Bayesian Modeling for Prenatal, Natal and Postnatal Predictors of Developmental Defects of Enamel in Primary Maxillary Central Incisor Teeth

上颌中切牙牙釉质发育缺陷的产前、产中和产后预测因子的贝叶斯模型

• 批准号: 10216219
• 负责人: Andrew B. Lawson
• 金额: $ 14.7万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216219
• 关键词: 1 year old; 5 year old; Address; Affect; Age-Months; Anterior; Apgar Score; Area; Bayesian Modeling; Birth; Calcium; Child; Cholecalciferol; Clinical; Clinical Trials; Cosmetics; Data; Data Analyses; Data Collection; Data Set; Defect; Dental; Dental Enamel; Dental Enamel Hypoplasia; Dental caries; Dental crowns; Development; Diet; Dietary Calcium; Disease; Double-Blind Method; Enamel Formation; Esthetics; Etiology; Expenditure; Fluorides; Follow-Up Studies; Future; General Anesthesia; Goals; Homeostasis; Hormones; Human; Hypocalcemia result; Image; Incisor; Infant; Infection; Intervention Studies; Joints; Knowledge; Learning; Low Birth Weight Infant; Maxilla; Methodology; Minerals; Modeling; Monitor; Mothers; National Institute of Dental and Craniofacial Research; Oral; Oral cavity; Oral health; Outcome; Parathyroid gland; Pharmaceutical Preparations; Phosphorus; Poverty; Predictive Factor; Pregnancy; Prenatal care; Prevalence; Prevention; Primary Dentition; Prospective Studies; Randomized; Research Project Grants; Risk; Structure; Supplementation; Testing; Tetracyclines; Time; Tooth Attrition; Tooth structure; Vitamin D; Vitamin D Deficiency; Weight; absorption; acquired factor; aged; calcification; cariogenic bacteria; cost; cost effective; data resource; deciduous tooth; design; early childhood; federal poverty level; genetic information; high risk; human model; indexing; infancy; maternal cigarette smoking; novel; outcome prediction; permanent tooth; postnatal; premature; prenatal; secondary analysis; social health determinants; validation studies

Project Abstract Developmental defects of enamel or DDE include enamel hypoplasia (EH), opacities (OP) and post-eruptive breakdown (PEB). DDE are defects in the structural integrity of the tooth that happen while the tooth is developing. EH is characterized by an area of less enamel and is a quantitative defect. OP are characterized as an area with a difference in translucency and are a qualitative defect. PEB is the loss of enamel after the tooth erupts into the mouth. DDE are a problem because EH can put the tooth at higher risk for dental caries, and both OP and PEB can be esthetic problems. The goal of our proposed study is to identify clinical and other factors, and the timing of these factors that result in DDE of primary maxillary central incisor teeth. Our hypothesis is that these predictors for DDE are related to calcium homeostasis. This study builds on our prior study which found pregnancy and birth factors related to calcium homeostasis that were predictive for EH. We now propose a more extensive study of the impact of maternal pregnancy factors, birth factors and early infancy factors on the development of DDE in the deciduous maxillary central incisor teeth. We study DDE in these two teeth because they begin calcification at 13-15 weeks of gestation, complete calcification by 4-6 weeks postnatal, and erupt at about 1 year of age. The enamel crowns of these two teeth serve as an irreversible record of pregnancy, birth and early infancy exposures. A best test of the cause-effect of maternal, birth and early infancy related factors is a prospective study of mothers with monthly monitoring of factors during pregnancy, at birth, then at early infancy and also following the children to examine their teeth which erupt into the oral cavity at about 1 year of age. We are uniquely poised to conduct secondary analyses of existing data resources so that we can identify the predictors and timing for these predictors during human tooth development and resultant DDE. We will compare and contrast the predictors for the different DDE outcomes to learn more about their development. We will develop Bayesian models that identify the predictors and their timing for DDE outcomes. The results of this study of existing data resources are designed to close the gap in knowledge about possibly modifiable predictors and also to provide an analytical approach to identify pregnancy, birth and early infancy predictors for DDE in the child. Results will also help with the design of future validation and intervention studies.

项目摘要 牙釉质或 DDE 的发育缺陷包括牙釉质发育不全 (EH)、牙釉质混浊 (OP) 和萌芽后 击穿（PEB）。 DDE 是牙齿在修复过程中发生的结构完整性缺陷。 发展。 EH 的特点是牙釉质区域较少，是一种定量缺陷。 OP 的特点 作为半透明度差异的区域，属于质量缺陷。 PEB是牙釉质的损失 牙齿长出口腔。 DDE 是一个问题，因为 EH 会使牙齿面临​​更高的龋齿风险， OP 和 PEB 都可能造成美观问题。我们提出的研究的目标是确定临床和其他 因素，以及这些因素导致上颌乳中切牙 DDE 的时间。我们的 假设这些 DDE 预测因素与钙稳态有关。这项研究建立在我们之前的基础上 研究发现与钙稳态相关的妊娠和出生因素可预测 EH。我们 现在建议对孕产妇怀孕因素、出生因素和早期妊娠的影响进行更广泛的研究 婴儿期因素对上颌乳中切牙 DDE 发育的影响。我们研究DDE 这两颗牙齿在怀孕13-15周时开始钙化，4-6周完全钙化 产后几周，约一岁时爆发。这两颗牙齿的牙釉质冠充当 怀孕、分娩和婴儿早期暴露的不可逆转的记录。母体因果关系的最佳检验， 出生和婴儿早期相关因素是一项对母亲进行的前瞻性研究，每月监测这些因素 在怀孕期间、出生时、婴儿早期以及跟随孩子检查他们的牙齿 1岁左右长出口腔。我们有独特的能力进行二次分析 现有的数据资源，以便我们可以在人类活动期间识别预测因素和这些预测因素的时间 牙齿发育和由此产生的 DDE。我们将比较和对比不同 DDE 的预测变量 成果，以更多地了解他们的发展。我们将开发识别预测变量的贝叶斯模型 以及他们获得 DDE 结果的时间。这项对现有数据资源的研究结果旨在关闭 关于可能可修改的预测变量的知识差距，并提供一种分析方法 确定儿童 DDE 的妊娠、出生和婴儿早期预测因素。结果也将有助于设计 未来的验证和干预研究。