Aging Rodent Core

老化啮齿动物核心

• 批准号: 8122845
• 负责人: Evan T Keller
• 金额: $ 9.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122845
• 关键词: Age; Aging; Aging-Related Process; Animal Model; Biology of Aging; Disease; Elderly; Faculty; Gerontology; Goals; Histopathology; Investigation; Knock-out; Molecular Biology; Mus; Preparation; Production; Protocols documentation; Rattus; Research Personnel; Rodent; Services; Shock; Slide; Transgenic Animals; Transgenic Organisms; Work; aged; cost; design; member; mutant

Aging Rodent Core: Evan Keller, Director The central purpose of the Aging Rodent Core (ARC) is to promote the use of mutant and transgenic rodents for investigations of the cellular and molecular biology of aging and the relationship of the aging process to late life disease. The ARC will accomplish its goals through three inter-related initiatives. (1) ARC will pay for per diem costs for investigators who wish to produce aged mice, typically of mutant or transgenic or knockout stocks, that are not otherwise available at older ages. (2) ARC will work with the UM Transgenic Animal Model Facility (TAMF), directed by Sally Camper and Thom Saunders, to assist Shock Center investigators to pay for TAMF services needed to prepare new transgenic or KO mice (and rats) for work in biogerontology. (3) ARC will promote the incorporation of histopathology in such projects by subsidizing the costs of slide preparation for selected projects (roughly 2/year) involving the production of aged mice by NSC researchers. In all these efforts, the ARC Director will provide advice on protocol design and selection of appropriate animal models to UM faculty members who wish to use aged rodents for their studies.

老化啮齿动物核心：Evan Keller，总监 衰老啮齿动物核心（ARC）的中心目的是促进使用突变和转基因啮齿动物来研究衰老的细胞和分子生物学以及衰老过程与晚年疾病的关系。 ARC 将通过三项相互关联的举措来实现其目标。 (1) ARC 将为希望生产老年小鼠的研究人员支付每日费用，这些小鼠通常是突变体、转基因或基因敲除小鼠，这些小鼠在老年小鼠中无法获得。 (2) ARC 将与由 Sally Camper 和 Thom Saunders 指导的 UM 转基因动物模型设施 (TAMF) 合作，协助休克中心研究人员 支付为生物老年学工作准备新的转基因或 KO 小鼠（和大鼠）所需的 TAMF 服务。 (3) ARC 将通过补贴涉及 NSC 研究人员生产老年小鼠的选定项目（大约每年 2 次）的载玻片制备费用，促进将组织病理学纳入此类项目。 在所有这些努力中，ARC 主任将向希望使用老年啮齿动物进行研究的 UM 教员提供有关方案设计和选择适当动物模型的建议。