Sustainable and adaptable manufacturing of Gold Nanoparticles for use in Biomedical Diagnostics

用于生物医学诊断的金纳米粒子的可持续和适应性制造

• 批准号: 10103609
• 金额: $ 27万
• 依托单位: GROVE NANOMATERIALS LIMITED
• 依托单位国家: 英国
• 项目类别: Investment Accelerator
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10103609
• 关键词: Sustainable; adaptable; manufacturing; Gold; Nanoparticles

The use of gold nanoparticles to create the red lines in a home Covid test is one of the great triumphs of nanotechnology. We all know the colour of gold, but nano-gold is red, soluble in water and one can bind it to molecules which detect a particular disease; thus the gold nanoparticles visualise the presence of an infectious agent. Grove Nanomaterials Ltd has developed, tested, and validated to proof-of-concept stage, a novel technology (CoVap) for producing functionalised gold nanoparticles directly from metal sources, and in a sustainable way that avoids toxic chemicals. Their incorporation into 'Lateral Flow Tests' (LFTs) will enable the detection not only of infections like Covid or Flu but also potential allergens such as gluten or lactose in food testing or conditions such as pregnancy.This project will scale-up Grove's manufacturing capability to produce gold nanoparticles with diverse chemical conjugations, that are rapidly tuneable to meet customer needs for diagnostic devices to address future medical or health threats. Working closely with device developers and OEMs, our agile and responsive manufacturing approach uses a novel 'in-vacuo synthesis' process, meaning that Grove can rapidly supply batch quantities at low cost to customers and/or end-users. Moreover, the product will be available in various formats, either "dry" as a stable nanocomposite of nanoparticles within a relevant organic/polymeric matrix, or dispersed into a stable, colloidal solution), and in a variety of sizes and colours to meet specific diagnostic requirements (e.g. Covid, Flu, Gluten or Pregnancy)With proof-of-concept already established, and the diagnostic devices market targeted (particular Lateral Flow Tests, LFTs) as major user of gold nanoparticles, this project will scale-up Grove's manufacturing capability and product range through further and essential R&D, whilst ensuring compliance with customer needs.Key activities in this project include:* R&D: Advancing our technology to TRL8/9 through refinement of process control, extending the range of proven functionalisation's, and material characterisation* Validation of our nanoparticles within LFT applications, through testing with three industry partners. 'Abbott Laboratories -- Lateral Flow Tests for Covid; 'Abingdon Health' -- Flu and Pregnancy Tests; 'Bio-Check' -- Food allergen tests* Exploitation planning, cost/performance modelling and further IP protection* Explore Grove's recent discoveries of 'navy blue' and 'fluorescent' gold nanoparticles for their use in dual-diagnostic devices (i.e. to detect 2 different diseases using a single LFT)To deliver this technology into the rapidly expanding nanoparticulate materials market, Grove has secured ~ £250k of external leveraged funding

使用金纳米颗粒在家庭互联测试中创建红线是纳米技术的巨大胜利之一。我们都知道黄金的颜色，但是纳米金是红色的，可溶于水，可以将其与检测特定疾病的分子结合。因此，金纳米颗粒可视化感染剂的存在。格罗夫纳米材料有限公司已经开发，测试和验证了概念验证阶段，这是一种直接从金属来源生产功能化的金纳米颗粒的新技术（COVAP），并以可持续的方式避免有毒化学物质。它们将其纳入“横向流程测试”（LFT）不仅可以检测到诸如互联或流感等感染，还可以在食品测试中或诸如怀孕等状况中的潜在过敏原，例如麸质或乳糖。该项目将扩大格罗夫的制造能力，以确定具有多样化的化学成分，以适应诊断的诊断，从而使杂物化的化学成分可用于诊断型诊断。与设备开发人员和OEM紧密合作，我们的敏捷和响应式制造方法使用了一种新颖的“ Vacuo合成”过程，这意味着Grove可以以低成本向客户和/或最终用户迅速提供批处理数量。此外，该产品将以各种格式提供，作为“干燥”作为稳定的纳米颗粒的稳定纳米复合材料，在相关的有机/聚合物矩阵中，或分散成稳定的胶体溶液中），以及各种尺寸和颜色，以及各种尺寸和颜色，以满足特定的诊断，以验证特定的诊断，并具有特定的诊断，并具有特定的诊断，并具有诊断的诊断，并具有诊断性的诊断，并符合诊断的诊断，并符合诊断的诊断（及时诊断）。 Flow Tests, LFTs) as major user of gold nanoparticles, this project will scale-up Grove's manufacturing capability and product range through further and essential R&D, whilst ensuring compliance with customer needs.Key activities in this project include:* R&D: Advancing our technology to TRL8/9 through refinement of process control, extending the range of proven functionalisation's, and material characterisation* Validation of our nanoparticles within LFT applications, through与三个行业合作伙伴进行测试。 '雅培实验室 - 共同的横向流程测试； “ Abingdon Health” - 流感和妊娠试验； “生物检查” - 食物过敏原检验*剥削计划，成本/性能建模和进一步的IP保护*探索格罗夫最近发现的“海军蓝色”和“荧光”金纳米颗粒在双诊断设备中用于双诊断设备（即使用单个LFT进行两种不同的材料，可以将22个不同的材料传递到£25的范围内），以实现22个不同的疾病，以实现25次范围。利用资金