Administrative Supplement to Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk

对体力活动、久坐行为和静脉血栓栓塞风险的行政补充

基本信息

批准号：
10273740
负责人：
Laura Brienne Harrington
金额：
$ 5.34万
依托单位：
KAISER FOUNDATION RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-19 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10273740
关键词：
Accelerometer Administrative Supplement Aging Area Biological Markers Blood coagulation Cardiac rehabilitation Cardiovascular Diseases Cardiovascular system Clinical Complex Cross-Over Studies Data Data Collection Deep Vein Thrombosis Doctor of Philosophy Elderly Epidemiologist Epidemiology Evaluation Event Female Fibrin fragment D Funding Future Generations Goals Guidelines Hemostatic Agents Hemostatic function Hour Incidence Individual K-Series Research Career Programs Life Life Style Malignant Neoplasms Measures Mentored Research Scientist Development Award Mentors Methodology Morbidity - disease rate National Heart, Lung, and Blood Institute Nested Case-Control Study Nurses&apos Health Study Obesity Outcome Parents Patient Self-Report Persons Physical activity Population Prognosis Public Health Publishing Pulmonary Embolism Recommendation Reporting Research Research Design Risk Risk Factors Scientist Secondary Prevention Strenuous Exercise Survivors Thrombin Training Triad Acrylic Resin United States United States National Institutes of Health Venous Woman Women&apos s Health Work activated Protein C adverse outcome base cardiovascular risk factor career career development cohort design epidemiology study improved innovation male moderate-to-vigorous physical activity modifiable risk mortality public health relevance sedentary lifestyle thrombotic venous thromboembolism

项目摘要

Summary Venous thromboembolism (VTE) is the third most common cardiovascular disease in the United States. Venous stasis, which can occur during prolonged periods of inactivity, is a known risk factor for VTE; however, the relationship between physical activity and VTE is inconsistent and guidance regarding physical activity after a VTE is lacking. The overarching goal of this proposed “Administrative Supplement for Continuity and Retention of NIH Mentored Career Development (K) Award Recipients and Scholars” is to provide supplemental support of the scientific and training aims of the NHLBI-funded K01, “Physical Activity, Sedentary Behavior, and Venous Thromboembolism Risk”, following a life event. Dr. Laura B. Harrington's ongoing parent K01 award aims to further our understanding of physical activity and sedentary behavior in relation to: (1) incident VTE risk, (2) short-term VTE risk following physical activity, (3) long-term prognosis following an incident VTE, and (4) hemostatic factor levels, which are associated with thrombotic event risk. This study leverages existing data from the Women's Health Initiative and the Nurses' Health Studies I and II cohorts in addition to newly collecting data in the setting of a case-crossover study. Innovative aspects of the proposed work include the evaluation of accelerometer-measured physical activity and sedentary behavior in relation to VTE risk, the evaluation of VTE risk following physical activity using case-crossover methodology, the evaluation of physical activity and sedentary behavior with long-term prognosis among VTE survivors, and the evaluation of usual physical activity in relation to hemostatic parameter measures. Not only are the proposed scientific aims of

概括静脉血栓栓塞（VTE）是美国第三大常见的心血管疾病。静脉暂停可能在长时间的无活动时期发生，是VTE的已知危险因素。然而，体育锻炼与VTE之间的关系是不一致的，并且在缺少VTE。该拟议的“连续性的行政补充和保留NIH指导职业发展（K）奖的获奖者和学者”是为了提供 NHLBI资助的K01的科学和培训目标的补充支持，“体育活动，久坐在生活事件之后，行为和静脉血栓栓塞风险。劳拉·B·哈灵顿（Laura B. K01奖的目的是进一步了解以下方面的体育活动和久坐行为。（1）事件VTE风险，（2）体育活动后短期VTE风险，（3）入射VTE和（4）与血栓事件风险相关的止血因子水平。这项研究利用妇女健康计划和护士健康研究I和II同伙的现有数据除了在一项案例分解研究的设置中新收集数据。拟议的创新方面工作包括评估加速度计的体育活动和久坐行为 VTE风险，使用案例 - 分裂方法的体育活动后对VTE风险的评估，评估体育锻炼和久坐行为，并在VTE表面之间进行长期预后，以及评估与止血参数测量有关的常规体育活动。不仅提议科学目标