Menstrual health during the Covid-19 pandemic: A longitudinal study among young people with and without endometriosis

Covid-19 大流行期间的月经健康：对患有和不患有子宫内膜异位症的年轻人进行的纵向研究

• 批准号: 10434356
• 负责人: Asgerally T. Fazleabas
• 金额: $ 27.46万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10434356
• 关键词: Accounting; Administrative Supplement; Adolescence; Adolescent and Young Adult; Adult; Affect; Anxiety; COVID-19; COVID-19 pandemic; COVID-19 vaccination; Characteristics; Data; Data Collection; Disease; Distress; Economics; Enrollment; Gynecologic; Hand; Health; Home; Individual; Infection; Irregular Menstruation; Longitudinal Studies; Medical; Menorrhagia; Menstrual cycle; Menstruation; Mental Depression; Mental Health; Modification; Parents; Participant; Pelvic Pain; Pelvis; Persons; Pharmaceutical Preparations; Population; Prospective Studies; Questionnaires; Reporting; Research; Resources; SARS-CoV-2 infection; Sample Size; Sampling; Series; Severities; Social isolation; Stress; Symptoms; Testing; Time; Vaccinated; Vaccination; Woman; Women' s Health; chronic pelvic pain; cohort; coping; coping mechanism; cost; endometriosis; frailty; health care availability; human data; inflammatory marker; interest; pandemic disease; prospective; psychosocial; sample collection; social

PROJECT SUMMARY/ABSTRACT Despite prevalent anecdotal reports, the impact of SARS-CoV-2 infection or vaccination on menorrhagia and menstrual regularity remains largely undocumented and unstudied. COVID-19 disease has impacted millions, while stay-at-home orders and heightened stress have impacted billions. Menorrhagia, menstrual irregularity, and chronic pelvic pain (with or without endometriosis) are known to increase in severity when challenged with stress, unraveling of personal coping mechanisms, or diminished access to healthcare – all of which occurred during the COVID-19 pandemic. To successfully assess changes in menstrual and gynecologic characteristics attributable to SARS-CoV-2 infection or vaccination, it is critical to compare post-infection or post-vaccination menstruation and pelvic symptoms to that person’s pre-exposure menstruation and also to compare menstruation among those who have been infected or vaccinated to those who have not, accounting for pandemic impacts that may vary by individual social or economic frailty and mental health. Answering these critical questions with scientific rigor in existing research cohort populations is responsive to Notice of Special Interest (NOSI) to Encourage Administrative Supplement Applications to Investigate COVID-19 Vaccination and Menstruation (NOT-HD-21-035). We will utilize an ongoing prospective study, the Women’s Health Study: from Adolescence to Adulthood (A2A, N=1569) - the core cohort included in the Parent R01 (HD094842). Cohort participants have completed annual questionnaires since enrollment began in 2012, which includes assessment of menstrual characteristics. Leveraging this cohort to compare and contrast prospectively collected pre-, peri-, and post-pandemic characteristics and inflammatory markers, we will test these hypotheses: a) SARS-CoV-2 infection is associated with incident or worsened menorrhagia, menstrual irregularity or pelvic pain compared to pre-pandemic and pre-infection menstrual characteristics within individual women, and compared to women who have not been infected; b) SARS-CoV-2 vaccination is associated with incident or worsened menorrhagia, menstrual irregularity or pelvic pain, as has been reported anecdotally, compared to pre-vaccination menstrual characteristics within individuals, and compared to unvaccinated women; and c) Increase in COVID-19 pandemic-related distress (e.g. depression, anxiety, social isolation, economic peril) and diminished healthy coping will be associated with incident or increased severity of menorrhagia, menstrual cycle irregularity, or chronic pelvic pain – independent of SARS-CoV-2 infection or vaccination. While many are scrambling to assemble research teams and establish de novo human data and sample collection, which will yield uncertain deliverables, small samples sizes, and often reliance on fully de-identified samples from which confounding and modification cannot be validly assessed, the proposed study capitalizes on well-established resources providing cost and time efficiency as well as scientifically robust opportunity.

项目摘要/摘要 尽管轶事报道很普遍，但SARS-COV-2感染或疫苗接种对月经和疫苗的影响 月经的规律性在很大程度上没有证件和未研究。 Covid-19疾病影响了数百万， 尽管在家订单和压力加剧却影响了数十亿。月经，月经不规则， 已知在受到挑战时，已知慢性骨盆疼痛（有或没有子宫内膜异位症）的严重程度会增加 压力，个人应对机制的压力，或获得医疗保健的机会减少 - 所有这些都发生了 在19号大流行期间。成功评估月经和妇科特征的变化 归因于SARS-COV-2感染或疫苗，比较后感染或疫苗接种至关重要 月经和骨盆符号与该人的暴露前月经，也比较 那些未感染或接种未接种的人的月经 大流行的影响可能会因个人或经济脆弱和心理健康而异。回答这些 现有研究队列人群中科学严谨的关键问题对特殊通知有回应 利息（NOSI）鼓励行政补充申请调查COVID-19-19和 月经（非HD-21-035）。我们将利用一项正在进行的前瞻性研究，即妇女健康研究： 青少年到成年（A2A，n = 1569） - 父r01（HD094842）中包含的核心队列。队列 自2012年入学开始以来，参与者已经完成了年度问卷，其中包括评估 月经特征。利用此队列比较和对比预期收集了前，骨 以及大流行特征和炎症标记，我们将检验以下假设：a）SARS-COV-2 感染与一般性或月经恶化，月经不规则或骨盆疼痛有关 单个女性的流行前和感染前的月经特征，并与 尚未感染； b）SARS-COV-2疫苗接种与一般性或月经恶化有关， 与疫苗接种前的月经相比，月经不规则或骨盆疼痛曾报道 个体内部的特征，并与未接种疫苗的妇女进行比较； c）COVID-19的增加 与大流行有关的困扰（例如抑郁，焦虑，社会隔离，经济危险）并减少了健康 应对将与月经期，月经周期不规则或增加的严重程度有关或 慢性骨盆疼痛 - 独立于SARS-COV-2感染或疫苗接种。虽然许多人在争先恐后 组装研究团队并建立从头开始的数据和样本收集，这将产生不确定的 可交付成果，小样品尺寸以及通常依赖完全识别的样品，从中混淆和 修改无法进行有效评估，拟议的研究资源是根据提供的良好资源提供的 成本和时间效率以及科学强大的机会。