Motion Processing in the Superior Colliculus

上丘的运动处理

基本信息

批准号：
10474440
负责人：
Jianhua Cang
金额：
$ 36.3万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-12-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10474440
关键词：
Affect Animals Area Behavior Behavioral Brain Calcium Data Disease Dyslexia Environment Foundations Genetic Goals Grant Head Image Individual Location Locomotion Maps Mediating Mental disorders Methodology Midbrain structure Modeling Motion Motor Movement Mus Nervous system structure Neurons Physiological Preparation Process Property Research Research Personnel Retina Running Schizophrenia Sensory Series Signal Transduction Speed Stimulus Synapses System Transgenic Mice Vertebrates Viral Vision Vision research Visual Visual Cortex Visual system structure Whole-Cell Recordings autism spectrum disorder awake brain circuitry cell type excitatory neuron experimental study ganglion cell in vivo inhibitory neuron insight multimodality nervous system disorder neural circuit neuromechanism novel object motion optic flow optogenetics receptive field relating to nervous system response retinotopic sensory system signal processing superior colliculus Corpora quadrigemina tool treadmill two-photon virtual reality environment virtual reality system visual information visual processing visual stimulus

项目摘要

Project Summary/Abstract How visual information is processed and transformed in the nervous system is a fundamental question in vision research. Given its clear importance in visually-guided behaviors and the available genetic tools, the mouse superior colliculus (SC) holds great promise for understanding visual processing and its neural mechanisms. The SC is a midbrain structure important for multimodal integration and sensorimotor transformation. Its superficial layers are purely visual and receive direct inputs from the retina. In this proposal, the investigators will study motion processing in a visual layer of the SC, the SGS, with a particular focus on its modulation by stimulus context, locomotion state, and self-generated visual flow. First, in vivo whole cell recording will be performed to determine the synaptic inputs that individual SGS neurons receive from the region surrounding their receptive fields. These experiments will reveal the local connectivity of excitatory and inhibitory neurons that mediates the bidirectional encoding of motion contrast between the visual stimulus and its context. Second, two-photon calcium imaging will be performed in awake mice to determine whether and how locomotion affects visual responses in the SGS. These experiments will be done across the depth of the SGS and in a cell- type-specific manner. Finally, the investigators will study whether and how self-generated visual flow affects the responses of SGS neurons. Two-photon imaging and physiological recording will be performed in head- restrained mice running in a virtual reality system. These experiments will be conducted across different retinotopic locations in the SGS, in order to reveal whether a region-specific organization exists in the SGS in the context of encoding self-generated motion. Together, these experiments will generate important data needed for a complete understanding of visual processing in the brain. Because normal visual processing is compromised in a number of neurological and psychiatric disorders, such as dyslexia, schizophrenia, and autism spectrum disorders, these studies will provide novel insights for the understanding and treatment of these disorders.

项目摘要/摘要在神经系统中如何处理和转换视觉信息是一个基本问题在视觉研究中。鉴于其在视觉引导的行为和可用遗传工具中的重要性小鼠上丘（SC）具有理解视觉处理及其神经的巨大希望机制。 SC是一种对多模式整合和感觉运动重要的中脑结构转型。它的浅层层纯粹是视觉的，并从视网膜接收直接输入。在此提案中，调查人员将在SC的视觉层中研究运动处理，以特别关注其通过刺激上下文，运动状态和自我生成的视觉流进行调节。首先，体内整个细胞将进行记录以确定单个SGS神经元从该区域收到的突触输入围绕他们的接收场。这些实验将揭示兴奋性和抑制性的局部连通性介导视觉刺激及其背景之间运动对比的双向编码的神经元。第二，将在清醒小鼠中进行两光子钙成像，以确定是否运动以及如何运动影响SGS中的视觉反应。 These experiments will be done across the depth of the SGS and in a cell- 特定于类型的方式。最后，调查人员将研究自我生成的视觉流以及如何影响 SGS神经元的反应。两光子成像和生理记录将在头部进行在虚拟现实系统中运行的约束小鼠。这些实验将跨不同 SGS中的视网膜位置，以揭示SGS中是否存在特定地区的组织编码自我生成运动的背景。这些实验将共同生成所需的重要数据为了完全了解大脑中的视觉处理。因为正常的视觉处理是在许多神经系统和精神疾病中受到妥协，例如阅读障碍，精神分裂症和自闭症这些研究将为理解和处理这些研究提供新的见解疾病。

项目成果

期刊论文数量（27）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

In vivo imaging of the inner retinal layer structure in mice after eye-opening using visible-light optical coherence tomography.

DOI：
10.1016/j.exer.2021.108756
发表时间：
2021-10
期刊：
EXPERIMENTAL EYE RESEARCH
影响因子：
3.4
作者：
Beckmann, Lisa;Cai, Zhen;Cole, James;Miller, David A.;Liu, Mingna;Grannonico, Marta;Zhang, Xian;Ryu, Hyun Jung;Netland, Peter A.;Liu, Xiaorong;Zhang, Hao F.
通讯作者：
Zhang, Hao F.

Retinal origin of direction selectivity in the superior colliculus.

上丘方向选择性的视网膜起源