Bayesian Modeling for Prenatal, Natal and Postnatal Predictors of Developmental Defects of Enamel in Primary Maxillary Central Incisor Teeth

上颌中切牙牙釉质发育缺陷的产前、产中和产后预测因子的贝叶斯模型

• 批准号: 10216219
• 负责人: Andrew B. Lawson
• 金额: $ 14.7万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216219
• 关键词: 1 year old; 5 year old; Address; Affect; Age-Months; Anterior; Apgar Score; Area; Bayesian Modeling; Birth; Calcium; Child; Cholecalciferol; Clinical; Clinical Trials; Cosmetics; Data; Data Analyses; Data Collection; Data Set; Defect; Dental; Dental Enamel; Dental Enamel Hypoplasia; Dental caries; Dental crowns; Development; Diet; Dietary Calcium; Disease; Double-Blind Method; Enamel Formation; Esthetics; Etiology; Expenditure; Fluorides; Follow-Up Studies; Future; General Anesthesia; Goals; Homeostasis; Hormones; Human; Hypocalcemia result; Image; Incisor; Infant; Infection; Intervention Studies; Joints; Knowledge; Learning; Low Birth Weight Infant; Maxilla; Methodology; Minerals; Modeling; Monitor; Mothers; National Institute of Dental and Craniofacial Research; Oral; Oral cavity; Oral health; Outcome; Parathyroid gland; Pharmaceutical Preparations; Phosphorus; Poverty; Predictive Factor; Pregnancy; Prenatal care; Prevalence; Prevention; Primary Dentition; Prospective Studies; Randomized; Research Project Grants; Risk; Structure; Supplementation; Testing; Tetracyclines; Time; Tooth Attrition; Tooth structure; Vitamin D; Vitamin D Deficiency; Weight; absorption; acquired factor; aged; calcification; cariogenic bacteria; cost; cost effective; data resource; deciduous tooth; design; early childhood; federal poverty level; genetic information; high risk; human model; indexing; infancy; maternal cigarette smoking; novel; outcome prediction; permanent tooth; postnatal; premature; prenatal; secondary analysis; social health determinants; validation studies

Project Abstract Developmental defects of enamel or DDE include enamel hypoplasia (EH), opacities (OP) and post-eruptive breakdown (PEB). DDE are defects in the structural integrity of the tooth that happen while the tooth is developing. EH is characterized by an area of less enamel and is a quantitative defect. OP are characterized as an area with a difference in translucency and are a qualitative defect. PEB is the loss of enamel after the tooth erupts into the mouth. DDE are a problem because EH can put the tooth at higher risk for dental caries, and both OP and PEB can be esthetic problems. The goal of our proposed study is to identify clinical and other factors, and the timing of these factors that result in DDE of primary maxillary central incisor teeth. Our hypothesis is that these predictors for DDE are related to calcium homeostasis. This study builds on our prior study which found pregnancy and birth factors related to calcium homeostasis that were predictive for EH. We now propose a more extensive study of the impact of maternal pregnancy factors, birth factors and early infancy factors on the development of DDE in the deciduous maxillary central incisor teeth. We study DDE in these two teeth because they begin calcification at 13-15 weeks of gestation, complete calcification by 4-6 weeks postnatal, and erupt at about 1 year of age. The enamel crowns of these two teeth serve as an irreversible record of pregnancy, birth and early infancy exposures. A best test of the cause-effect of maternal, birth and early infancy related factors is a prospective study of mothers with monthly monitoring of factors during pregnancy, at birth, then at early infancy and also following the children to examine their teeth which erupt into the oral cavity at about 1 year of age. We are uniquely poised to conduct secondary analyses of existing data resources so that we can identify the predictors and timing for these predictors during human tooth development and resultant DDE. We will compare and contrast the predictors for the different DDE outcomes to learn more about their development. We will develop Bayesian models that identify the predictors and their timing for DDE outcomes. The results of this study of existing data resources are designed to close the gap in knowledge about possibly modifiable predictors and also to provide an analytical approach to identify pregnancy, birth and early infancy predictors for DDE in the child. Results will also help with the design of future validation and intervention studies.

项目摘要 牙釉质或DDE的发育缺陷包括搪瓷发育不全（EH），不透明（OP）和爆发后 故障（PEB）。 DDE是牙齿发生的牙齿结构完整性的缺陷 发展。 EH的特征是搪瓷较少的区域，是定量缺陷。 OP是特征的 作为透明度差异并且是定性缺陷的区域。卵石是牙釉质的损失 牙齿爆发到嘴里。 DDE是一个问题，因为EH可以将牙齿的牙齿带来较高的龋齿， OP和PEB都可能是美学问题。我们拟议的研究的目的是确定临床和其他 因素，以及这些因素的时间，导致原发性上颌中央切牙牙齿的DDE。我们的 假设是这些DDE的预测因子与钙稳态有关。这项研究建立在我们先前的 研究发现，与钙稳态有关的妊娠和出生因素可预测EH。我们 现在，提出更广泛的研究对产妇妊娠因素，出生因素和早期的影响 婴儿期DDE在落叶上颌中切牙牙齿中的发展。我们研究DDE 这两个牙齿是因为它们在妊娠13-15周开始钙化，因此以4-6的形式完全钙化 产后几周，大约1岁。这两个牙齿的搪瓷冠充当 怀孕，出生和婴儿早期暴露的不可逆转记录。对母亲的原因的最佳测试， 出生和婴儿期有关的因素是对母亲每月监测因素的前瞻性研究 怀孕期间，出生时，然后在婴儿早期，也跟随孩子检查他们的牙齿 大约1岁时爆发进入口腔。我们有独特的准备进行次要分析 现有的数据资源，以便我们可以在人类期间确定这些预测指标的预测因素和时间安排 牙齿发育和由此产生的DDE。我们将比较和对比不同的DDE的预测指标 结果以了解有关其发展的更多信息。我们将开发贝叶斯模型来识别预测因子 以及他们对DDE结果的时机。现有数据资源的这项研究的结果旨在关闭 关于可能修改预测因子的知识差距，并提供一种分析方法 确定儿童DDE的怀孕，出生和婴儿早期预测因子。结果也将有助于设计 未来验证和干预研究。