Cleveland Alzheimers Disease Research Center

克利夫兰阿尔茨海默病研究中心

• 批准号: 10675648
• 负责人: JAMES Bruce LEVERENZ
• 金额: $ 307.19万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675648
• 关键词: Acceleration; Address; African American; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Autopsy; Behavioral; Biological Markers; Biology; Brain; Brain Diseases; Cessation of life; Clinic; Clinical; Cognitive; Collaborations; Collection; Communities; Consent; Data; Dementia; Dementia with Lewy Bodies; Development; Diagnosis; Disease; Disease Progression; Early identification; Enrollment; Ensure; Evaluation; Financial Support; Fostering; Foundations; Freezing; Funding; Genetic; Genetic Risk; Goals; Heterogeneity; Human; Image; Impairment; Individual; Infrastructure; Institution; International; Intervention; Laboratory Finding; Link; Magnetic Resonance Imaging; Medical center; Memory; Molecular; Monitor; Motor; National Institute on Aging; Ohio; Participant; Pathologic; Pathology; Persons; Phenotype; Physicians; Population; Professional Education; Research; Research Design; Research Personnel; Resources; Risk; Risk Factors; Scientist; Speed; Standardization; System; Tissue Sample; Tissues; Training; Translating; Translational Research; Translations; Underrepresented Populations; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; University Hospitals; Veterans; amyloid imaging; career; career development; cell repository; cohort; collaborative environment; community center; data management; data repository; demented; design; drug discovery; education research; ethnic minority; health disparity; high risk; improved; individualized medicine; insight; mild cognitive impairment; neuroimaging; neuropathology; next generation; novel therapeutics; outreach; participant retention; patient engagement; precision medicine; programs; protective factors; racial minority; recruit; shared repository; social stigma; statistics; success; targeted biomarker; therapeutic target; tool; translational therapeutics

PROJECT SUMMARY The Cleveland Alzheimer's Disease Research Center (CADRC) is a collaborative effort of physicians and investigators from Case Western Reserve University (CWRU), Cleveland Clinic Foundation (CCF), MetroHealth System (MHS), University Hospitals (UH), and the Louis Stokes Cleveland VA Medical Center (LSCVAMC), to foster excellence in research and facilitate discovery as an established National Institute on Aging (NIA) funded Alzheimer's Disease Research Center. The CADRC represents a rich clinical and research community and an estimated 220,000 Ohioans who suffer from Alzheimer's disease (AD) or AD-related dementias (ADRD). The CADRC has 8 Cores and a Research Education Component designed to create the foundation that will enhance the research efforts of the Northeast Ohio AD/ADRD research community, as well as add unique value to the national Alzheimer's Disease Research Centers (ADRC) program and other national and international research programs. The CADRC is focused on participants that will help us understand the pathobiology of clinical and pathological heterogeneity observed in dementia including atypical and amnestic AD, dementia with Lewy bodies, cognitively normal individuals with different levels of genetic risk for AD, and diversity of participant populations (Clinical and Outreach, Recruitment, and Engagement Cores). To support the CADRC goals, the focus will be on deep phenotyping of participants with longitudinal and systematic cognitive, behavioral and motor characterization (Clinical Core), genetic and biofluid biomarker collection and analysis (Biomarker Core), imaging (Neuroimaging Core), and autopsy after death (Neuropathology Core). Results will be shared with the research community in a timely and regular manner to allow other investigators to benefit from the CADRC efforts (Data Management and Statistics Core). In addition, the CADRC will train the next generation of investigators utilizing a rigorous and well-designed Research Education Component, support translation of new laboratory findings through the Translational Therapeutics Core, and support high risk/high gain projects through the developmental program as a part of the Administrative Core. The ultimate goals are to advance the precision medicine approach to dementia diagnosis and treatment, support the development of early stage investigators, assist all stages of investigators with tools for performing human-based research, and better engage underrepresented populations in AD/ADRD research.

项目概要 克利夫兰阿尔茨海默病研究中心 (CADRC) 是医生们的共同努力 以及来自凯斯西储大学 (CWRU)、克利夫兰诊所基金会 (CCF) 的研究人员， MetroHealth System (MHS)、大学医院 (UH) 和 Louis Stokes Cleveland VA 医疗中心 (LSCVAMC)，作为一个已建立的国家研究所，促进卓越的研究并促进发现 老龄化 (NIA) 资助的阿尔茨海默病研究中心。 CADRC 代表了丰富的临床和研究 社区和估计 220,000 名患有阿尔茨海默病 (AD) 或 AD 相关疾病的俄亥俄州人 痴呆症（ADRD）。 CADRC 有 8 个核心和一个研究教育组件，旨在创建 该基金会还将加强俄亥俄州东北部 AD/ADRD 研究界的研究工作 为国家阿尔茨海默病研究中心 (ADRC) 计划和其他项目增添独特价值 国家和国际研究计划。 CADRC 重点关注能够帮助我们的参与者 了解痴呆症（包括非典型痴呆症）中观察到的临床和病理异质性的病理学 健忘性AD、路易体痴呆、认知正常但具有不同程度遗传风险的个体 AD 以及参与者人群的多样性（临床和外展、招募和参与核心）。 为了支持 CADRC 的目标，重点将放在参与者的纵向和深度表型分析上。 系统认知、行为和运动特征（临床核心）、遗传和体液生物标志物 收集和分析（Biomarker Core）、成像（Neuroimaging Core）以及死后尸检 （神经病理学核心）。结果将及时、定期与研究界共享，以 允许其他研究人员从 CADRC 的工作（数据管理和统计核心）中受益。在 此外，CADRC 将利用严格且精心设计的课程来培训下一代调查人员 研究教育部分，通过转化支持新实验室发现的转化 治疗核心，并通过开发计划支持高风险/高收益项目，作为 行政核心。最终目标是推进针对痴呆症的精准医学方法 诊断和治疗，支持早期研究者发展，协助各阶段研究者 拥有进行以人为本的研究的工具，并更好地让代表性不足的人群参与 AD/ADRD 研究。

项目成果

Increased Risk of Dementia Among Veterans With Bipolar Disorder or Schizophrenia Receiving Care in the VA Health System.

• DOI: 10.1176/appi.ps.201900325
• 发表时间: 2020-10-01
• 期刊: Psychiatric services (Washington, D.C.)
• 作者: Ahearn EP;Szymanski BR;Chen P;Sajatovic M;Katz IR;McCarthy JF
• 通讯作者: McCarthy JF

Overcoming barriers to informed consent in neurological research: Perspectives from a national survey.

• DOI: 10.1177/17470161221131497
• 发表时间: 2023-01
• 期刊: RESEARCH ETHICS
• 影响因子: 1.7
• 作者: Sankary, Lauren R.;Zelinsky, Megan E.;Ford, Paul J.;Blackstone, Eric C.;Fox, Robert J.
• 通讯作者: Fox, Robert J.

The state of loneliness and social isolation research: current knowledge and future directions.

• DOI: 10.1186/s12889-023-15967-3
• 发表时间: 2023-06-01
• 期刊: BMC public health
• 影响因子: 4.5

High-resolution functional connectivity of the default mode network in young adults with down syndrome.

• DOI: 10.1007/s11682-020-00399-z
• 发表时间: 2021-08
• 期刊: Brain imaging and behavior
• 影响因子: 3.2
• 作者: Koenig KA;Bekris LM;Ruedrich S;Weber GE;Khrestian M;Oh SH;Kim S;Wang ZI;Leverenz JB
• 通讯作者: Leverenz JB

Harnessing endophenotypes and network medicine for Alzheimer's drug repurposing.

• DOI: 10.1002/med.21709
• 发表时间: 2020-11
• 期刊: Medicinal research reviews
• 影响因子: 13.3
• 作者: Fang J;Pieper AA;Nussinov R;Lee G;Bekris L;Leverenz JB;Cummings J;Cheng F
• 通讯作者: Cheng F