HIV & Aging SWG

艾滋病病毒

• 批准号: 10458284
• 负责人: SURESH PALLIKKUTH
• 金额: $ 8.06万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458284
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Administrative Supplement; Advisory Committees; Affect; Age; Aging; Area; Award; Basic Science; Brain; COVID-19; COVID-19 pandemic; Cardiovascular Diseases; Cardiovascular system; Cells; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinics and Hospitals; Cognitive; Cognitive aging; Cohort Studies; Collaborations; Communities; Comprehensive Cancer Center; Data; Diabetes Mellitus; Evaluation; Florida; Focus Groups; Goals; HIV; HIV Infections; Health; Health Sciences; Immune; Immune System Diseases; Immune system; Immunity; Immunologics; Immunologist; Immunology; Impaired cognition; Individual; Infrastructure; Institutes; Institution; Interdisciplinary Study; Interest Group; Investigation; Joints; Knowledge; Lead; Life; Life Expectancy; Liver; Liver diseases; Malignant Neoplasms; Mental Health; Mentors; Metabolic; Microbiology; Monitor; Neurocognition; Neurocognitive; Neurocognitive Deficit; Neurologic; Neurologist; Personal Satisfaction; Persons; Population; Positioning Attribute; Process; Public Health; Publishing; Regulation; Reporting; Research; Research Institute; Research Personnel; Research Priority; Resources; Review Committee; Role; Science; Specific qualifier value; Strategic Planning; Talents; Translational Research; United States National Institutes of Health; Universities; Woman; acronyms; age related; aging population; antiretroviral therapy; brain health; cognitive neuroscience; community engagement; comorbidity; early onset; frailty; gut-brain axis; immunoregulation; innovation; interest; knowledge base; medical schools; meetings; multiple chronic conditions; neuroinflammation; programs; research study; response; symposium; virtual; working group

Project Summary/Abstract (HIV and Aging Scientific Working Group) The long-term objectives of the Miami-CFAR HIV and Aging Scientific Working Group (HA-SWG) are to promote innovative and emerging areas of research in HIV and aging through multidisciplinary collaborations. Since its inception in February 2019, the HA-SWG is actively involved in research on mechanisms that address the specific challenges that significantly impact our HIV-infected aging population in South Florida and beyond. Our studies include evaluation of HIV-related comorbidities and immune dysfunction and their influence on frailty and cognitive decline. The overall theme of multi-morbidity research serves to broaden the potential and scope of our SWG. In this application, we are presenting a significantly modified SWG that was developed with a focus on knowledge-based activities through the creation of working groups. These groups will study specific research areas utilizing innovative approaches. The topic of metabolic regulation of the immune system in aging is under- investigated and how HIV infection interacts with age-related metabolic reprogramming of immune cells and its implications on the earlier onset of immune dysfunction and comorbidities demands further investigation. Our current approach to understand the physical and cognitive frailty in aging persons living with HIV (PWH) has translational relevance. The HA-SWG will further expand the scope of research in this area by investigating the role of the gut-brain axis and liver-brain axis in the processes of neuroinflammation, accelerated neurocognitive decline and cognitive frailty in aging PWH. Here we propose two specific aims of the HA-SWG. First, to develop and promote innovative cross-disciplinary and collaborative translational research in the areas of immunology, metabolic regulation, neuroinflammation, frailty and cardiovascular/liver co-morbidities. Second, we will develop educational and mentoring activities within the University of Miami (UM) scientific community while enhancing the research goals specified in Aim 1. By achieving these aims, the HA-SWG endeavors to create a platform for interdisciplinary research at UM by bridging the clinical challenges of frailty, cognitive decline and comorbidities. These efforts will also support basic science research studying the mechanisms underlying metabolic regulation of immunity in HIV and Aging. The HA-SWG is also committed to create a resource-rich infrastructure to support cross-disciplinary proposals related to HIV and aging, support Early Stage Investigators and researchers new to the field of HIV research. To achieve our goals, the HA-SWG is uniquely positioned to leverage clinical and basic research resources and expertise available to the Miami-CFAR and infrastructure available at UM through the McKnight Brain Institute, Center on Neurocognitive Science and Aging, Comprehensive Center on Brain Health, Clinical and Translational Science Institute, Diabetes Research Institute, Schiff Center for Liver Diseases and Sylvester Comprehensive Cancer Center.

项目摘要/摘要（艾滋病毒和老化科学工作组） 迈阿密-CFAR HIV和老化科学工作组（HA-SWG）的长期目标是促进 通过多学科合作，创新和新兴的艾滋病毒和衰老研究领域。自从它 HA-SWG于2019年2月的成立于2019年2月，积极参与了针对该机制的研究 特定的挑战极大地影响了我们在南佛罗里达州及以后的艾滋病毒感染的老龄化人口。我们的 研究包括评估与HIV相关的合并症和免疫功能障碍，以及它们对脆弱和脆弱的影响 认知能力下降。多元车研究的总体主题旨在扩大 我们的SWG。在此应用程序中，我们提出了一个重点的重大修改的SWG 通过创建工作组的基于知识的活动。这些小组将研究特定的研究 利用创新方法的领域。免疫系统在衰老中的代谢调节的主题不足 研究以及HIV感染如何与年龄相关的免疫细胞代谢重编程及其相互作用 对免疫功能障碍和合并症早期发作的影响需要进一步研究。我们的 当前了解艾滋病毒（PWH）衰老的人的身体和认知脆弱的方法 翻译相关性。 HA-SWG将通过调查该领域的研究范围 肠脑轴和肝脑轴的作用在神经炎症的过程中，加速神经认知 衰老PWH的衰落和认知脆弱。在这里，我们提出了HA-SWG的两个具体目标。首先，要发展 并在免疫学领域促进创新的跨学科和协作转化研究 代谢调节，神经炎症，脆弱和心血管/肝脏合并症。第二，我们将发展 迈阿密大学（UM）科学界的教育和指导活动，同时增强 AIM 1中指定的研究目标。通过实现这些目标，HA-SWG努力为创建一个平台 UM跨学科研究通过弥合脆弱，认知能力下降和合并症的临床挑战。 这些努力还将支持基础科学研究研究代谢法规的基础机制 艾滋病毒和衰老的免疫力。 HA-SWG还致力于创建一个资源丰富的基础架构以支持 与艾滋病毒和衰老有关的跨学科建议，支持早期的调查人员和研究人员 艾滋病毒研究领域。为了实现我们的目标，HA-SWG是独特的位置，可以利用临床和基本 迈阿密 - 法律和基础设施可用于UM的研究资源和专业知识。 McKnight Brain Institute，神经认知科学与衰老中心，大脑健康综合中心， 糖尿病研究所临床和转化科学研究所，西夫肝病中心和 西尔维斯特综合癌症中心。