NeuronS_MATTR Network: Neuronal & Systems Mechanisms of Affective Touch & Therapeutic Tissue Manipulation Research Network

NeuronS_MATTR 网络：神经元

基本信息

批准号：
10451081
负责人：
Gregory John Gerling
金额：
$ 70.84万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-20 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10451081
关键词：
Address Adult Affect Affective American Animal Model Anxiety Area Attenuated Basic Science Biological Cells Chronic Clinical Collaborations Computer Models Development Discipline Engineering Epithelial Cells Ethnic Origin Fibroblasts Fostering Gender Geographic Locations Goals Health Human Immune Immune system Individual Industry Inflammation Integumentary system Interdisciplinary Study Intervention Intractable Pain Knowledge Mammals Manipulative Therapies Manuals Massage Measures Mechanical Stimulation Mechanics Mediating Methodology Mission Molecular Moods Mus Musculoskeletal System Nervous System Physiology Nervous system structure Neural Pathways Neurobiology Neurons Neurosciences Outcome Study Pain Pain management Pathway interactions Patient Outcomes Assessments Patients Pharmacological Treatment Pharmacology Physical therapy Physiological Physiology Pilot Projects Population Publications Relaxation Research Research Personnel Research Priority Resources Schools Scientist Signal Transduction Stress System Techniques Technology Therapeutic Effect Therapeutic Touch Time Tissue Engineering Tissues Touch sensation base body system career cell type cytokine diversity and equity healing human subject innovation innovative technologies intersectionality mechanical stimulus multidisciplinary neuromechanism neuromusculoskeletal opioid epidemic pain relief program dissemination programs psychosocial relating to nervous system repaired response social socioeconomics soft tissue spatiotemporal symposium tool

项目摘要

ABSTRACT / PROJECT SUMMARY The goal of this proposal is to establish a high-priority research network to identify mechanisms through which soft tissue manipulation (STM), such as massage, exerts biological effects on the nervous system, non-neural cells and tissues. Neuromusculoskeletal pain afflicts up to half of the adult U.S. population and is the most commonly cited health reason for receiving massage. Soft tissue manipulation has been shown to promote relaxation, reduce anxiety, attenuate pain, mitigate inflammation, and promote functional change. STM also offers non-addictive alternatives to pharmacological interventions for short-term pain relief. Although STM has been used widely since ancient times, the underlying mechanisms of STM’s beneficial effects are not well understood, and STM interventions are not optimized based on rigorous and compelling scientific evidence. Although mechanistic studies over the past decade have identified molecular, cellular and circuit mechanisms of discriminative touch sensation in mammals, how these neural pathways are engaged by STM is unknown. Moreover, the cells and circuits that mediate affective components of touch sensation have not been defined. To enable mechanistic research into therapeutic effects of STM, interdisciplinary research and new resources are needed. The field requires collaboration between manual therapists, neuroscientists, engineers, and cell biologists. Scientific conferences or other networking opportunities that bridge these disciplines do not currently exist. This application in response to RFA-AT-21-006 will create a cross-disciplinary research network of scientists and clinicians with the shared goal of developing technologies and collaborations to break barriers to progress. First, few quantifiable standards exist to rigorously measure either how therapists apply hands-on manipulations, or how these manipulations alter stress/strain fields in receiving tissues. Second, the field lacks technologies and computational models to quantify the spatiotemporal dynamics of STM techniques. Third, how non-neural signals and cell types, including cytokines, immune cells, fibroblasts, and epithelial cells, promote restorative repair versus fibrotic healing have not been defined. Our core investigative team consists of scientists and clinicians whose collective expertise spans physical therapy, neuroscience from molecules to circuits in the mouse and human nervous systems, engineering and tissue mechanics, and extraneural tissues including the immune, myofascial and integumentary systems. To advance mechanistic research on STM and mechanosensory signaling, the U24 network aims to 1) Organize a Conferences Program to promote inclusive networking and cross-disciplinary collaborations, draw diverse researchers and clinicians to the field, and foster mechanistic, multi-scale research on the neurobiology of mechanotherapy. 2) Implement a Pilot Project Program to generate new tools for quantifying force-based manipulations, testable hypotheses, and new mechanistic knowledge. 3) Rapidly and freely disseminate high-impact research to advance the field by sharing innovative concepts and technologies that define neural mechanisms of the beneficial effects of STM.

摘要 /项目摘要该提案的目的是建立一个高优先研究网络，以确定机制软组织操纵（STM），例如按摩，对神经系统，非神经系统执行生物学作用细胞和组织。神经肌肉骨骼疼痛遭受了最多一半的美国人群的痛苦，这是最大的通常引用的健康理由接受按摩。软组织操纵已被证明可以促进放松，减少动画，减轻疼痛，减轻注射并促进功能变化。也是STM 为短期缓解疼痛的药物干预提供了非添加性替代方案。虽然STM有自从古代以来，我们被广泛使用，STM有益效果的基本机制不好理解的，并且STM干预措施不会基于严格且引人注目的科学证据进行优化。尽管过去十年中的机械研究确定了分子，细胞和电路机制哺乳动物中的歧视性触摸感，这些神经途径如何由STM参与。此外，尚未定义媒体情感成分的细胞和圆圈。为了对STM，跨学科研究和新资源的治疗作用进行机械研究需要。该领域需要手动治疗师，神经科学家，工程师和细胞之间的合作生物学家。桥接这些学科目前没有的科学会议或其他网络机会存在。此应用程序响应RFA-AT-21-006将创建一个跨学科研究网络科学家和临床医生的共同目标是开发技术和合作，以打破障碍进步。首先，很少有可量化的标准可以严格衡量治疗师如何实践动手操纵或这些操作如何改变接收组织中的应力/应变场。其次，领域缺乏量化STM技术的时空动力学的技术和计算模型。第三，怎么非神经信号和细胞类型，包括细胞因子，免疫细胞，成纤维细胞和上皮细胞，促进尚未定义恢复性修复与纤维化愈合。我们的核心调查团队由科学家组成集体专业知识涵盖物理疗法的临床医生，分子的神经科学到电路小鼠和人类神经系统，工程和组织力学以及包括免疫，肌筋膜和整数系统。推进对STM和STM的机械研究机理感知信号传导，U24网络的目的是1）组织会议计划以促进包容性网络和跨学科合作，将潜水员的研究人员和临床医生吸引到该领域，并培养关于机械疗法神经生物学的机械，多尺度研究。 2）实施试点项目计划生成新工具，用于量化基于力的操作，可检验的假设和新机械知识。 3）快速自由传播高影响力的研究以通过共享创新性来推进该领域定义STM有益作用的神经机制的概念和技术。