Ovarian Cancer Survival in African-American Women

非裔美国女性卵巢癌的生存率

• 批准号: 10434896
• 负责人: Andrew B. Lawson
• 金额: $ 127.3万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10434896
• 关键词: Address; Affect; African American; Age; American; Analgesics; Archives; B-Lymphocytes; Biological Factors; Biological Markers; Cancer Etiology; Cancer Prognosis; Cancer Survivor; Case Study; Case-Control Studies; Censuses; Cessation of life; Characteristics; Clinical; Cohort Studies; Collection; Complex; Data; Data Collection; Data Sources; Databases; Diagnosis; Disease; Enrollment; Ensure; Environment; Epidemiologic Factors; Epidemiology; Epithelial ovarian cancer; European; Evaluation; Exposure to; Formalin; Funding; Geographic Locations; Goals; Health Services Accessibility; High Prevalence; Immunohistochemistry; Incidence; Individual; Inflammation; Inflammatory; Inflammatory Response; Infrastructure; Length; Life Style; Malignant neoplasm of ovary; Manuscripts; Measures; Medical Records; Methodology; Methods; Neighborhoods; Obesity; Outcome; Paraffin Embedding; Participant; Pathologic; Pathology; Pathway interactions; Patients; Pharmaceutical Preparations; Physical environment; Play; Polymerase Chain Reaction; Population; Positioning Attribute; Prevention strategy; Prognosis; Prognostic Factor; Proteins; Psychosocial Factor; Publishing; Quality of life; Questionnaires; Reproductive History; Research Design; Resources; Reverse Transcription; Risk; Risk Factors; Role; Sample Size; Site; Social Environment; Specimen; Therapeutic Intervention; Time; Tissues; Tumor Markers; Tumor Tissue; Tumor-Infiltrating Lymphocytes; Tumor-associated macrophages; United States; Woman; advanced disease; anticancer research; burden of illness; cancer diagnosis; cancer epidemiology; cancer survival; carcinogenesis; clinical effect; comorbidity; cytokine; epidemiology study; experience; follow-up; immune checkpoint; improved; individual patient; lifestyle factors; low socioeconomic status; mortality; mortality disparity; multidisciplinary; multilevel analysis; novel; recruit; residence; social factors; sociodemographic factors; survival disparity; virtual

ABSTRACT Although epithelial ovarian cancer (EOC) is the fifth-leading cause of cancer death in women in the U.S.—with worse survival in African-American (AA) women than European-American (EA) women—little is known about factors affecting survival among AAs. The causes for this disparity are likely multifactorial and need to be examined from multiple levels, including factors affecting the neighborhood social environment and individual- level factors. We posit that inflammatory exposures may explain some of the disparity in EOC survival among AA women due to important role of inflammation on carcinogenesis and prognosis and the higher levels of inflammatory biomarkers present among AA women. The African American Cancer Epidemiology Study (AACES) is a multi-site epidemiologic study of AA women in diverse geographic regions. Due to comprehensive data collection, pathology assessment and length of follow-up, AACES is uniquely positioned to evaluate factors influencing the survival of EOC in AA women. AACES has enrolled an unprecedented number of AA participants during a previous funding period, making AACES the largest study of ovarian cancer in AA women to date: 595 AA women with invasive EOC and 752 controls. Prior to AACES, no epidemiologic study of ovarian cancer had enrolled more than 150 AA cases and 150 AA controls. The overarching goal of this proposal is to assemble the first cohort study of AA EOC survivors by expanding recruitment to reach a sample size of ~944 cases and continuing follow-up of existing AACES cases. We propose a novel multi-level approach to evaluate the impact of neighborhood, lifestyle factors and biomarkers on survival. We propose the following aims that build on our current infrastructure and accomplishments: 1) investigate the effects of the neighborhood social and physical environment on EOC survival; 2) evaluate the association between individual characteristics and EOC survival; 3) characterize inflammatory tumor markers that may be key treatment targets; and 4) use multi-leveling modeling to integrate the impact of the Aim 1-3 variables. Our multi- disciplinary investigative team has extensive experience in all facets of ovarian cancer research, which ensures comprehensive, synergistic approaches to understanding factors that affect survival in AA women diagnosed with invasive EOC. The critical deficit of information on the epidemiologic and prognostic factors for ovarian cancer survival among AA women is addressed comprehensively in the proposed study. Our study will inform strategies to reduce mortality in AA women with EOC.

抽象的 尽管上皮卵巢癌（EOC）是美国女性癌症死亡的第五个领先原因，但 在非裔美国人（AA）妇女中的生存比欧洲妇女（EA）妇女更糟糕的是 影响AA生存的因素。这种差异的原因可能是多因素的，需要是 从多个层面进行检查，包括影响邻里社会环境和个人的因素 - 水平因素。我们肯定的是，炎症暴露可能解释了EOC生存的某些差异 AA妇女由于炎症的重要作用在致癌和预后以及较高水平 AA妇女中存在炎症生物标志物。非裔美国癌症流行病学研究 （AASS）是对潜水员地理区域中AA妇女的多站点流行病学研究。由于 全面的数据收集，病理评估和随访时间，AASS是独特的位置 评估因素影响AA妇女中EOC的生存。 AES招募了前所未有的 在以前的资金期间，AA参与者的数量使AAS成为最大的卵巢癌研究 在迄今为止的AA妇女中：595名AA妇女具有侵入性EOC和752个对照。在AASE之前，没有流行病学 对卵巢癌的研究已招募了150多例AA病例和150例AA对照。总体目标 该建议是通过扩大招聘以达到AA EOC存活的首次组装研究 样本大小约为944例，并继续对现有AASS案例进行随访。我们提出了一个新颖的多层次 评估社区，生活方式因素和生物标志物对生存的影响的方法。我们建议 以我们目前的基础设施和成就为基础的以下目标：1）研究 EOC生存的邻里社会环境； 2）评估个人之间的关联 特征和EOC生存； 3）表征可能是关键治疗的炎症性肿瘤标记 目标； 4）使用多级建模来整合AIM 1-3变量的影响。我们的多 纪律调查团队在卵巢癌研究的所有方面都有丰富的经验， 确保全面，协同的方法来理解影响AA妇女生存的因素 被诊断为侵入性EOC。有关流行病学和预后因素的信息的严重缺陷 在拟议的研究中，AA妇女的卵巢癌存活得到了详尽的解决。我们的研究愿意 告知策略以减少EOC的AA妇女死亡率。