Core C: Biospecimen, Pathology, and Genomics Core

核心 C：生物样本、病理学和基因组学核心

基本信息

批准号：
10203853
负责人：
DAVID L RIMM
金额：
$ 38.5万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-26 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10203853
关键词：
Appointment Authorship Award Bioinformatics Biological Assay Biological Markers Biometry Biopsy Blood Cancer Biology Cerebrospinal Fluid Clinical Collection DNA Data Analyses Development Diagnostic Excision Funding Genomics Genotype Goals Health Health Services Research High-Throughput Nucleotide Sequencing Human Immune Immunologic Monitoring Joints K-Series Research Career Programs Leadership Malignant neoplasm of lung Measurement Medicine Messenger RNA Mission Modality Needle biopsy procedure Neoplasm Metastasis Operating Rooms Pathologic Pathology Patients Plasma Positioning Attribute Postdoctoral Fellow Preparation Primary Neoplasm Protein Tyrosine Kinase Proteins Recurrence Research Role Science Scientist Serum Services Signal Pathway Specimen Supervision Surgeon Time Tissue Banks Tissue Procurements Tissue Sample Tissues Tumor Tissue Work biobank career cytokine genome analysis meetings molecular marker molecular pathology novel personalized medicine professor success tumor DNA tumor-immune system interactions

项目摘要

PROJECT SUMMARY/ABSTRACT The Biospecimen, Pathology and Genomics (BPG) Core for the Yale Lung Cancer SPORE will serve as the facility for all human biospecimen acquisition, processing and analysis for all SPORE-sponsored research. We will continue to manage, bank and distribute lung cancers obtained from all interventionalists and surgeons as this occurs at the bedside or in the operating room with research tissues derived from extra passes of the biopsy needle after the diagnostic specimen has been collected. Furthermore, the Biospecimen, Pathology and Genomics Core will work closely with Yale Pathology Tissue Services, the research tissue procurement service supported within the Department of Pathology (also directed by David Rimm) to facilitate safe and rapid acquisition of all fresh lung cancer resection specimens. The Biospecimen, Pathology and Genomics Core presents the following specific aims to achieve the goals and mission of the Core in service to the Yale SPORE in Lung Cancer: Specific Aim 1. To collect, store and distribute human biospecimens with complete clinical, pathological, and demographic annotation for use in Projects 1-3, Developmental Projects and Career Enhancement Awards. Specific Aim 2. To conduct or assist in molecular pathology analyses of biospecimens including nine modalities for analysis of tyrosine kinase signaling pathways, immune microenvironment, immune profiling and immune monitoring.

项目摘要/摘要耶鲁肺癌孢子的生物测量，病理和基因组学（BPG）核心将作为所有人类生物循环收购，处理和分析的设施，用于所有孢子赞助的研究。我们将继续管理，银行和分发从所有干预主义者和外科医生获得的肺癌这发生在床边或手术室中，研究组织来自额外的通过诊断标本后的活检针已收集。此外，生物测量，病理学基因组学核心将与耶鲁病理组织服务紧密合作，研究组织采购病理学部（也由David Rimm指示）在支持安全和快速的服务部门支持的服务获取所有新鲜的肺癌切除标本。生物测量，病理和基因组学核心提出以下特定旨在实现核心为耶鲁孢子服务的目标和使命在肺癌中：具体目的1。通过完整的临床，病理和在项目1-3，发展项目和职业增强奖项中使用的人口注释。具体目的2。进行或协助对生物测量的分子病理分析，包括九种模态用于分析酪氨酸激酶信号通路，免疫微环境，免疫分析和免疫监视。