Biospecimen Core

生物样本核心

• 批准号: 10441506
• 负责人: DAVID L RIMM
• 金额: $ 28.23万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-22 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441506
• 关键词: Biopsy; Blood; Cell Line; Clinical; Clinical Trials; Code; Collection; Communities; Cytometry; DNA Sequencing Facility; DNA sequencing; Data; Databases; Development; Excision; Formalin; Fox Chase Cancer Center; Freezing; Future; Genomics; Grant; Head and Neck Cancer; Head and Neck Squamous Cell Carcinoma; Head and neck structure; Human; Image; Immunohistochemistry; In Situ; Institution; Maintenance; Measurement; Messenger RNA; MicroRNAs; Neoplasm Metastasis; Nucleic acid sequencing; Paraffin Embedding; Pathologic; Pathology; Patients; Preparation; Proteins; Provider; Recurrence; Reproduction spores; Research; Resources; Serum; Services; Specimen; Tissue Banks; Tissues; Work; biobank; career; design; digital; fluorescence imaging; head and neck cancer patient; molecular pathology; nano-string; programs; prospective; sample collection; therapy resistant; tissue resource

SUMMARY The Biospecimen Core B is designed to support all aspects of this SPORE grant that need to use or analyze biospecimens. We have 4 specific aims that are designed to span the needs of the projects and include potential future work, including the DRPs and CDPs. Our aims include: Aim 1: To collect, store and distribute human biospecimens with complete clinical, pathological, and demographic annotation. Aim 2: To conduct or assist in the collection, maintenance and distribution of HNSCC cell lines. Aim 3: To conduct or assist in preparation for genomic analyses of biospecimens. And, Aim 4: To conduct or assist in the in situ molecular pathology analyses of biospecimens. In the body of the proposal we expand on our capacities and preliminary data for each aim. We also illustrate how the core will meet the needs of the relevant specific aims of each project. Overall, we look forward to being a key tissue provider and analysis facility to allow the SPORE project to seamlessly generate data from the Yale and Fox Chase Cancer Center tissue resources.

概括 Biospecimen Core B旨在支持需​​要使用或分析的孢子赠款的各个方面 生物测量。我们有4个旨​​在跨越项目需求并包括潜力的特定目标 未来的工作，包括DRP和CDP。我们的目标包括：目标1：收集，存储和分发人 具有完整的临床，病理和人口统计学注释的生物测量。目标2：进行或协助 HNSCC细胞系的收集，维护和分布。目标3：进行或协助准备 生物测量的基因组分析。并且，目标4：进行或协助原位分子病理学分析 生物测量。在提案的主体中，我们扩大了每个目标的能力和初步数据。 我们还说明了核心将如何满足每个项目相关特定目标的需求。总体而言，我们 期待成为关键组织提供商和分析设施，以使孢子项目无缝 从耶鲁大学和Fox Chase癌症中心组织资源中生成数据。