MRI-compatible BrainPET Scanner

兼容 MRI 的 BrainPET 扫描仪

• 批准号: 10505319
• 负责人: Ciprian Catana
• 金额: $ 60万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10505319
• 关键词: 15 year old; AIDS/HIV problem; Accounting; Address; Aging; Agreement; Anxiety Disorders; Award; Bipolar Disorder; Boston; Brain; Communities; Development; Devices; Failure; Funding; Goals; Head; Human; Leadership; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Mental Depression; Mental Health; Mental disorders; Methods; Modality; National Institute of Mental Health; Neurosciences; Performance; Positron-Emission Tomography; Price; Radiochemistry; Radiology Specialty; Research; Research Personnel; Schedule; Schizophrenia; Services; System; Technology; United States National Institutes of Health; autism spectrum disorder; data acquisition; detector; healthy volunteer; human subject; imaging modality; improved; instrument; nervous system disorder; nonhuman primate; patient population; programs; prototype; research study; substance use; traumatic event

Project Summary/Abstract This application seeks support from NIMH to purchase the 3-Tesla magnetic resonance (MR)-compatible positron emission tomography (PET) brain scanner manufactured by Cubresa, Inc. PET and MRI are two of the most powerful imaging modalities currently in use for studying the human brain. Scanners capable of simultaneous PET and MR whole-body data acquisition in human subjects became commercially available a decade ago. However, until recently, there was no equivalent dedicated head device on the market to address the needs of the researchers and clinicians focusing on the brain and the performance of whole-body devices is rather limited for this purpose. A high-performance MR-compatible BrainPET scanner installed at the Martinos Center would benefit many brain-focused research studies in our center and in the community. The Cubresa BrainPET would replace the Siemens BrainPET prototype that was installed at the Martinos Center in May 2008 and has served our investigators effectively for more than a decade. It was moved in the Martinos Center PET & Radiochemistry Facility in June 2011 and became the workhorse of our PET program for many years even after the installation of the Biograph mMR. At peak usage, three-dozen projects were using the BrainPET prototype in a variety of studies ranging from those aimed at characterizing the scanner performance, developing methods to use the information obtained from one device to improve the other modality, and demonstrating the tremendous potential of this technology through proof-of-principle studies in non-human primates, healthy volunteers, and numerous patient populations. However, with the exceedingly fast PET detector developments seen in the last decade, the 15+ year old technology has now become outdated. The service agreement for the BrainPET prototype ended 5 years ago and the prototype has been non-functional for about a third of 2021 due to technical failures. Therefore, a replacement of this aging and obsolete system will be necessary to enhance and complete the scientific goals and aims of the ongoing projects focused on several mental disorders and related topics (i.e., anxiety disorders, autism spectrum disorder, bipolar disorder, depression, HIV/AIDS and mental health, schizophrenia, substance use, traumatic events) as well as on neurological diseases and basic neuroscience. The installation of the new instrument is being supported by the MGH leadership, Radiology Department, and Martinos Center. This multi-level institutional support covers allocation of instrument space and assistance for installation, operational support in terms of system scheduling, accounting, and maintenance, and lastly, a commitment of up to $278,000 to cover the gap between the NIH SIG award and the purchasing price for the upgrade, in addition to the committed funds of $100,000 from the MGH Executive Committee for Research. Following the installation, the Cubresa BrainPET will be managed by the Martinos Center as a shared core, and made available to the broader research community, both within MGH and the Greater Boston region.

项目摘要/摘要 该应用程序寻求NIMH的支持，以购买3-TESLA磁共振（MR）合并 Cubresa，Inc。PET和MRI生产的正电子发射断层扫描（PET）脑扫描仪是其中两个 目前正在使用最强大的成像方式来研究人脑。扫描仪 人类受试者的同时宠物和全身数据获取成为商业上的 十年前。但是，直到最近，市场上还没有等效的专用头设备来解决 研究人员和临床医生专注于大脑的需求和全身设备的性能是 为此目的而有限。马提尼斯安装的高性能MR兼容Brainpet扫描仪 中心将使我们中心和社区中的许多以脑部为重点的研究受益。 Cubresa Brainpet将取代2008年5月在Martinos中心安装的西门子的Brainpet原型 并有效地为我们的研究人员服务了十多年。它在马提诺斯中心宠物中被移动 ＆放射化学设施于2011年6月，甚至成为我们宠物计划的主力多年 安装生物MMR之后。在高峰使用时，三个项目正在使用Brainpet 各种研究中的原型，从旨在表征扫描仪性能的旨在进行的研究等等 使用从一台设备获得的信息来改善另一种方式的方法，并演示 这项技术通过非人类灵长类动物的原理研究的巨大潜力，健康 志愿者和众多患者人群。但是，随着宠物探测器的发展非常快 在过去的十年中，这项15岁以上的技术已经过时了。服务协议 Brainpet原型于5年前结束，该原型在2021年的三分之一的时间里是非功能 技术失败。因此，需要更换这种老化和过时的系统以增强 并完成正在进行的项目的科学目标和目标，该项目集中在多种精神障碍上， 相关主题（即焦虑症，自闭症谱系障碍，躁郁症，抑郁症，艾滋病毒/艾滋病 心理健康，精神分裂症，药物使用，创伤事件）以及神经疾病和基本疾病 神经科学。新工具的安装得到了MGH领导力，放射学的支持 部门和马蒂诺斯中心。这种多层次的机构支持涵盖了仪器空间的分配， 协助安装，在系统调度，会计和维护方面的运营支持以及 最后，最高278,000美元的承诺涵盖了NIH SIG奖与购买价格之间的差距 对于升级 研究。安装后，Cubresa Brainpet将由Martinos Center作为共享 核心，并在MGH和大波士顿地区内提供了更广泛的研究社区。