ACCORD Administrative Core

协议行政核心

• 批准号: 10460402
• 负责人: Uma Sundaram
• 金额: $ 64.95万
• 依托单位: MARSHALL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10460402
• 关键词: Advisory Committees; Affect; Appalachian Region; Biomedical Research; Biometry; Budgets; Centers of Research Excellence; Clinical Sciences; Collaborations; Country; Development; Developmental Disabilities; Disease; Dyslipidemias; Evaluation; Expenditure; Extramural Activities; Faculty; Foundations; Funding; Future Generations; Goals; Grant; Growth; Human Resources; Hypertension; Individual; Infrastructure; Institutes; Institution; Interdisciplinary Study; International; Kentucky; Manuscripts; Mentors; Mission; Molecular; Monitor; Morbidity - disease rate; Obesity; Obesity Epidemic; Outcome; Patient Care; Phase; Physiology; Policies; Positioning Attribute; Preparation; Primary Health Care; Procedures; Recommendation; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; Scientific Evaluation; Scourge; Supervision; Time; Training; Translating; Translational Research; Transport Process; United States National Institutes of Health; Universities; Vision; West Virginia; Workforce Development; base; career; career development; cell growth regulation; clinical center; faculty research; graduate student; health care disparity; improved; innovation; medical schools; meetings; mortality; next generation; programs; prospective; tumor; undergraduate student

The overall goal of the Administrative Core of the Center for Biomedical Research Excellence (COBRE) Appalachian Center for Cellular transport in Obesity Related Disorders (ACCORD) at the Marshall University School of Medicine (MUSOM) is to provide administrative oversight for the career development of ACCORD investigators as well as growth and sustainability of Center infrastructure. We envision the creation of a national center of excellence to promote cellular transport physiology in obesity related disorders at MUSOM, as this institution is at the epicenter of the obesity epidemic of this region. The emphasis of biomedical research will be on cellular and molecular transport abnormalities in obesity associated conditions such as dyslipidemia, hypertension, certain tumors and developmental disabilities. A comprehensive plan for administrative, fiscal, and scientific support will be established and implemented to assure appropriate supervision and direction of ACCORD. A robust plan for individual and group mentoring will be implemented as a foundational component of this COBRE. Mentoring will encompass all aspects of development of junior investigators including, but not limited to, management of lab finances and personnel, meeting individual time- framed research goals, preparation of manuscripts and presentations, development of extramural grants including R01 level funding proposals, and any additional individualized needs as identified. The expected outcome is successful acquisition of R01 NIH funding to sustain and build upon the research foundations that are already established. To further advance the research capacity, ACCORD will closely interact with existing resources (e.g., WV INBRE, UK/MU CTSA), and establish new programs. These will include 1. the Biostatistics and Study Design preCore and Mentoring and Workforce Development preCore that will be grown during phase I to become a full Cores in Phase II of this COBRE; and, 2. Pilot funding to enhance molecular and intracellular regulation of cellular transport in obesity related disorders. Finally, formative and summative evaluation of scientific integrity, progress, and accomplishments of ACCORD will be regularly conducted in a comprehensive manner. Based on results and advice of the Internal Advisory Committee (including its Executive Committee) and External Advisory Committee, appropriate corrective steps, as well as prospective steps to advance the mission of the ACCORD COBRE, will be regularly instituted. With this innovative and much needed Appalachian region program, we will train the next generation of investigators to conduct cellular transport research in obesity which contributes to much of the health care disparities not only in WV, but also in many other regions of this country.

生物医学研究中心卓越中心（COBRE）的行政核心的总体目标 马歇尔大学的肥胖相关疾病中的阿巴拉契亚蜂窝运输中心 医学院（Musom）将为协议的职业发展提供行政监督 研究人员以及中心基础设施的增长和可持续性。我们设想创建 国家卓越中心促进肥胖相关疾病中的细胞运输生理学， 由于该机构处于该地区肥胖症流行的中心。生物医学的重点 研究将针对肥胖相关条件中的细胞和分子转运异常，例如 血脂异常，高血压，某些肿瘤和发育障碍。一个全面的计划 将建立并实施行政，财政和科学支持，以确保适当 协定的监督和指导。将实施针对个人和小组指导的强大计划 作为此毛绒的基础组成部分。指导将涵盖初级发展的所有方面 调查人员包括但不限于实验室财务和人员的管理，满足个人时间 - 框架研究目标，手稿和演示的准备，开发壁外补助 包括R01级资金建议，以及确定的任何其他个性化需求。预期 结果是成功地收购了R01 NIH资金，以维持和建立研究基础， 已经建立。为了进一步提高研究能力，协定将与现有 资源（例如WV Inbre，UK/MU CTSA），并建立新计划。这些将包括1。生物统计学 并研究设计的精美设计，指导和劳动力发展预处 第一阶段成为该毛病的第二阶段的完整核心； 2。试点资金以增强分子和 肥胖相关疾病中细胞转运的细胞内调节。最后，形成性和总结性 评估科学完整性，进步和协定成就将定期进行 全面的方式。根据内部咨询委员会的结果和建议（包括 执行委员会）和外部咨询委员会，适当的纠正措施以及潜在的 将定期制定促进协议索布雷任务的步骤。具有这种创新和 急需的阿巴拉契亚地区计划，我们将训练下一代研究人员进行蜂窝 肥胖症的运输研究不仅在WV中，而且在 这个国家的许多其他地区。