Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk

体力活动、久坐行为和静脉血栓栓塞风险

• 批准号: 10461777
• 负责人: Laura Brienne Harrington
• 金额: $ 17.77万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-19 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10461777
• 关键词: Accelerometer; Aging; Area; Behavior; Biological Markers; Blood coagulation; Cardiac rehabilitation; Cardiovascular Diseases; Cardiovascular system; Clinical; Complex; Cross-Over Studies; Data; Data Collection; Deep Vein Thrombosis; Doctor of Philosophy; Elderly; Epidemiologist; Epidemiology; Evaluation; Event; Female; Fibrin fragment D; Future; Generations; Goals; Guidelines; Hemostatic Agents; Hemostatic function; Hour; Incidence; Individual; Life Style; Malignant Neoplasms; Measures; Methodology; Nested Case-Control Study; Nurses' Health Study; Obesity; Outcome; Patient Self-Report; Persons; Physical activity; Population; Prognosis; Public Health; Publishing; Pulmonary Embolism; Recommendation; Reporting; Research; Research Design; Risk; Risk Factors; Scientist; Secondary Prevention; Strenuous Exercise; Survivors; Thrombin; Training; Triad Acrylic Resin; United States; Venous; Woman; Women' s Health; Work; activated Protein C; adverse outcome; base; cardiovascular risk factor; career; cohort; design; epidemiology study; improved; innovation; male; moderate-to-vigorous physical activity; modifiable risk; mortality; public health relevance; sedentary lifestyle; thrombotic; translational potential; venous thromboembolism

Abstract: Venous thromboembolism (VTE) is the third most common cardiovascular disease in the United States. Venous stasis, which can occur during prolonged periods of inactivity, is a known risk factor for VTE; however, the relationship between physical activity and VTE is inconsistent and guidance regarding physical activity after a VTE is lacking. The overarching goal of the proposed scientific aims is to further our understanding of the associations of physical activity and sedentary behavior in relation to: (1) incident VTE risk, (2) short-term VTE risk following physical activity, (3) long-term prognosis following an incident VTE, and (4) hemostatic factor levels, which are associated with thrombotic event risk. This study will leverage existing data from the robust Women’s Health Initiative and the Nurses’ Health Studies I and II cohorts in addition to newly collecting data in the setting of a case-crossover study. Innovative aspects of the proposed work include the evaluation of accelerometer-measured physical activity and sedentary behavior in relation to VTE risk, the evaluation of VTE risk following physical activity using case-crossover methodology, the evaluation of physical activity and sedentary behavior with long-term prognosis among VTE survivors, and the evaluation of usual physical activity in relation to hemostatic parameter measures. Not only are the proposed scientific aims of

抽象的： 静脉血栓栓塞（VTE）是美国第三大常见的心血管疾病。 静脉暂停可能在长时间的无活动时期发生，是VTE的已知危险因素。然而， 体育锻炼与VTE之间的关系是不一致的，并且在 缺少VTE。拟议的科学目的的总体目标是进一步了解我们对 与：（1）事件风险，（2）短期VTE相关的体育活动和久坐行为的关联 体育活动后的风险，（3）事件后的长期预后和（4）止血因素 水平，与血栓事件风险有关。这项研究将利用可靠的现有数据 妇女的健康计划和护士健康研究I和II同伙除了新收集数据外 案例交叉研究的设置。拟议工作的创新方面包括评估 加速度计测量与VTE风险有关的体育活动和久坐行为，VTE的评估 体育锻炼后使用案例交叉方法，体育活动评估和 VTE冲浪者之间具有长期预后的久坐行为，并评估通常 与止血参数测量有关的活性。不仅提议的科学目标

项目成果

Increased COVID-19 Infection Risk Drives Racial and Ethnic Disparities in Severe COVID-19 Outcomes.

• DOI: 10.1007/s40615-021-01205-2
• 发表时间: 2023-03
• 期刊: Journal of racial and ethnic health disparities
• 影响因子: 3.9
• 作者: Shortreed SM;Gray R;Akosile MA;Walker RL;Fuller S;Temposky L;Fortmann SP;Albertson-Junkans L;Floyd JS;Bayliss EA;Harrington LB;Lee MH;Dublin S
• 通讯作者: Dublin S

Comparative venous thromboembolic safety of oral and transdermal postmenopausal hormone therapies among women Veterans.

• DOI: 10.1097/gme.0000000000001823
• 发表时间: 2021-07-26
• 期刊: Menopause (New York, N.Y.)
• 作者: Blondon M;Timmons AK;Baraff AJ;Floyd JS;Harrington LB;Korpak AM;Smith NL
• 通讯作者: Smith NL