词: Address; Animals; Behavioral; Brain; Chronic; Custom; Data; Discrimination; Elements; Foundations; Future; Goals; Implant; Individual; Laboratories; Measures; Mediating; Mentors; Neurons; Output; Perception; Phase; Play; Population; Population Dynamics; Process; Research; Role; Sensory; Series; Solid; Staging; Stimulus; Synapses; System; Techniques; Training; Visual; Visual Cortex; Visual Perception; Work; area striata; awake; design; experience; extracellular; innovation; insight; novel; novel strategies; operation; research study; response; sensory mechanism; stimulus sensitivity; visual process; visual processing; visual stimulus; Address; Animals; Behavioral; Brain; Chronic; Custom; Data; Discrimination; Elements; Foundations; Future; Goals; Implant; Individual; Laboratories; Measures; Mediating; Mentors; Neurons; Output; Perception; Phase; Play; Population; Population Dynamics; Process; Research; Role; Sensory; Series; Solid; Staging; Stimulus; Synapses; System; Techniques; Training; Visual; Visual Cortex; Visual Perception; Work; area striata; awake; design; experience; extracellular; innovation; insight; novel; novel strategies; operation; research study; response; sensory mechanism; stimulus sensitivity; visual process; visual processing; visual stimulus

The long-term objective ofthis project is to contribute to our understanding ofthe mechanisms of visual representation by cortical networks. Neuronal gain, measured as the continuous slope ofthe relationship between stimulus input and cellular outpiut, is a measure of neuronal sensitivity to the stimulus and a defining element ofthe contribution of single neurons to network operations. Previous work has identified a role for network-driven synaptic activity in modulating the input-output gain of cortical neurons. In addition, synchroiQ' between local network mputs may determine the magnitude ofthe impact of network activity on neuronal gain. Previous studies have also suggested that gain modulation and population synchrony play roles in mediating visual perception. However, even at the earliest stages of cortical visual processing, die relationship between individual neurons and the surrounding local network is poorly understood. The main goals ofthe work proposed here are therefore 1) to determine the relationship betweoi cellular mechanisms of contrast gain control and networic synchrony and 2) to examine tiie interacti(H) between population synchrony and visual perception. To tiiat end, the first Aim focused on many simultaneous recordings of cortical neurons during presentation of stimuli with varying prqierties. The second Aim will use a behavioral task in which awake bdiaving animals discriminate between visual stimuli of vaiying contrast In one series of expraiments, tiiis task will be combined witii population recordings of neimms that make up local netwoiks in primary visual cortex. The results of these eiqieriments are expected to provide novel insights into the relation^p between tiie temporal dynamics of population activity and cellular mechanisms of gain control. In addition, they will graierate a better understanding of tiie role of synchronous cortical networic activity in visual perception.

这个项目的长期目标是有助于我们理解视觉表示机制 由皮质网络。神经元增益，以刺激输入与 细胞支出是对刺激的神经元灵敏度的量度，也是单个贡献的定义元素 神经元进行网络操作。以前的工作已经确定了网络驱动的突触活动的作用 皮质神经元的输入输出增益。此外，本地网络mputs之间的同步性可以确定 网络活动对神经元增益的影响的大小。先前的研究还表明 调制和种群同步在介导视觉感知中起着作用。但是，即使在最早的阶段 皮质视觉处理，单个神经元与周围局部网络之间的死亡关系很差 理解。因此，这里提出的工作的主要目标是1）确定蜂窝的关系 对比度增益控制和网络同步的机制，以及2）检查人群之间的TIIE Itsptimi（H） 同步和视觉感知。最后，第一个目的集中在许多同时记录皮质上 神经元在以不同的刺激呈现刺激期间。第二个目标将使用行为任务 清醒的动物在一系列征用，TIIIS任务中区分自动对比的视觉刺激 将被合并为Neimms的WITII人口记录，这些记录构成了主要视觉皮层中本地Netwoiks。这 这些eiqieriments的结果有望提供有关时间动力学之间关系^p的新见解 增益控制的种群活性和细胞机制。此外，他们将更好地理解 同步皮质净化活性在视觉感知中的作用。