DEVELOPMENT OF RABBIT MONOCLONAL ANTIBODIES FOR FERRET BIOMARKERS

雪貂生物标志物兔单克隆抗体的开发

• 批准号: 10470554
• 负责人: XIAOMIN FAN
• 金额: $ 35.6万
• 依托单位: AVANTGEN, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10470554
• 关键词: Address; Antibodies; Biological Assay; Biological Markers; Enzyme-Linked Immunosorbent Assay; Ferrets; IL8 gene; Immunization; Immunologics; Immunology procedure; Infectious Disease Immunology; Inflammatory; Interferon Type II; Interleukin-1; Interleukin-18; Measures; Monoclonal Antibodies; Oryctolagus cuniculus; Reagent; Research; TNF gene; Yeasts; cytokine; immune activation; infectious disease model; receptor; response

This project is to generate and characterize rabbit monoclonal antibodies (mAbs) against five ferret biomarkers, focusing on inflammatory cytokines produced following immune activation in ferrets. Generated mAbs will undergo extensive immunological characterization. The successful completion of this project will address an urgent need for specific and sensitive reagents capable of measuring cytokine responses in the ferret model for infectious disease and immunology research.

该项目是为了产生和表征针对五种雪貂生物标志物的兔单克隆抗体（mAb），重点是在雪貂中免疫激活后产生的炎性细胞因子。产生的mAB将经历广泛的免疫学表征。该项目的成功完成将迫切需要对能够在传染病和免疫学研究的雪貂模型中测量细胞因子反应的特定和敏感试剂。