Administrative Core

行政核心

基本信息

批准号：
10474588
负责人：
JAMES Bruce LEVERENZ
金额：
$ 70.6万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10474588
关键词：
Address Administrator Advisory Committees Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Biological Markers Biology COVID-19 Clinic Clinical Collaborations Communities Data Dementia Development Disease Progression Enrollment Ensure Faculty Fostering Foundations Funding Goals Guidelines Heterogeneity Institution Institutional Review Boards International Intervention Lead Medical Medical center Modification Molecular Monitor Nerve Degeneration Ohio Pathologic Process Program Research Project Grants Protocols documentation Research Research Personnel Research Support Risk Factors Role Sampling Site Students System Time Training Programs Training Support Translating Translational Research United States Department of Veterans Affairs United States National Institutes of Health Universities University Hospitals Veterans Visit Work base data exchange data management ethnic minority human subject imaging biomarker meetings member neuroimaging neuropathology outreach prevent programs protective factors racial minority recruit repository statistics success transmission process

项目摘要

PROJECT SUMMARY The Cleveland Alzheimer's Disease Research Center (CADRC) is a collaborative effort of investigators at five Cleveland area institutions: Case Western Reserve University (CWRU), Cleveland Clinic Foundation (CCF), MetroHealth Systems (MHS), University Hospitals (UH), and the Louis Stokes Cleveland Veterans Affairs Medical Center (LSCVAMC). The Administrative Core (AC) of the CADRC has the overall responsibility for promoting the successful integration of the participating sites and investigators and the successful completion of the Center's goals. The AC works closely with the other cores to achieve the aims of the CADRC and milestones of the National Alzheimer's Project Act. In addition, the AC has a unique role in the CADRC of promoting close collaboration between CADRC investigators, Cores, local neurodegeneration research investigators, and local community leaders to foster an active center of Alzheimer's disease (AD) and AD- related dementias (ADRD).The AC has primary responsibility for coordinating and leading CADRC group activities including weekly AC/administrator meetings, monthly Core leaders meeting, the twice yearly Internal Advisory Committee (IAC) meetings, and annual External Advisory Committee (EAC) visits. These meetings review the activities and accomplishments of the cores, ensures timely transmission of CADRC data and biospecimens to the National Alzheimer's Coordinating Center (NACC) and National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), and fosters additional collaborations between cores (Specific Aim 1). The AC also provides external support and advice to the CADRC investigators on advancing the goals and aims of the center (Specific Aim 2) and promotes interactions with other Alzheimer Disease Research Centers, collaborations and opportunities for additional funding (Specific Aim 4). The AC provides compliance oversight and obtains/renews centralized institutional review board approval of CADRC activities (Specific Aim 3). Lastly, the AC oversees and promotes training and support to students, fellows, and junior faculty through the establishment of an annual Development Project Grant Program (Specific Aim 5).

项目摘要克利夫兰阿尔茨海默氏病研究中心（CADRC）是研究人员的合作努力克利夫兰五个地区机构：克利夫兰诊所基金会凯斯西部储备大学（CWRU）（CCF），Metrohealth Systems（MHS），大学医院（UH）和路易斯·斯托克斯（Louis Stokes）克利夫兰退伍军人事务医疗中心（LSCVAMC）。 CADRC的行政核心（AC）具有总体责任促进参与站点和调查人员的成功整合以及成功的完成中心的目标。 AC与其他内核紧密合作，以实现CADRC的目标以及《国家阿尔茨海默氏症计划法》的里程碑。此外，AC在CADRC中具有独特的作用促进CADRC研究人员，核心，本地神经变性研究之间的密切合作调查人员和当地社区领导人培养一个活跃的阿尔茨海默氏病（AD）和AD- 相关痴呆症（ADRD）。AC对协调和领导CADRC组负有主要责任活动包括每周一次的AC/管理员会议，每月核心领导会议，每年两次内部咨询委员会（IAC）会议和年度外部咨询委员会（EAC）访问。这些会议查看核心的活动和成就，确保及时传输CADRC数据和到国家阿尔茨海默氏症协调中心（NACC）和国家集中库的生物测量阿尔茨海默氏病和相关痴呆症（NCRAD），并培养了核心之间的其他合作（特定目标1）。 AC还向CADRC调查人员提供了外部支持和建议中心的目标和目标（特定目标2）并促进与其他阿尔茨海默氏病的互动研究中心，合作和额外资金的机会（特定目标4）。交流提供合规性监督并获得/更新集中的机构审查委员会批准CADRC活动（特定目标3）。最后，AC监督并促进了对学生，研究员和初中的培训和支持通过建立年度发展项目赠款计划（特定目的5），教师。