Predictors of Reactivity to Physical Activity Measurement among Women in Midlife with Elevated CVD Risk: Examination Across 7 Studies

CVD 风险升高的中年女性体力活动测量反应的预测因素：7 项研究的检查

基本信息

批准号：
10768082
负责人：
Danielle Arigo
金额：
$ 14.85万
依托单位：
ROWAN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10768082
关键词：
Accelerometer Address Adult Affect Age Aging Area Attention Award Behavior Biological Body mass index Cardiovascular system Characteristics Child Clinical Trials Complement Data Set Data Sources Enrollment Evaluation Funding Future Gender Goals Hypertension Individual Differences Intervention Life Light Exercise Longevity Masks Measurement Medical Menopause Modeling Monitor Obesity Outcome Participant Pattern Physical activity Physical assessment Physiological Population Populations at Risk Procedures Process Public Health Recommendation Research Research Activity Research Design Risk Sampling Source Subgroup Techniques Testing Time United States National Institutes of Health Vulnerable Populations Woman Work age group biological sex cardiovascular disorder risk data handling depressive symptoms design exercise intervention experience falls gender difference gender disparity men middle age monitoring device multilevel analysis psychologic psychosocial public database response risk mitigation sedentary lifestyle sex social study characteristics tool vigorous intensity wearable device young adult

项目摘要

ABSTRACT Risk for cardiovascular disease (CVD) substantially increases during midlife (ages 40-60) and risk trajectories differ for women and men. Increasing physical activity (PA) can mitigate these risks and there is a critical need for research that can reduce barriers to engagement in this population. PA measurement reactivity, or a change in PA engagement in response to the introduction of PA measurement, may bias the objective assessment of PA that is essential to evaluating PA promotion efforts. At present, however, evidence supporting PA measurement reactivity as a key confound in PA research is mixed, including preliminary evidence from the investigative team. Our funded R03 is designed to address key limitations of existing work – including emphasis on children or healthy, young adults with low risk for CVD and lack of attention to individual differences between participants – among women in midlife with elevated CVD risk (e.g., obesity, hypertension; N = 800). The proposed supplement is designed to further address limitations of low power for conducting critical tests of gender differences in PA measurement reactivity responses, by including men and conducting the first fully powered test of gender differences in this area. We will use 6 existing datasets from NIH-funded clinical trials and publicly available databases to examine gender differences in PA measurement reactivity among midlife adults with elevated CVD risk (N = 1940). Using a coordinated analysis approach, we will employ multilevel modeling techniques to achieve the following aims: (1) To characterize midlife adults’ PA measurement reactivity across 4 PA outcomes (full sample and within genders): steps, minutes of light activity, minutes of moderate-to-vigorous intensity activity, and minutes of sedentary behavior, (2) To determine whether the presence or extent of measurement reactivity differ based on demographic, medical, or psychological characteristics (with emphasis on gender), and (3) To determine whether the presence or extent of measurement reactivity differ based on study characteristics such as research design (i.e., observation only vs. PA observation prior to the start of an intervention) and PA monitoring procedures (i.e., research-grade accelerometers vs. commercially available wearables). We will also examine whether gender moderates the influence of characteristics such as study design, BMI, or depressive symptoms. This work will identify circumstances associated with problematic levels of PA measurement reactivity among adults in midlife and potential gender-specific targets for reducing it in an at-risk group. This R03 supplement thus represents an important extension of funded work that leverages existing data sources to increase the scientific rigor of research in the fields of PA measurement and intervention, and to provide high-quality evidence that speaks to potential gender differences in PA measurement reactivity responses.

抽象的中年时期（40-60 岁）心血管疾病 (CVD) 的风险大幅增加，并且风险女性和男性的轨迹有所不同，增加体力活动 (PA) 可以减轻这些风险，并且迫切需要开展研究来减少这一人群参与 PA 的障碍。测量反应性，或 PA 参与度因 PA 引入而发生的变化测量，可能会导致对 PA 的客观评估产生偏差，而这对于评估 PA 推广至关重要然而，目前支持 PA 测量反应性的努力是 PA 中的一个关键问题研究结果好坏参半，包括我们资助的 R03 的初步证据。旨在解决现有工作的主要局限性——包括强调儿童或健康、年轻的人心血管疾病风险低且缺乏对参与者之间个体差异的关注的成年人 CVD 风险较高的中年女性（例如肥胖、高血压；N = 800）。补充旨在进一步限制解决进行关键性别测试的低权力问题 PA 测量反应性反应的差异，通过包括男性并进行第一次全面我们将使用 NIH 资助的临床的 6 个现有数据集进行性别差异的有力测试。用于检查 PA 测量反应性性别差异的试验和公开数据库在 CVD 风险较高的中年成年人中（N = 1940），我们将使用协调分析方法。采用多层次建模技术来实现以下目标：（1）描述中年成年人的特征跨 4 个 PA 结果的 PA 测量反应性（完整样本和性别内）：步骤、分钟轻度活动、中等至剧烈强度活动的分钟数以及久坐行为的分钟数，(2) 为了确定测量反应性的存在或程度是否因人口统计而不同，医学或心理特征（重点是性别），以及 (3) 确定是否基于研究特征（例如研究）的测量重差异活动的存在或程度设计（即仅观察与干预开始前的 PA 观察）和 PA 监测程序（即研究级加速度计与商用可穿戴设备）。检查性别是否会调节研究设计、BMI 或其他特征的影响这项工作将确定与 PA 水平有问题相关的情况。测量中年成年人的反应性以及减少特定性别的潜在目标因此，这个 R03 补充代表了受资助工作的重要延伸。利用现有数据源增加 PA 领域的科学研究测量和干预，并提供说明潜在性别的高质量证据 PA 测量反应性响应的差异。