Organ Design and Engineering Training Program (ODET Program)

器官设计与工程培训项目（ODET项目）

• 批准号: 9096101
• 负责人: JOSEPH VINCENT BONVENTRE
• 金额: $ 34.25万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9096101
• 关键词: Organ; Training Programs; engineering design

DESCRIPTION (provided by applicant): The number of available organs is severely limited by a shortage of donors. A new field of science, regenerative medicine, has emerged that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. T develop functional tissue requires applying concepts in developmental biology, quantitative science and tissue engineering approaches in a novel way. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and other disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training to postdoctoral fellows at Harvard and MIT. Individuals accepted into the Program are cross-trained in an area of expertise outside of their primary research field. This is a continuation of an ARRA-funded training program, reduced in size. Working at the intersection of engineering and developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program mentoring and a required course. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true ["dual-mentor" model where fellows spend time in the laboratories of two mentors and are able to facilitate active communication across laboratories, institutions and geographic boundaries.] This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 5 years have high quality publications, have moved to academic faculty, international research lab and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.

描述（由申请人提供）：可用器官的数量受到捐助者短缺的严重限制。出现了一个新的科学领域，即再生医学，它带来了设计和创造人造器官或器官的一部分，更接近现实的潜力。 t开发功能组织需要以新颖的方式应用概念在发育生物学，定量科学和组织工程方法中。这需要一种新型的科学家，他们在工程和其他学科的界面概念和方法中进行了良好的训练。成功整合这些方法可以极大地催化形成一种新的跨学科方法为器官建设。这将对许多疾病的治疗产生深远的影响。 ODET（器官设计和工程博士后培训）计划继续为哈佛大学和麻省理工学院的博士后研究员提供科学严格的多学科研究培训。接受该计划的个人在其主要研究领域以外的专业知识领域进行了交叉培训。这是ARRA资助的培训计划的延续，尺寸降低。在工程和发展/再生生物学的交汇处，学员学习了一种新语言，并最终开发了一种有效弥合学科的共同方言。新一代的学者准备通过跨学科方法来解决器官设计和工程的复杂性。该计划具有出色的双门互动，定期安排的计划指导和必需的课程。 自2007年成立以来，该计划已正式对学员的发展进行了正式评估，并为研究演示和反馈提供了更多的机会。我们成功地将标准的博士后培训模式从“一位博士后研究员 - 一名指导者 - 一项实验室”方法更改为真正的[“双重群体”模型，其中研究员在两位导师的实验室中度过了一段时间，并能够促进跨实验室，机构，机构和地理领域的积极沟通。在过去的5年中，从这笔赠款获得支持的学员拥有高质量的出版物，已搬到学术教师，国际研究实验室和行业领导职务。我们期待继续培训领导者进行多学科研究，并面临临床挑战，同时通过优化研究和指导下一代工程师评估者在再生医学领域的研究和指导机会，从而批判性地评估和改善奖学金经验。