Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Coordinating Center- Supplement

HIV/AIDS 干预青少年医学试验网络 (ATN) 协调中心 - 补充资料

• 批准号: 10444497
• 负责人: Michael G Hudgens
• 金额: $ 499.14万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-03 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10444497
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine Trials Network; Adolescent Risk Behavior; Award; Awareness; Behavioral; Clinical; Coitus; Collaborations; Communication; Communities; Continuity of Patient Care; Data; Development; Ensure; Foundations; Funding; Goals; HIV; HIV Infections; Health Services Accessibility; High School Student; Human immunodeficiency virus test; Individual; Intervention; Intervention Studies; Leadership; Methods; National Institute of Child Health and Human Development; Operations Research; Parental Consent; Pharmaceutical Preparations; Preparation; Prevention trial; Protocols documentation; Publications; Reporting; Research; Research Support; Risk; Risk Behaviors; Solid; Students; Surveys; United States National Institutes of Health; Youth; adolescent health; condoms; design; experience; peer influence; programs; research study; self esteem; sexual encounter; social stigma; support network; young adult

ABSTRACT The goal of this U24 application is to extend our five-year award as Coordinating Center (CC) for the NICHD-sponsored Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) for one additional year. The objective of ATN is to increase awareness among at-risk youth of their HIV status and, for those with HIV, achieve linkage, engagement and retention in the care continuum. Many challenges are faced by adolescents during their transition to young adulthood, resulting from developmental changes, peer influences, identity, and self-esteem formation. Risky behaviors among adolescents, which include engaging in unprotected sexual encounters or sharing nonsterile injecting drug paraphernalia, increase their likelihood of acquiring HIV infection. In the 2013 US Youth Risk Behavior Surveillance Survey (YRBSS), 34% of US high school students reported sexual intercourse during the prior 3 months, of which only 59% indicated condom use during last sexual intercourse. The YRBSS also found that only 13% of students had ever been tested for HIV infection. Given the global burden of new HIV infections among young people, greater involvement of adolescents in biomedical and behavioral HIV research is essential. However, significant individual, operational, and community-level barriers have been recognized to engaging adolescents in clinical prevention trials, which include insufficient understanding of research, need for parental consent, lack of access, mistrust and stigma associated with research participation. For the past five years, the ATN has developed and implemented a comprehensive research portfolio to address these issues. As ATN Coordinating Center, we have supported the Network's research by providing scientific leadership and organizational support for ATN research studies and programs. During this extension year, we will continue to emphasize collaboration and provide experienced leadership to complete and close-out research studies across the network and disseminate findings through our various communication channels. Our research operations and administration teams will continue to provide a solid foundation to ATN by facilitating communication, conducting cross-protocol analyses to leverage Network research, supporting submission of study data to DASH, and supporting abstract and publication preparation and submission. This extension year will allow the extraordinary research conducted during this funding cycle of the ATN to be completed and disseminated for maximum impact on the health of adolescents at risk for or living with HIV/AIDS.

抽象的 该U24申请的目标是将我们的五年奖励作为协调中心（CC）延长 NICHD赞助的艾滋病毒/艾滋病干预措施（ATN）的青少年医学试验网络另外一份 年。 ATN的目的是提高高危青年对艾滋病毒地位的认识，以及 艾滋病毒，在护理连续体中实现联系，参与和保留。许多挑战面临 青少年在过渡到年轻成年期间，由于发展变化，同伴的影响， 身份和自尊的形成。青少年的冒险行为，包括参与 未受保护的性接触或共享非遗物注射毒品用具，增加了他们的可能性 获得HIV感染。在2013年美国青年风险行为监视调查（YRBSS）中，美国34％ 学校学生报告了前3个月的性交，其中只有59％表示避孕套 在上次性交中使用。 YRBS还发现，只有13％的学生接受过测试 艾滋病毒感染。考虑到年轻人中新的艾滋病毒感染的全球负担，更多地参与了 生物医学和行为HIV研究的青少年至关重要。但是，重要的人， 运营和社区水平的障碍已被认可吸引青少年参与临床预防 试验包括对研究的理解不足，需要父母同意，缺乏访问权限，不信任 和与研究参与有关的污名。在过去的五年中，ATN发展了， 实施了全面的研究组合来解决这些问题。作为ATN协调中心，我们 通过为ATN提供科学领导和组织支持来支持网络的研究 研究和计划。在这个延长年中，我们将继续强调协作和 提供经验丰富的领导才能在整个网络上完成和关闭的研究，并 通过我们的各种沟通渠道传播发现。我们的研究行动和管理 团队将继续通过促进沟通和进行沟通来为ATN提供坚实的基础 交叉协议分析以利用网络研究，支持将研究数据提交到破折号以及 支持抽象和出版的准备和提交。这个延期年将允许 在ATN的此资助周期中进行的非凡研究要完成并传播 最大程度地影响有艾滋病毒/艾滋病风险或生活的青少年的健康。

项目成果

Randomized Controlled Trial of a Remote Coaching mHealth Adherence Intervention in Youth Living with HIV.

• DOI: 10.1007/s10461-022-03717-2
• 发表时间: 2022-12
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Amico KR;Lindsey JC;Hudgens M;Dallas R;Horvath KJ;Dunlap A;Goolsby R;Johnson MM;Heckman B;Crawford J;Secord E;Purswani M;Reirden D;Rathore M;Robinson LG;Gaur AH;TERA Study Team
• 通讯作者: TERA Study Team

Correlates of High HIV Viral Load and Antiretroviral Therapy Adherence Among Viremic Youth in the United States Enrolled in an Adherence Improvement Intervention.

参与依从性改善干预措施的美国病毒血症青年中高 HIV 病毒载量与抗逆转录病毒治疗依从性的相关性。

• DOI: 10.1089/apc.2021.0005
• 发表时间: 2021
• 期刊: AIDS patient care and STDs
• 影响因子: 4.9
• 作者: Amico,KRivet;Crawford,Jessica;Ubong,Ini;Lindsey,JaneC;Gaur,AdityaH;Horvath,Keith;Goolsby,Rachel;MuellerJohnson,Megan;Dallas,Ronald;Heckman,Barbara;Filipowicz,Teresa;Polier,Melissa;Rupp,BettyM;Hudgens,Michael
• 通讯作者: Hudgens,Michael

Barriers and Facilitators to the Collection and Aggregation of Electronic Health Record HIV Data: An Analysis of Study Recruitment Venues Within the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN).

• DOI: 10.1177/0163278721998413
• 发表时间: 2021-06
• 期刊: Evaluation & the health professions
• 影响因子: 2.9
• 作者: Butame SA;De Leon JM;Lee SJ;Naar S;Genn L;Dark T;Kapogiannis BG
• 通讯作者: Kapogiannis BG

Rates of Sexually Transmitted Infection Diagnoses Among US Youth With Perinatally and Nonperinatally Acquired HIV.

• DOI: 10.1097/olq.0000000000001578
• 发表时间: 2022-03-01
• 期刊: Sexually transmitted diseases
• 影响因子: 3.1
• 作者: Neilan AM;DeMonte JB;Foote JHA;Karalius B;Patel K;Kapogiannis BG;Rudy BJ;Huszti H;Fernandez MI;Hudgens MG;Ciaranello AL
• 通讯作者: Ciaranello AL

Trajectories of Depressive Symptoms, Neurocognitive Function, and Viral Suppression With Antiretroviral Therapy Among Youth With HIV Over 36 months.

• DOI: 10.1097/qai.0000000000002653
• 发表时间: 2021-06-01
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Kohn JN;Loop MS;Kim-Chang JJ;Garvie PA;Sleasman JW;Fischer B;Rendina HJ;Woods SP;Nichols SL;Hong S
• 通讯作者: Hong S