Core B - Animal Core

核心 B - 动物核心

基本信息

批准号：
10427250
负责人：
Evan T Keller
金额：
$ 34.56万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-06-05 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10427250
关键词：
American Anesthesia procedures Animal Experiments Animal Model Animals Biology Bone Density Bone neoplasms Clinical Collaborations Complication Data Analyses Dual-Energy X-Ray Absorptiometry Ensure Genetically Engineered Mouse Goals Grant Human Resources Image Implant Individual Injections Institutes Internal Medicine Laboratory Animal Medicine Laboratory Animals Maintenance Malignant neoplasm of prostate Metastatic Neoplasm to the Bone Methods Modeling Nature Oncologist Performance Procedures Research Research Personnel Resource Sharing Role Scanning Services Standardization Translating Veterinarians animal data animal imaging base bioluminescence imaging bone cancer imaging college experience experimental study implantation in vivo in vivo imaging neoplastic cell programs soft tissue spine bone structure vertebra body

项目摘要

Core B: Animal Core Summary One of the synergistic aspects of the current Program Project is that all of the individual projects will evaluate some aspect of their research questions in several common models, e.g., intracardiac and intratibial injection of tumor cells. Having common animal models allows us to rapidly translate findings from one project to another project. Due to the unique nature of bone compared to soft tissues, many models of bone metastasis are challenging and require special expertise. The Animal Core has provided extensive service to the Program in the previous grant cycle. The goal of the Animal Core, which has rated Superior, in previous reviews, is to continue to provide investigators of each project with assistance in the conduct of research involving animals including establishment of unique animal models (e.g., vertebral body implants known as vossicles), intracardiac and intratibial injection, in vivo and ex vivo tumor imaging and miscellaneous animal procedures. The core has been very successful achieving its goals and has always rated Superior in reviews. To continue to accomplish support of the Program the Animal Core has the following Aims: Aim 1. Creating and assessing animal models to be used for the projects. In addition to routine animal modeling, we will facilitate use of animal models unique to bone metastasis research or that are challenging. For example, implantation of vertebrae to create vossicles, intratibial injections, intracardiac injections and orthotopic implants will be performed by the Animal Core. Aim 2. Assisting with animal experiments. Core personnel will coordinate and assist or instruct in the performance of standardized procedures such as in vivo imaging, intracardiac injections, compound injections, anesthesia, etc. Aim 3. Imaging animals. The core will assist with imaging including faxitron radiographs, bioluminescent imaging, bone density (DEXA) scanning and CT. Aim 4. Providing expertise in use of animal models and interpretation of data from these animals. Dr. Evan Keller, a Board-certified veterinary oncologist and Dr. Jill Keller, a Board- certified laboratory animal veterinarian, will provide expertise in interpretation of animal models as needed. Aim 5. Ensuring all animal experiments have appropriate animal compliance. In collaboration with Administrative core, we will ensure that all experiments are performed under appropriate institute approval

核心 B：动物核心总结当前计划项目的协同方面之一是所有单个项目将在几个常见模型中评估他们研究问题的某些方面，例如，心脏内和胫骨内注射肿瘤细胞使我们能够由于骨骼的独特性质，可以将一个项目的发现快速转化为另一个项目。与软组织相比，许多骨转移模型都具有挑战性，需要特殊的动物核心在过去为该计划提供了广泛的服务。在之前的评论中，动物核心的资助周期的目标是：继续为每个项目的研究人员提供研究协助动物涉及建立独特的动物模型（例如椎体植入物（称为囊泡）、心内和胫骨内注射、体内和离体肿瘤成像和其他动物程序的核心已经非常成功地实现了它。目标并始终在评论中评为优秀继续实现对的支持。动物核心计划有以下目标：目标 1. 创建和评估用于项目的动物模型。常规动物建模，我们将促进使用骨转移特有的动物模型研究或具有挑战性的研究，例如植入椎骨以产生囊泡，胫骨内注射、心内注射和原位植入将由动物核心。目标2.协助动物实验。核心人员将协调和协助或。指导标准化程序的执行，例如体内成像、心内成像注射剂、复方注射剂、麻醉等目标 3. 对动物进行成像，核心将协助成像，包括 Faxitron 射线照片、生物发光成像、骨密度 (DEXA) 扫描和 CT。目标 4. 提供动物模型使用和数据解释方面的专业知识埃文·凯勒 (Evan Keller) 博士是经过委员会认证的兽医肿瘤学家，吉尔·凯勒 (Jill Keller) 博士是委员会认证的动物。经过认证的实验动物兽医，将提供动物模型解释方面的专业知识根据需要。目标 5. 确保所有动物实验都具有适当的动物依从性。与行政核心合作，我们将确保所有实验均在适当的机构批准