FASEB SRC: Structure and Function of Small GTPases

FASEB SRC：小 GTP 酶的结构和功能

• 批准号: 10463260
• 负责人: MARK Reid PHILIPS
• 金额: $ 0.35万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463260
• 关键词: Academy; Achievement; Adhesions; Anniversary; Antineoplastic Agents; Automobile Driving; Award; Binding; Biochemical; Cancer Biology; Cell division; Cell physiology; Clinic; Collaborations; Communities; Cytoskeleton; Development; Drug Design; Educational workshop; Environment; Environment Design; Family; Financial Support; Fostering; Funding; Future; G-Protein-Coupled Receptors; GTP Binding; Gene Expression; Genes; Goals; Growth Factor Receptors; Guanine Nucleotides; Guanosine Triphosphate Phosphohydrolases; Health; Heterotrimeric GTP-Binding Proteins; Human; Human Genome; Industry; Integrins; International; Knowledge; Malignant Neoplasms; Mediating; Metabolism; Mitosis; Molecular; Monomeric GTP-Binding Proteins; Mutate; Neoplasm Metastasis; Nuclear Import; Oncogenes; Oncology; Phagocytosis; Play; Protein Family; Proteins; RAS genes; Request for Applications; Research; Research Personnel; Rivers; Role; Science; Scientific Advances and Accomplishments; Scientist; Senior Scientist; Signal Pathway; Signal Transduction; Structure; Syndrome; Technology; Therapeutic; Time; Training; Transistors; Translating; Travel; Underrepresented Minority; Underrepresented Populations; Vermont; Woman; career development; cell growth; cell motility; design; driving force; drug discovery; falls; gene product; guanine nucleotide binding protein; infancy; interest; lectures; meetings; member; metaplastic cell transformation; novel therapeutics; posters; preference; programs; rac1 GTP-Binding Protein; ran GTP-Binding Protein; ras Oncogene; ras Proteins; receptor; recruit; social; summer research; symposium; targeted cancer therapy; tumor growth; tumorigenesis; vesicle transport; virtual

Summary Rational drug design for cancer requires a thorough understanding of signaling networks in order to reveal nodes that can be targeted. Small GTPases are central components of numerous signaling pathway, including many that drive oncogenesis and metastasis. Small GTPases are binary switches that are interconverted from the GDP-bound off to the GTP-bound on state by receptors and regulatory molecules and, when in the on state, drive signaling through various effector molecules. The superfamily of small GTPases number more than 160 gene products and can be divided into five families: RAS, RHO, RAB, ARF and RAN proteins. RAS proteins were the first small GTPases identified and remain the best studied. RAS genes are the oncogenes more frequently mutated in cancer than any other, which accounts for the intense interest in understanding and targeting these GTPases. The FASEB Summer Research Conference on Small GTPases was founded in 1991 and has been held every two years since. The conference has consistently attracted the leaders in the field and has played a large role in driving the field forward and promoting collaborations that have expedited discoveries that have been translated into drug discovery. The conference has also served as a platform for encouraging young investigators to enter the field. This application seeks partial funding for the 30th Anniversary Meeting of the FASEB SRC on the Structure and Function of Small GTPases. The meeting will feature a keynote lecture by Channing Der, one of the co-founders of the meeting who remains a driving force in the field. Also featured will be 28 plenary talks. Fifty percent of the invited speakers are new to the conference and are intended to bring fresh ideas and technologies. Twenty short talks will be selected from submitted abstracts and delivered by young scientists. All attendees will present posters. Opportunities for informal discussions and for networking will abound over the 5-day meeting that will include unscheduled time in the afternoons as well as a Meet-the- Expert lunch and a Career Development breakfast. Forty-three percent of invited speakers are woman. A concerted effort is planned to recruit trainees who are members of underrepresented groups. Ten travel/registration awards will be made to trainees with preference given to underrepresented minorities.

概括 癌症的理性药物设计需要对信号网络有透彻的了解才能揭示节点 可以针对目标。小GTPases是许多信号通路的中心组件，包括许多信号通路 那驱动肿瘤发生和转移。小GTPases是二进制开关，与 通过受体和调节分子在状态下，GDP绑定到GTP的状态，在状态下， 通过各种效应分子驱动信号。小型GTPases的超家族数量超过160 基因产物，可以分为五个家庭：RAS，RHO，RAB，ARF和RAN蛋白质。 RAS蛋白 是确定的第一个小型GTPases，并且仍然是最好的研究。 RAS基因更多 经常在癌症中突变的比其他任何人都对理解和 针对这些GTPases。 FASEB夏季小型GTPases研究会议成立于1991年 从那以后每两年举行一次。会议一直吸引了该领域的领导人， 在推动领域前进和促进合作的合作方面发挥了重要作用 已转化为药物发现。该会议也是鼓励的平台 年轻的调查人员进入该领域。该申请为30周年会议寻求部分资金 FASEB SRC在小GTPase的结构和功能上的。会议将举办主题演讲 由Channing Der撰写，是会议的共同创始人之一，他仍然是该领域的驱动力。也有特色 将是28个全体会谈。邀请发言人中有50％是会议的新手，旨在带来 新鲜的想法和技术。将从提交的摘要中选出二十个简短的会谈，并由 年轻科学家。所有与会者都会呈现海报。非正式讨论和网络的机会 将在为期5天的会议中比比皆是，其中包括下午的时间外时间以及会议 - 专家午餐和职业发展早餐。 43％的受邀演讲者是女性。一个 计划为招募人数不足的群体成员的招募训练。十 将向受训者颁发旅行/注册奖，因为他们偏爱代表性不足的少数群体。