NeuronS_MATTR Network: Neuronal & Systems Mechanisms of Affective Touch & Therapeutic Tissue Manipulation Research Network

NeuronS_MATTR 网络：神经元

基本信息

批准号：
10612050
负责人：
Gregory John Gerling
金额：
$ 63.94万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-20 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612050
关键词：
Adult Affect Affective American Animal Model Area Attenuated Basic Science Biological Cells Chronic Clinical Collaborations Computer Models Development Discipline Engineering Epithelial Cells Ethnic Origin Fibroblasts Fostering Gender Geographic Locations Goals Health Human Immune Immune system Individual Industry Inflammation Integumentary system Interdisciplinary Study Intervention Intractable Pain Knowledge Mammals Manipulative Therapies Manuals Massage Measures Mechanical Stimulation Mechanics Mediating Methodology Mission Molecular Moods Mus Musculoskeletal System Nervous System Nervous System Physiology Neural Pathways Neurobiology Neurons Neurosciences Pain Pain management Pathway interactions Patient Outcomes Assessments Patients Pharmacological Treatment Physical therapy Physiological Physiology Pilot Projects Population Publications Relaxation Research Research Personnel Research Priority Resources Schools Scientist Signal Transduction Stress System Techniques Technology Therapeutic Therapeutic Effect Therapeutic Touch Tissues Touch sensation anxiety reduction body system career cell type cytokine equity, diversity, and inclusion healing human subject innovation innovative technologies intersectionality mechanical stimulus multidisciplinary neural neuromechanism neuromusculoskeletal opioid epidemic pain relief pharmacologic program dissemination programs psychosocial repaired response social socioeconomics soft tissue spatiotemporal symposium tool

项目摘要

ABSTRACT / PROJECT SUMMARY The goal of this proposal is to establish a high-priority research network to identify mechanisms through which soft tissue manipulation (STM), such as massage, exerts biological effects on the nervous system, non-neural cells and tissues. Neuromusculoskeletal pain afflicts up to half of the adult U.S. population and is the most commonly cited health reason for receiving massage. Soft tissue manipulation has been shown to promote relaxation, reduce anxiety, attenuate pain, mitigate inflammation, and promote functional change. STM also offers non-addictive alternatives to pharmacological interventions for short-term pain relief. Although STM has been used widely since ancient times, the underlying mechanisms of STM’s beneficial effects are not well understood, and STM interventions are not optimized based on rigorous and compelling scientific evidence. Although mechanistic studies over the past decade have identified molecular, cellular and circuit mechanisms of discriminative touch sensation in mammals, how these neural pathways are engaged by STM is unknown. Moreover, the cells and circuits that mediate affective components of touch sensation have not been defined. To enable mechanistic research into therapeutic effects of STM, interdisciplinary research and new resources are needed. The field requires collaboration between manual therapists, neuroscientists, engineers, and cell biologists. Scientific conferences or other networking opportunities that bridge these disciplines do not currently exist. This application in response to RFA-AT-21-006 will create a cross-disciplinary research network of scientists and clinicians with the shared goal of developing technologies and collaborations to break barriers to progress. First, few quantifiable standards exist to rigorously measure either how therapists apply hands-on manipulations, or how these manipulations alter stress/strain fields in receiving tissues. Second, the field lacks technologies and computational models to quantify the spatiotemporal dynamics of STM techniques. Third, how non-neural signals and cell types, including cytokines, immune cells, fibroblasts, and epithelial cells, promote restorative repair versus fibrotic healing have not been defined. Our core investigative team consists of scientists and clinicians whose collective expertise spans physical therapy, neuroscience from molecules to circuits in the mouse and human nervous systems, engineering and tissue mechanics, and extraneural tissues including the immune, myofascial and integumentary systems. To advance mechanistic research on STM and mechanosensory signaling, the U24 network aims to 1) Organize a Conferences Program to promote inclusive networking and cross-disciplinary collaborations, draw diverse researchers and clinicians to the field, and foster mechanistic, multi-scale research on the neurobiology of mechanotherapy. 2) Implement a Pilot Project Program to generate new tools for quantifying force-based manipulations, testable hypotheses, and new mechanistic knowledge. 3) Rapidly and freely disseminate high-impact research to advance the field by sharing innovative concepts and technologies that define neural mechanisms of the beneficial effects of STM.

摘要/项目摘要该提案的目标是建立一个高度优先的研究网络，以确定机制，通过这些机制软组织操作（STM），例如按摩，对神经系统、非神经系统产生生物效应神经肌肉骨骼疼痛困扰着多达一半的美国成年人，并且是最严重的。人们普遍认为接受按摩的健康原因已被证明可以促进软组织按摩。放松、减少焦虑、减轻疼痛、减轻炎症并促进功能改变。尽管 STM 具有缓解短期疼痛的作用，但它提供了非成瘾性的药物干预替代方案。自古以来就被广泛使用，但其有益作用的潜在机制尚不清楚理解，并且 STM 干预措施并未基于严格且令人信服的科学证据进行优化。尽管过去十年的机制研究已经确定了分子、细胞和电路机制哺乳动物的辨别性触觉，STM 如何参与这些神经通路尚不清楚。此外，介导触觉情感成分的细胞和电路尚未被定义。实现 STM 治疗效果的机制研究、跨学科研究和新资源该领域需要手法治疗师、神经科学家、工程师和细胞之间的合作。目前还没有连接这些学科的科学会议或其他交流机会。该应用程序响应 RFA-AT-21-006 将创建一个跨学科研究网络。科学家和反叛者的共同目标是开发技术和合作以打破障碍首先，很少有可量化的标准来严格衡量治疗师如何实际应用。操作，或者这些操作如何改变接收组织中的应力/应变场。其次，该场缺乏。量化 STM 技术时空动态的技术和计算模型第三，如何实现。非神经信号和细胞类型，包括细胞因子、免疫细胞、成纤维细胞和上皮细胞，促进恢复性修复与纤维化愈合的关系尚未确定。我们的核心研究团队由科学家组成。以及战士，他们的集体专业知识涵盖物理治疗、从分子到电路的神经科学小鼠和人类神经系统、工程和组织力学以及神经外组织，包括免疫、肌筋膜和外皮系统推进 STM 和外皮系统的机制研究。机械传感信号，U24 网络的目标是 1) 组织会议计划以促进包容性网络和跨学科合作，吸引不同的研究人员和忠诚者进入该领域，并促进机械疗法神经生物学的机制、多尺度研究 2) 实施试点项目计划。生成新工具来量化基于力的操作、可检验的假设和新机制 3) 快速、自由地传播高影响力的研究成果，通过分享创新来推动该领域的发展。定义 STM 有益影响的神经机制的概念和技术。