Organ Design and Engineering Training Program (ODET Program)

器官设计与工程培训项目（ODET项目）

• 批准号: 10441516
• 负责人: JOSEPH VINCENT BONVENTRE
• 金额: $ 17.41万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441516
• 关键词: Engineering; Organ; Training Programs; design

The number of available organs for transplantation is severely limited by a shortage of donors. Regenerative medicine has emerged as a field that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. To develop functional tissue requires applying concepts in tissue engineering and molecular/developmental biology in innovative ways. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and the molecular/developmental biology disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training for postdoctoral fellows. Individuals accepted into the Program have experience focused in an engineering or biological discipline and are cross-trained in an area of expertise complementary to their primary research background. Working at the intersection of engineering and molecular/developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program meetings, where fellows and faculty cross-fertilize, and required coursework focused on biological science if fellows are engineers and engineering if their prior focus was in biology. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true “dual-mentor” model where fellows spend time in the laboratories of two mentors and benefit from active communication across laboratories, institutions and geographic boundaries. This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 10 years have high quality publications, have moved to academic faculty, international research labs and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges facilitated by close interactions with clinicians, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.

可用的移植器官数量受到捐助者短缺的严重限制。 再生医学已成为一个领域，它带来了设计和创造艺术的潜力 器官或器官的一部分，更接近现实。要开发功能组织，需要在 组织工程和分子/发育生物学以创新的方式。这需要一种新的类型 在工程和工程界面的概念和方法方面训练有素的科学家 分子/发育生物学学科。成功整合这些方法可能 动态地催化形成了一种新的跨学科方法。这会 对许多疾病的治疗产生深远影响。 ODET（器官设计和工程博士后培训）计划继续提供 科学严格的多学科研究培训，用于博士后研究员。个人接受 进入该计划的经验专注于工程或生物学纪律，并且经过交叉培训 在其主要研究背景的专业知识完善领域。在十字路口工作 工程和分子/发育/再生生物学，受训者学习一种新语言和 最终开发出有效桥梁学科的共同方言。新一代 学者们准备解决跨学科的器官设计和工程的复杂性 方法。该程序充满了出色的双门互动，定期安排 计划会议，研究员和教职员工交叉施肥，并需要进行课程工作 生物科学如果研究人员是工程师和工程，如果他们先前的重点是生物学。 自2007年成立以来，该计划已将培训发展的评估正式化为 并为研究演示和反馈提供了更多的机会。我们成功 从“一位博士后研究员 - 一个心理 - 一个 实验室“采用真正的“双门”模型的方法 导师和跨实验室，机构和地理的积极沟通受益 边界。该计划继续为培训提供建立独立所需的工具 调查人员以跨学科的科学方法来促进。得到支持的学员 从过去的十年中，这笔赠款有高质量的出版物，已搬到学术教师， 国际研究实验室和行业领导职务。我们期待继续训练 多学科研究的领导者，通过紧密互动准备的临床挑战暴露 在临床医生的同时，通过优化研究来评估和改善奖学金经验 下一代工程师评估者在再生医学中的心理机会。