Boston Roybal Center for Active Lifestyle Interventions

波士顿皇家积极生活方式干预中心

• 批准号: 10657679
• 负责人: MARGIE E LACHMAN
• 金额: $ 38.91万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657679
• 关键词: Adherence; Adult; Advisory Committees; Aging; Ancillary Study; Applications Grants; Area; Basic Science; Behavior Therapy; Behavioral; Behavioral Mechanisms; Boston; Clinical Trials; Cognitive; Collaborations; Control Groups; Data; Development; Discipline; Disease; Elderly; Emotional; Ensure; Ethnic Origin; Faculty; Foundations; Funding; Future; Goals; Grant; Health; Health Promotion; Individual; Institution; Intervention; Knowledge; Left; Link; Maintenance; Measures; Mentors; Methods; Modeling; Monitor; Motivation; Outcome; Personal Satisfaction; Persons; Phase; Physical activity; Pilot Projects; Population; Populations at Risk; Postdoctoral Fellow; Prefrontal Cortex; Procedures; Process; Protocols documentation; Psychosocial Factor; Race; Randomized, Controlled Trials; Reproducibility; Research; Research Methodology; Research Personnel; Resources; Safety; Science; Testing; Time; Translating; Translations; United States Department of Veterans Affairs; United States National Institutes of Health; Vulnerable Populations; Work; Writing; active lifestyle; behavior change; behavior test; design; doctoral student; efficacy evaluation; evidence base; executive function; experience; experimental study; feasibility testing; healthy aging; high risk; human subject; improved; innovation; knowledge base; lifestyle intervention; meetings; middle age; novel; physical inactivity; pilot trial; poor health outcome; psychosocial; sedentary; social; success; tool; transcranial direct current stimulation; translational goal

Project Summary: The Pilot Core B will support one of the principle mechanisms by which the Boston Roybal Center for Active Lifestyle Interventions (RALI Boston) will address its overarching goal to develop and test behavior change strategies that increase physical activity and promote healthy aging, especially for persons at high risk for poor health outcomes. The Pilot Core will achieve this goal by supporting a group of innovative and scientifically rigorous clinical trials by pilot investigators who will enhance our knowledge base, develop novel research methodologies and tools, disseminate our results, and ultimately work collaboratively to develop the pilot data and experience necessary to conduct future full-scale translational interventions using clinical trials. The specific aims of the Core are: 1) to solicit, select, and support two to three of the most meritorious pilot studies submitted to us each year to develop and test novel multicomponent strategies to promote behavioral changes that advance the science and result in improved health and well-being for older people; 2) to oversee and support the progress of pilot investigators and their projects and provide resources to assure their success in testing the feasibility, acceptability and efficacy of behavioral interventions guided by the NIH Stage Model; 3) to apply the research findings from the pilot projects to design translational projects and work with investigators to seek additional funding to develop and test them at different phases of the NIH Stage Model; 4) to implement procedures to assure the scientific integrity, rigor and reproducibility of our research and the safety of human subjects. The Pilot Core Leaders (Drs. Margie Lachman, Lewis Lipsitz and Theresa Ellis) will work closely with the Management and Administrative Core to ensure the Center operates smoothly and fulfills its aims. Procedures are in place to solicit, review and support new pilot projects. The pilot projects will draw on the most promising recent evidence linking psychosocial, behavioral, cognitive, and neuroscientific factors to health and to explore mechanisms involved in motivation and behavior change. Two pilot studies are proposed for the initial period of this renewal application to examine the efficacy of enhancing both motivation and executive control, two processes that have shown promise in engendering increased physical activity in sedentary individuals. One pilot is a randomized controlled trial that will test the feasibility and effects of a 10- session transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on adherence to a personalized physical activity goal in physically-inactive older adults without overt illness or disease. The second pilot will examine the effects of two psychosocial factors, positive messaging and self-affirmation, on motivation and engagement in physical activity and their maintenance over time, compared to a control group that receives only positive messaging. Results of these studies will be used to develop new interventions for testing in larger scale clinical trials. The pilot core will continue to oversee the development of novel pilot studies and the translation and dissemination of findings from the Center.

项目摘要：飞行员核心B将支持波士顿皇家的主要机制之一 主动生活方式干预中心（Rali Boston）将解决其开发和测试的总体目标 行为改变策略，以增加体育锻炼并促进健康的衰老，尤其是对于 健康结果不良的高风险。飞行员核心将通过支持一系列创新来实现这一目标 试点调查人员将进行科学严格的临床试验，他们将增强我们的知识基础，发展 新颖的研究方法和工具，传播我们的结果，并最终合作 制定试点数据和经验，以进行未来的全面翻译干预措施 临床试验。核心的具体目的是：1）征求，选择和支持最多的两到三个 每年提交给我们的有功试验研究，以制定和测试新颖的多组分策略 促进行为变化，可以推进科学并改善老年人的健康和福祉 人们; 2）监督和支持试点调查人员及其项目的进度并提供资源 确保他们成功地测试行为干预措施的可行性，可接受性和功效 NIH舞台模型； 3）将试点项目的研究结果应用于设计翻译项目和 与调查人员合作寻求额外的资金来开发和测试NIH阶段的不同阶段 模型; 4）实施程序以确保我们的研究的科学完整性，严格性和可重复性以及 人类受试者的安全。飞行员核心领导者（Margie Lachman博士，Lewis Lipsitz和Theresa Ellis） 将与管理层和行政核心紧密合作，以确保中心运行顺畅，并且 实现其目标。已经制定了征求，审查和支持新试点项目的程序。飞行员项目将 利用与社会心理，行为，认知和神经科学有关的最有前途的证据 健康的因素并探索涉及动机和行为改变的机制。两个试点研究是 提议在此更新应用的最初时期，以检查增强这两种动机的功效 和执行控制，这两个过程表现出有望提高体育锻炼的希望 久坐的人。一个飞行员是一项随机对照试验，将测试10-的可行性和影响 会话经颅直流刺激（TDCS）靶向左侧外侧前额叶的干预措施 在没有公开的身体不活跃的老年人中遵守个性化体育锻炼目标的皮层 疾病或疾病。第二个飞行员将检查两个社会心理因素的影响，即积极的消息传递 以及自我肯定，随着时间的推移的动力和参与体育锻炼及其维护， 与仅接收正消息传递的对照组相比。这些研究的结果将用于 在大规模临床试验中开发新的干预措施。飞行员核心将继续监督 新型试点研究的发展以及中心发现的翻译和传播。