Boston Roybal Center for Active Lifestyle Interventions

波士顿皇家积极生活方式干预中心

• 批准号: 10463573
• 负责人: MARGIE E LACHMAN
• 金额: $ 55.42万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463573
• 关键词: Address; Adopted; Adult; Aging; Area; Behavior; Behavior Therapy; Behavioral; Boston; Characteristics; Clinical Trials; Cognitive; Collaborations; Common Core; Communities; Community Practice; Complex; Data; Development; Effectiveness; Elderly; Electric Stimulation; Exercise; Faculty; Feeling; Funding; Future; Goals; Grant; Guidelines; Health; Health Benefit; Health Promotion; Health Services; Human; Human Resources; Independent Living; Individual; Informal Social Control; Institution; Interdisciplinary Study; Intervention; Intervention Studies; Lead; Life; Link; Low income; Maintenance; Measures; Mediator of activation protein; Medical Care Costs; Minority; Modeling; Monitor; Motivation; Outcome; Pattern; Personal Satisfaction; Persons; Physical activity; Pilot Projects; Process; Productivity; Psyche structure; Publications; Quality of life; Research; Research Personnel; Resources; Risk; Self Efficacy; Solid; Source; Techniques; Testing; Translating; Translations; United States National Institutes of Health; Universities; Update; Vulnerable Populations; Work; active lifestyle; base; behavior change; behavior measurement; behavior test; college; community organizations; community setting; design; disability; efficacy evaluation; evidence base; executive function; experience; healthy aging; high risk; imaging modality; improved; innovation; lifestyle intervention; medical schools; meetings; member; middle age; neuromechanism; novel; personalized approach; pilot test; prevent; programs; psychologic; psychosocial; relating to nervous system; sedentary; sedentary lifestyle; social; social engagement; therapy design

The overall goal of the Boston Roybal Center for Active Lifestyle Interventions (RALI Boston) is to develop and test behavior change strategies to promote healthy aging, especially among sedentary adults and others at high risk for poor health outcomes. It is widely known that physical activity is broadly beneficial for physical, psychological, and cognitive aspects of health. However, the number of middle-aged and older adults who are regularly active remains quite low. This RALI Boston renewal application focuses on theme #2 from the RFA: “Physical activity promotion to create, modify and pilot test principle-based interventions to reduce sedentary behavior and increase physical activity.” The specific aims of the project are to: 1) conduct innovative clinical trials based on solid research evidence and using the NIH Stage Model that can be translated to increase physical activity in middle-aged and older adults as a means to healthy aging, 2) advance research on behavior change processes in intervention research by identifying and testing the mechanisms that lead to increases in physical activity and improved health and well-being, 3) provide the necessary scientific expertise and resources to facilitate innovative interdisciplinary research and translation by leading and coordinating projects across five universities and community organizations. These aims will be accomplished through two cores, the Management and Administration Core and the Pilot Core. We will develop novel behavior change strategies, evaluate how they work in clinical trials with different vulnerable populations, and assess whether they lead to sustained changes in physical activity, using well-validated measures that are available to investigators in our RALI Toolbox. Ultimately, we will use the information gained to refine the techniques and update our conceptual framework, and will develop and test full scale translational interventions designed to improve activity, health and quality of life among middle-aged and older adults. The Center is distinguished by a number of innovative features: It 1) recognizes the multiple influences on human behavior that interact in complex ways and applies a unique multi-component model of behavior change; 2) uses a personalized approach and adapts the proposed interventions according to the individual characteristics and contextual circumstances of the person; 3) expands our focus to include basic neural mechanisms and other mediators of behavior change by employing novel imaging methods and noninvasive electrical stimulation; 4) focuses on underserved, vulnerable populations of middle-aged and elderly adults at risk for poor health outcomes and partners with community organizations serving diverse middle-aged and older adults who will benefit from the Center activities; 5) uses a common core of behavioral measures that will enable us to compare results of different pilot study interventions; 6) has successfully engaged a committed, interdisciplinary team of senior investigators who bring multiple professional perspectives and extensive resources from five universities: Brandeis U, Boston U., Boston College, Northeastern U., Harvard Medical School/Hebrew Senior Life.

波士顿皇家积极生活方式干预中心（Rali Boston）的总体目标是发展和 测试行为改变策略以促进健康的衰老，尤其是在久坐的成年人和其他人中 健康结果不良的高风险。众所周知，体育锻炼对物理，广泛有益 健康的心理和认知方面。但是，中年和老年人的数量 通常，主动仍然很低。此Rali Boston Renewal应用程序的重点是RFA的主题2： “促进体育锻炼以创建，修改和试点测试原理干预措施，以减少久坐的 行为并增加体育锻炼。”该项目的具体目的是：1）进行创新的临床 基于可靠的研究证据和使用NIH阶段模型的试验，可以翻译以增加 中年和老年人的体育锻炼作为健康衰老的一种手段，2）提前研究 通过识别和测试导致的机制，在干预研究中的行为改变过程 体育锻炼的增加并改善了健康和福祉，3）提供必要的科学专业知识 以及通过领导和协调的创新跨学科研究和翻译的资源 五个大学和社区组织的项目。这些目标将通过两个 核心，管理和管理核心以及飞行员核心。我们将发展新颖的行为改变 策略，评估它们如何在不同脆弱人群的临床试验中工作，并评估是否 它们使用验证的措施可用于 我们的Rali工具箱中的调查人员。最终，我们将使用获得的信息来完善这些技术和 更新我们的概念框架，并将开发和测试全面的翻译干预措施 改善中年和老年人的活动，健康和生活质量。中心有区别 许多创新的特征：1）认识到对人类行为的多种影响 复杂的方式并应用了行为改变的独特多组分模型； 2）使用个性化 方法并根据个人特征和上下文调整所提出的干预措施 人的情况； 3）将我们的重点扩大到包括基本的神经机制和其他调解人 通过采用新型成像方法和无创的电刺激来改变行为； 4）专注于 服务不足，脆弱的中年和古老的成年人的健康状况不佳的风险 与为潜水员中年和老年人服务的社区组织的合作伙伴，他们将从中受益 中心活动； 5）使用行为措施的共同核心，使我们能够比较 不同的试点研究干预措施； 6）成功地聘请了一支坚定的跨学科团队 从五所大学带来多种专业观点和广泛资源的调查人员： Brandeis U，波士顿U.，波士顿学院，美国东北部，哈佛医学院/希伯来语高级生活。