Administrative Core

行政核心

• 批准号: 10416035
• 负责人: Robert O Wright
• 金额: $ 50.13万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10416035
• 关键词: Address; Age; Analytical Chemistry; Automation; Bioinformatics; Biological Assay; Biological Markers; Biology; Blinded; Budgets; Chemical Exposure; Chemicals; Child Health; Client; Clinical Laboratory Information Systems; Clinical Medicine; Communication; Computer software; Consultations; Core Facility; Counseling; Data; Data Reporting; Databases; Development; Disease; Dose; Educational workshop; Ensure; Environmental Exposure; Environmental Health; Epidemiologist; Epidemiology; Exposure to; Faculty; Feedback; Fostering; Freezing; Funding; Genus Tagetes; Goals; Grant; Health; Hemolysis; Human; Human Development; Human Resources; Infrastructure; Label; Laboratories; Lead; Leadership; Life Cycle Stages; Life course epidemiology; Link; Liquid substance; Management Information Systems; Measures; Medical; Medicine; Metadata; Metals; Methodology; Methods; Mission; Modeling; Modernization; Nutritional; Occupations; Online Systems; Organization administrative structures; Parents; Participant; Peer Review; Phenotype; Physicians; Plant Roots; Plasma; Play; Population; Predisposition; Preparation; Procedures; Process; Protocols documentation; Publications; Quality Control; Recommendation; Reporting; Research; Research Design; Research Personnel; Resources; Robotics; Route; Running; Sampling; Scientist; Services; Ships; Specimen; Statistical Data Interpretation; Stress; Structure; Study Subject; Sum; System; Testing; Time; Tooth structure; Toxicology; United States National Institutes of Health; Urine; Work; arm; base; biomarker development; data centers; data management; design; experience; flexibility; gene environment interaction; indexing; innovation; instrument; instrumentation; interest; meetings; multidisciplinary; novel; nutrition; obesogen; operation; outreach; prevent; programs; quality assurance; social; software systems; specific biomarkers; success; targeted biomarker; trait; user-friendly

Project Summary: Administrative Core The Administrative Core is the overarching organizational unit and serves as the main communication arm of the Mount Sinai Targeted HHEAR Lab Hub, working directly with the HHEAR Coordinating Center (CC), Data Center (DC) and NIH program staff. We collaborate and communicate with the other Lab Hubs on QA/QC programs including proficiency testing, common QC pools, technical replicates, blinded duplicates, and methods to minimize batch effects and inter-lab variability, issues for which our team played key roles in the first grant cycle of CHEAR. We coordinate internally to maximize efficiency and can nimbly alter our priorities as directed by the CC (i.e. if specific biomarkers are needed based on demand). We organize weekly Steering Committee (SC) meetings of the Hub to coordinate intra-Hub work flow including receipt of sample shipments, re-labeling, tracking, and entry in to our laboratory information management system (LIMS). We organize PI/Client consultation meetings in which we review the parent study for design, sample specimen availability/quality, study subject exposure scenarios, health phenotypes, and requested types of chemicals exposures to be measured. We then make recommendations that best fit the PI/Client's goals, while addressing any scientific or technical issues that may limit feasibility prior to conducting assay analysis. We also track the progress of on-going jobs and generate regular reports to the Coordinating Center, Data Center and NIH program. We coordinate data reporting with the HHEAR Data Center (DC), ensuring that our databases are properly formatted and contain the appropriate metadata. We also collaborate with the DC and Client/PI in the interpretation of results, (i.e. how hemolysis may impact levels of metals in plasma, which chemicals measured in urine are candidate obesogens etc.) and the statistical analysis of exposure/phenotype relationships. We organize and implement an annual Lab Hub workshop that engages existing and potential clients in Exposure assay methodologies. We were the only Lab Hub to organize such a meeting under CHEAR which was themed on exposomics and drew 200 scientific participants. We use a web based LIMS interface for tracking job progress through the Lab Hub system and to assess QA/QC in real time during analysis. In sum, we 1) coordinate communication internally within the Lab Hub and externally with the Coordinating Center, Data Center, PI/Clients and NIH program; 2) develop the procedures, protocols and system checks to ensure samples flow to the correct Resource/Core and that QA/QC protocols are followed rigorously; 3) maintain a LIMS that is user friendly, facilitates sample tracking, prevents mismatches between samples and results, and integrates with the needs of the Data Center; 4) provide scientific consultation services to PI/Clients that maximizes the information and quality of their study results; 5) ensure that feedback communication occurs between Clients and Resources/Cores and that this information is relayed transparently to the CC and NIH and 6) ensure transparent fiscal management of the Tageted Lab Hub program.

项目摘要：行政核心 行政核心是总体组织部门，是 西奈山针对HHEAR LAB HUB，直接与Hear协调中心（CC）合作，数据 中心（DC）和NIH计划人员。我们在QA/QC上与其他实验室进行协作并进行交流 包括熟练度测试，常见QC池，技术重复，盲目的重复项以及包括熟练度测试的计划 最大程度地减少批处理效果和LAB间可变性的方法，我们的团队在该问题中发挥了关键作用 Chear的第一个赠款周期。我们内部协调以最大化效率，并可以灵活地改变我们的优先级 按照CC的指示（即，根据需求需要特定的生物标志物）。我们组织每周转向 委员会（SC）集线器的会议，以协调内置内置内部工作流程，包括收到样品运输， 重新标记，跟踪和进入我们的实验室信息管理系统（LIMS）。我们组织 PI/客户咨询会议，我们在其中审查了设计的父母研究，样品标本 可用性/质量，研究主题暴露方案，健康表型和要求的化学物质类型 要测量的暴露。然后，我们提出最适合PI/客户目标的建议，而 解决在进行测定分析之前可能会限制可行性的任何科学或技术问题。我们 还会跟踪正在进行的工作的进度并为数据中心协调中心生成定期报告 和NIH计划。我们与HEAR数据中心（DC）协调数据报告，以确保我们的 数据库的格式正确，并包含适当的元数据。我们还与DC合作， 客户/pi在解释结果时（即溶血如何影响等离子体中金属的水平， 在尿液中测得的化学物质是候选肥胖症等）和暴露/表型的统计分析 关系。我们组织并实施了一个年度实验室中心研讨会，该研讨会与现有和潜在 暴露测定方法中的客户。我们是唯一在组织此次会议下的实验室中心 Chear以展开理学为主题，并吸引了200名科学参与者。我们使用基于Web的LIMS 通过实验室集线器系统跟踪工作进度的接口，并在实时评估QA/QC 分析。总而言之，我们1）在实验室中心内部协调通信，并在外部与 协调中心，数据中心，PI/客户和NIH计划； 2）制定程序，协议和 系统检查以确保样品流到正确的资源/核心，并遵循QA/QC协议 严格3）保持用户友好的LIM，促进样本跟踪，防止在 样本和结果，并与数据中心的需求集成； 4）提供科学咨询 为PI/客户提供最大化其研究结果信息和质量的服务； 5）确保反馈 客户与资源/内核之间发生沟通，并且此信息是透明的 到CC和NIH，以及6）确保标记实验室集线器计划的透明财政管理。