Cleveland Alzheimer's Disease Research Center

克利夫兰阿尔茨海默病研究中心

• 批准号: 10170038
• 负责人: JAMES Bruce LEVERENZ
• 金额: $ 36.86万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10170038
• 关键词: Affect; Alzheimer' s Disease; Alzheimer' s disease related dementia; Clinic; Clinical; Clinical Research; Cognitive; Collection; Communities; Country; Databases; Dementia; Disease; Evaluation; Foundations; Funding; Health system; Healthcare; Heterogeneity; Image; Individual; Infrastructure; International; Lewy Body Dementia; Magnetic Resonance Imaging; Medical; Medical center; Minority Enrollment; National Institute on Aging; Nevada; Ohio; Participant; Pathologic; Pathology; Persons; Phenotype; Physicians; Population; Prion Diseases; Protocols documentation; Research; Research Personnel; Sampling; Science; Speed; Standardization; Structure; United States National Institutes of Health; Universities; University Hospitals; amyloid imaging; amyloid pathology; amyloid structure; improved; mild cognitive impairment; neuroimaging; programs; recruit

OVERALL PROJECT SUMMARY The Cleveland Alzheimer’s Disease Research Center (CADRC) is a collaborative effort amongst physicians and investigators from Case Western Reserve University (CWRU), the Cleveland Clinic Foundation (CCF), the Metro Health System (MHS), University Hospitals (UH), and the Louis Stokes Cleveland VA Medical Center (LSVA), to establish a National Institute on Aging (NIA) funded Alzheimer’s disease research center. The CADRC would represent a rich clinical and research community and an estimated 220,000 Ohioans who suffer from Alzheimer’s disease (AD). Currently there is no Alzheimer’s Disease Research Center in Ohio. The CADRC will bring together the considerable expertise from the medical and academic communities in northeast Ohio to focus on one of the largest health care crises facing our country. The CADRC will be focused on the increasingly recognized clinical and pathologic heterogeneity observed in AD and AD-Related Dementias (ADRD). The CADRC will create an infrastructure to help speed up the research efforts of local, national and international investigators. The CADRC will participate in the national Alzheimer’s Centers program and contribute to the “big science” possible when centers from around the country collaborate. We will recruit subject samples that northeast Ohio is well situated to study due to unique regional populations or studies (dementia with Lewy bodies and rapidly progressive AD identified by the National Prion Disease Pathology Surveillance Center,) or relevant to our understanding of AD and related dementias (cognitively normal older individuals, AD and mild cognitive impairment). We will add value to the evaluation of these subject samples by adding biofluid collection and analysis and cutting edge imaging. Special emphasis will also be placed on enrollment of minority populations not often well-studied. We are quite encouraged by the collaborative spirit already demonstrated by those participating in the CADRC planning from CWRU, CCF, MHS, UH, and LSVA and from the support we have received from the northeast Ohio community. We believe this is a great opportunity for Ohio to contribute to the greater efforts of the Alzheimer’s Disease Research Centers program and to improve the treatments for these devastating disorders.

全面的 项目摘要 克利夫兰阿尔茨海默氏病研究中心（CADRC）是一项合作的努力 医师和Case Western Resern Reserve University（CWRU），克利夫兰诊所基金会 （CCF），地铁卫生系统（MHS），大学医院（UH）和Louis Stokes Cleveland VA Medical 中心（LSVA），建立一个国家老化研究所（NIA）资助的阿尔茨海默氏病研究中心 CADRC将代表一个丰富的临床和研究社区，估计有22万 来自阿尔茨海默氏病（AD）。 CADRC将带来医学和学术社区的大量专业知识 在俄亥俄州东北部，将CADRC面对的最大的医疗保健护理之一。 在广告相关的痴呆症中观察到的含有浸润的临床和病理异质性 （ADRD）。 CADRC将创建一个基础设施，以帮助加快本地，国家和 国际调查人员。 当我们将招募主题时，为“大科学”做出了贡献。 俄亥俄州北部北部由于独立人群或研究的样本（痴呆症）（痴呆症） 由路易的身体和由国家病理病理病理学监测确定的迅速编程的进步广告 中心），或与我们对AD和相关痴呆症的理解有关 和轻度的认知障碍）。 收集和分析和最先进的成像也将放在少数群体上 流行音乐经常研究不经过充分研究。 参与的人证明了我们的协作性螺丝质的鼓舞 来自CWRU，CCF，MHS，UH和LSVA的CADRC计划，以及我们从您那里得到的支持。 俄亥俄州东北部社区。 阿尔茨海默氏病研究中心计划，以改善这些毁灭性的治疗方法 疾病。