Bridging Genomics and Medicine by Ontology Fingerprints
通过本体指纹连接基因组学和医学
基本信息
- 批准号:8042355
- 负责人:
- 金额:$ 26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:Basic ScienceBiologyBody Weight decreasedClinicalClinical MedicineClinical ResearchComplexComputerized Medical RecordDataDiabetes MellitusDiagnosisDiseaseExplosionFaceFatty LiverFingerprintGenesGenetic TranscriptionGenomeGenomicsGoalsHumanInterventionInvestigationLinkLiteratureMedicalMedicineMethodsModelingMolecularObesityOntologyOutcomePaperPathologyPathway interactionsPatientsPlayPubMedPublic HealthResearchRoleSouth CarolinaSymptomsTestingTimeTranslatingTranslationsabstractingbariatric surgerybiomedical ontologyclinical careclinical practicegene functionimprovedinformation gatheringinsightnovelnovel strategiesweb services
项目摘要
DESCRIPTION (provided by applicant):
Translating genomic research into clinical practice faces tremendous challenges due to significant gaps between the two domains. To fill this gap, we have developed the concept of an ontology fingerprint - a set of ontology terms overrepresented in the PubMed abstracts linked to a gene or a disease along with the terms' corresponding enrichment p-value, to characterize genes and diseases. We further have quantified the relationship between a gene and a disease by comparing the ontology fingerprints of each - the more similar the ontology fingerprint between a gene and a disease, the more likely the gene plays a role in the disease.
Hypothesis: Our overarching hypothesis is that new insights into the molecular mechanisms of complex diseases and translation of such insights into clinical practice can be achieved by developing ontology fingerprints from biomedical ontology and PubMed to bridge the gap between clinical medicine and genomics. This global hypothesis will be first evaluated by analyzing the reversal of diabetes, hepatic steatosis and obesity by gastric bypass surgery (GBS).
Specific Aims: (1) test the hypothesis that a novel gene network can be constructed by comparing the ontology fingerprints of human genes derived from the biomedical literature and available biomedical ontologies. (2) test the hypothesis that the novel gene network and ontology fingerprints can be used to decipher the molecular mechanisms of the reversal of diabetes and hepatic steatosis following GBS. (3) deploy ontology fingerprint to bridge the gap between genome information and clinical medicine.
Significance: These studies will link genomic information to clinical concepts and translate biomedical literature and genomic information into clinical practice by employing ontology fingerprints to decipher the interplay and reversal of obesity, diabetes and hepatic steatosis after GBS. Bridging the gap between genomics and medicine by ontology fingerprints will enhance the delivery of clinical care to patients.
描述(由申请人提供):
将基因组研究转化为临床实践,由于两个领域之间的巨大差距,面临巨大的挑战。为了填补这一空白,我们开发了本体学指纹的概念 - 与基因或疾病相关的PubMed摘要中的一组本体术语,以及“相应的富集p值”,以表征基因和疾病。我们通过比较每种本体的指纹(基因与疾病之间的本体学指纹越相似),进一步量化了基因与疾病之间的关系,基因在疾病中的作用越大。
假设:我们的总体假设是,可以通过开发从生物医学本体论和PubMed开发本体学指纹来实现对复杂疾病的分子机制以及将这种见解转化为临床实践的新见解。该全球假设将首先通过分析胃搭桥手术(GBS)的糖尿病,肝脂肪变性和肥胖的逆转来评估。
具体目的:(1)检验以下假设:可以通过比较源自生物医学文献和可用生物医学本体学的人类基因的本体指纹来构建新型基因网络。 (2)检验了新型基因网络和本体学指纹可用于破译GBS后糖尿病和肝脂肪变性的分子机制的假设。 (3)部署本体学指纹以弥合基因组信息与临床医学之间的差距。
意义:这些研究将通过使用本体论指纹指纹将基因组信息与临床概念联系起来,并将生物医学文献和基因组信息转化为临床实践,以破译GBS后肥胖,糖尿病和肝脂肪变性的相互作用和逆转。通过本体学指纹弥合基因组学和药物之间的差距将增强向患者的临床护理提供。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Andrew B. Lawson其他文献
Imputational modeling of spatial context and social environmental predictors of walking in an underserved community: The PATH trial
- DOI:
10.1016/j.sste.2012.10.001 - 发表时间:
2013-03-01 - 期刊:
- 影响因子:
- 作者:
Dawn K. Wilson;Caitlyn Ellerbe;Andrew B. Lawson;Kassandra A. Alia;Duncan C. Meyers;Sandra M. Coulon;Hannah G. Lawman - 通讯作者:
Hannah G. Lawman
Computation
- DOI:
10.1201/9781003043997-4 - 发表时间:
- 期刊:
- 影响因子:0
- 作者:
Andrew B. Lawson - 通讯作者:
Andrew B. Lawson
Approaches to the space-time modelling of infectious disease behaviour.
传染病行为时空建模方法。
- DOI:
- 发表时间:
2000 - 期刊:
- 影响因子:0
- 作者:
Andrew B. Lawson;Petra Leimich - 通讯作者:
Petra Leimich
Andrew B. Lawson的其他文献
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{{ truncateString('Andrew B. Lawson', 18)}}的其他基金
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- 批准号:
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- 资助金额:
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Bayesian Modeling for Prenatal, Natal and Postnatal Predictors of Developmental Defects of Enamel in Primary Maxillary Central Incisor Teeth
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- 批准号:
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- 资助金额:
$ 26万 - 项目类别:
Ovarian Cancer Survival in African-American Women
非裔美国女性卵巢癌的生存率
- 批准号:
10207548 - 财政年份:2020
- 资助金额:
$ 26万 - 项目类别:
Ovarian Cancer Survival in African-American Women
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- 批准号:
10434896 - 财政年份:2020
- 资助金额:
$ 26万 - 项目类别:
Advances in Geospatial Survival Modeling for Small Area Cancer Data
小区域癌症数据地理空间生存建模的进展
- 批准号:
8705126 - 财政年份:2014
- 资助金额:
$ 26万 - 项目类别:
Advances in Geospatial Survival Modeling for Small Area Cancer Data
小区域癌症数据地理空间生存建模的进展
- 批准号:
8828611 - 财政年份:2014
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Surveillance of Spatial Case Event Data in Cancer Studies
癌症研究中空间案例事件数据的监测
- 批准号:
8705128 - 财政年份:2014
- 资助金额:
$ 26万 - 项目类别:
Bridging Genomics and Medicine by Ontology Fingerprints
通过本体指纹连接基因组学和医学
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8530277 - 财政年份:2012
- 资助金额:
$ 26万 - 项目类别:
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$ 26万 - 项目类别:
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