Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD)

阿巴拉契亚肥胖相关疾病细胞运输中心 (ACCORD)

基本信息

批准号：
10460401
负责人：
Uma Sundaram
金额：
$ 166.77万
依托单位：
MARSHALL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-15 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10460401
关键词：
Accountability Address Advisory Committees Appalachian Region Attention Biomedical Research Biometry Budgets Cellular Transport Alteration Centers of Research Excellence Clinical Sciences Collaborations Core Facility Country Development Disease Epidemic Evaluation Faculty Fostering Funding Funding Opportunities Future Future Generations Genomics Goals Grant Growth Health Heart Home Human Resources Image Individual Infrastructure Institution Investments Lead Learning Manuscripts Mentors Modeling Molecular Obesity Obesity associated disease Outcome Phase Physiology Plant Roots Policies Positioning Attribute Procedures Program Evaluation Publications Research Research Design Research Personnel Research Project Grants Research Support Resources Schools Scientist Time Time Management TimeLine Training Translating Translational Research United States United States National Institutes of Health Universities West Virginia Workforce Development biomedical scientist career development career networking cell growth regulation graduate student health care disparity health disparity innovation interest medical schools meetings member multidisciplinary next generation novel novel therapeutics obesity prevention operation student training symposium training opportunity undergraduate student

项目摘要

There is strong junior investigator interest and senior investigator expertise in cellular transport physiology at Marshall University's School of Medicine (MUSOM). Many of the innumerable health disparities of West Virginia/Central Appalachia (WV/CA) have their roots in widespread obesity, which is epidemic in the region. At the epicenter of these disparities, MUSOM is well positioned to address this. Thus, the overall goal of this new Center for Biomedical Research Excellence (COBRE) application is to promote cellular transport physiology research in obesity related diseases by the next generation of biomedical investigators and to enhance the necessary infrastructure to accomplish this at the MUSOM. The Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) will serve as the academic home for this COBRE. It will leverage existing resources such as the WV IDeA Network of Biomedical Research Excellence (WV-INBRE), excellent core facilities, and new institutional resources to train the junior investigators. Every COBRE project is hypothesis-driven; with each addressing a novel cellular transport alteration in a distinct obesity related condition, and each utilizing innovative complementary state of the art experimental approaches. A comprehensive and interactive mentoring plan with attention to the individualized needs of each junior investigator, and outstanding senior investigators as mentors, that is evaluation driven will train the junior investigators to become independent scientists. Novel hands-on mentoring and networking opportunities will further enhance the training of junior investigators. In order to sustain these many training opportunities, while addressing one of the most prevalent diseases, obesity, at the heart of many health disparities in WV/CA and nationwide, new resources (space, funding and faculty positions) have been committed to ACCORD by the institution. In turn, ACCORD, to enhance institutional cellular transport in obesity related disorders biomedical research capacity, will develop new resources as future Cores (e.g. Biostatistics and Study Design and Mentoring and Workforce Development preCores) and provide pilot funding. This ACCORD COBRE proposal is critical for WV/CA, as it focuses on a highly significant and extremely timely research problem. It is innovative because it studies cellular transport abnormalities in obesity related diseases, unique from any other COBRE. Thus, the novel projects of this COBRE will likely identify novel targets that can potentially be modeled as new therapeutics to ameliorate and/or prevent obesity related disorders not only in WV/CA, but across the country.

在细胞运输生理学方面有强大的初级研究员的兴趣和高级研究者专业知识马歇尔大学医学院（Musom）。西方的许多无数健康差异弗吉尼亚州/中央阿巴拉契亚（WV/CA）源于该地区流行病的广泛肥胖症。在这些差异的中心是穆斯姆（Musom）的好处，可以解决这个问题。因此，这个新的总体目标生物医学研究中心卓越（COBRE）的应用是促进细胞运输生理下一代生物医学研究者研究肥胖相关疾病的研究，并增强在Musom上实现这一目标的必要基础设施。阿巴拉契亚的蜂窝运输中心与肥胖有关的疾病（Accord）将成为该毛病的学术家园。它将利用现有资源，例如生物医学研究卓越的WV Idea网络（WV-INBRE），出色核心设施以及培训初级调查人员的新机构资源。每个毛绒项目都是假设驱动；每个人都解决了与肥胖相关的新细胞转运改变条件以及每个利用创新的互补状态的实验方法。一个全面互动的指导计划，并注意每个初级的个性化需求调查员和杰出的高级调查员作为导师，即评估驱动的将训练大三研究人员成为独立科学家。新颖的动手指导和网络机会将进一步增强了初级研究人员的培训。为了维持这些许多培训机会，而解决最普遍的疾病之一，肥胖，是WV/CA的许多健康差异的核心和全国范围机构。反过来，一致，以增强肥胖相关疾病中的机构细胞运输生物医学研究能力将作为未来核心发展新资源（例如生物统计学和研究设计和指导和劳动力开发前店）并提供试点资金。此协议田纳号提案对于WV/CA来说至关重要，因为它专注于一个非常重要且极其及时的研究问题。这是创新性是因为它研究了与肥胖相关疾病中的细胞转运异常鞋垫。因此，这种毛绒的新型项目可能会确定可能是可能是的新目标以新的治疗剂为模型来改善和/或预防肥胖相关疾病，不仅在WV/CA中，而且可以在全国范围内。